Results 121 to 130 of about 1,224 (170)

Exercise and Autonomic Cardiovascular Function—Insights From Spinal Cord‐Injured Humans: A Narrative Review

open access: yesActa Physiologica, Volume 242, Issue 10, October 2026.
ABSTRACT The cardiovascular response to acute exercise is mediated by the autonomic nervous system (ANS) control mechanisms that modulate vascular resistance to support blood pressure and ensure adequate blood flow to active muscles. These autonomic neurocirculatory control mechanisms include a feedforward mechanism, known as central command, and three
Rasmus Kopp Hansen   +5 more
wiley   +1 more source

What if Adam Smith Debated an AI Economist: A Thought Experiment on Markets, Ethics, and the Invisible Hand

open access: yesBusiness Ethics, the Environment &Responsibility, Volume 35, Issue 4, Page 3433-3447, October 2026.
ABSTRACT Can AI‐driven capitalism sustain the moral preconditions of market order? We stage a dialogue between Adam Smith and a steel‐manned “EconAI” to test four Moral‐Market‐Fitness criteria: trustworthiness, fairness, non‐domination, and contestability, across 11 dilemmas.
Alexandra‐Codruța Bîzoi   +1 more
wiley   +1 more source

Dualsteric and dual‐acting modulation of muscarinic receptors by antagonist KH‐5

open access: yesBritish Journal of Pharmacology, Volume 183, Issue 19, Page 5769-5790, October 2026.
Abstract Background and purpose Muscarinic acetylcholine receptors are key therapeutic targets, and ligands engaging both orthosteric and allosteric sites may offer improved selectivity and efficacy. Here, we investigated whether the muscarinic antagonist KH‐5 acts as a dualsteric antagonist and defined its mode of interaction with muscarinic receptors.
Alena Janoušková‐Randáková   +3 more
wiley   +1 more source

Oral Medications for Treating Agitation in a Safety Net Emergency Department.

open access: yesJAMA Netw Open
Cole JB   +6 more
europepmc   +1 more source

Cannabinoid CB1 allosteric ligands suppress inflammatory pain in male mice without tolerance, motor impairment, memory deficits or respiratory depression

open access: yesBritish Journal of Pharmacology, Volume 183, Issue 20, Page 6132-6153, October 2026.
Abstract Background and Purpose Positive allosteric modulators (PAMs) engage sites distinct from the orthosteric CB1 cannabinoid receptor binding site. GAT211, a racemic ligand, contains GAT228 (R) and GAT229 (S) enantiomers. Whether enantiomer‐mediated differences in allosteric activation or positive allosteric modulation translate into differences in
Ifeoluwa D. Solomon   +3 more
wiley   +1 more source

Dissecting the Spectrum of Rare BRAF Mutations in Melanoma: A Nation-Wide Study by the Italian Melanoma Intergroup (IMI). [PDF]

open access: yesPigment Cell Melanoma Res
Dalmasso B   +37 more
europepmc   +1 more source

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