Results 111 to 120 of about 4,454,225 (289)

Taking stock of existing evidence and closing evidence gaps – Reflections from the National Institute for Health and Care Excellence (NICE) [PDF]

Journal of Health Monitoring, 2020
Kay Nolan
doaj   +1 more source

Liderando mejoras de calidad mediante el desarrollo, implementación, y medición de las guías de buenas prácticas de Enfermería / Leading Quality Improvement through Best Practice Guideline Development, Implementation, and Measurement Science / Liderando com melhor qualidade por meio da elaboração, implementação e avaliação de guias de boas práticas na enfermagem

MedUNAB, 2015
Introducción: La búsqueda de prácticas basadas en la evidencia ha estimulado acciones por parte de un número de grupos a nivel mundial para desarrollar herramientas de conocimiento.
Irmajean Bajnok, RN., MScN., PhD. , Doris Grinspun, RN., MSN., PhD., LLD (Hon)., O.ONT. , Monique Lloyd, RN., PhD. , Heather McConnell, RN., BScN., MA(Ed).   +3 more
doaj  

Guidelines, guidelines, and more guidelines [PDF]

Clinical Cardiology, 2002
openaire   +2 more sources

MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation

FEBS Open Bio, EarlyView.
MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima, Kotone Watanabe, Grigorii Sultanakhmetov, Aoi Fukuchi, Keiya Ito, Sawako Shimizu, Taro Saito, Akiko Asada, Kanae Ando   +8 more
wiley   +1 more source

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

A Guideline for Guidelines: A Novel Method to Assess the Helpfulness of Medical Guidelines

Journal of Clinical Medicine
Background/Objectives: The recommendations included in medical guidelines (GLs) provide important help to medical professionals for making clinical decisions regarding the diagnosis and treatment of various diseases. However, there are no systematic methods to measure the helpfulness of GLs.
Akos Koller, Johanna Takács
openaire   +2 more sources

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

In vitro generation of regulatory T cells: A challenging tool for studying immune aging in humans

FEBS Open Bio, EarlyView.
In vitro induction of human regulatory T cells using standard protocols generates suppressive, Foxp3‐expressing CD4+ T cells independently of TGF‐β supplementation and donor age. Regulatory T (Treg) cells play a key role in immune tolerance and homeostasis.
Lynn Muller, Jana Bleher, Birgit Weinberger, Lourdes Rocamora‐Reverte   +3 more
wiley   +1 more source

Effect of preterm birth on neonatal, infant, child, young adult and adult mortality: a systematic review and meta-analysis

Journal of Perinatal Medicine
Preterm birth is associated with a higher risk of mortality. In 2020, the global incidence of preterm births was reported at 9.9 per 100 live births. This meta-analysis was undertaken to evaluate the effect of preterm birth on mortality among various age
Malshe Nandini Shashikant, Kapoor Anuva, Deshmukh Kalyani P., Goyal Chanchal, Gandhi Aravind P.   +4 more
doaj   +1 more source

Five‐Year Outcomes of Laparoscopic Sphincter‐Preserving Surgery for Rectal Cancer: A Prospective Study in Elderly Vietnamese Patients

Aging and Cancer, EarlyView.
This prospective study demonstrates that laparoscopic sphincter‐preserving surgery is feasible for elderly patients. While overall survival reaches 70% at 5 years, advanced T‐stage and the omission of neoadjuvant therapy significantly drive recurrence, highlighting the need for personalized geriatric protocols despite logistical challenges.
Huu Duc Ho, Quang Le, Ngoc Thach Tran, Van Viet Ung, Loc Vu   +4 more
wiley   +1 more source