Results 91 to 100 of about 6,042 (221)

Association Between 1‐Year Endoscopic Outcomes and Long‐Term Clinical and Patient‐Relevant Outcomes in Crohn's Disease

JCC Plus, Volume 1, Issue 2, March 2026.
ABSTRACT Background and Aims Achieving endoscopic response (ER), defined as a > 50% reduction from baseline in Simple Endoscopic Score for Crohn's disease (SES‐CD) score, following induction therapy for Crohn's disease (CD) has been linked to improved 1‐year outcomes.
Myrlene Sanon, Shanti Neff‐Baro, Aline Gauthier, Dominik Naessens, Marion L. Vetter, Lewin Eisele, Axel Dignass, Brian Feagan   +7 more
wiley   +1 more source

Comparison of Real-World On-Label Treatment Persistence in Patients with Psoriatic Arthritis Receiving Guselkumab Versus Subcutaneous Tumor Necrosis Factor Inhibitors

Drugs - Real World Outcomes
Background Treatment persistence among patients with psoriatic arthritis (PsA) is essential for achieving optimal treatment outcomes. Guselkumab, a fully human interleukin-23p19-subunit inhibitor, was approved by the United States (US) Food and Drug ...
Jessica A. Walsh, Iris Lin, Ruizhi Zhao, Natalie J. Shiff, Laura Morrison, Bruno Emond, Louise H. Yu, Samuel Schwartzbein, Patrick Lefebvre, Dominic Pilon, Soumya D. Chakravarty, Philip Mease   +11 more
doaj   +1 more source

Reshaping study design for faster extrapolation‐based drug approval in pediatric inflammatory bowel diseases: An ESPGHAN–NASPGHAN position paper

Journal of Pediatric Gastroenterology and Nutrition, Volume 82, Issue 3, Page 867-894, March 2026.
Abstract Children with inflammatory bowel diseases (IBD) have limited access to the available advanced therapies, given the lengthy gap between adult and pediatric approval. We aimed to review key hurdles for pediatric trials and recommend practical solutions.
Dan Turner, Amit Assa, Mikkel Malham, Shira Yuval Bar‐Asher, Carla Rayan, Jeffrey S. Hyams, Holm H. Uhlig, Brad Pasternak, David C. Wilson, Hilary K. Michel, Lissy de Ridder, Eric Zuckerman, Marina Aloi, Peter Szitanyi, Marla C. Dubinsky, Anne M. Griffiths, Roberto Saldana, Javier Martín‐de‐Carpi, Eytan Wine, Richard K. Russell, Jeremy Adler, Joseph Picoraro   +21 more
wiley   +1 more source

The Impact of Methotrexate on Cardiovascular Outcomes in Psoriasis: A Systematic Review and Meta‐Analysis

JEADV Clinical Practice, Volume 5, Issue 1, Page 59-66, March 2026.
This systematic review and meta‐analysis suggest that methotrexate may provide cardiovascular benefits in patients with psoriasis, possibly mediated by the reduction of systemic inflammation, and demonstrates a more favorable cardiovascular safety profile compared with retinoids.
Tiago A. S. Costa, Sheila T. K. Medorima, Renata F. Magalhães   +2 more
wiley   +1 more source

Assessing the Short-Term Efficacy and Safety of Guselkumab for Moderate-to-Severe Plaque Psoriasis: Meta-Analysis of Randomized Controlled Trials

Journal of Immunology Research, 2020
Background. To investigate the efficacy and safety of guselkumab in the treatment of moderate-to-severe plaque psoriasis. Methods. A systematic review was undertaken to identify double-blind randomized controlled trials (RCTs).
Jing Yang, Zongming Wang, Xilin Zhang
doaj   +1 more source

Guselkumab for the treatment of psoriasis - evidence to date [PDF]

, 2019
Psoriasis is a chronic, immune-mediated, inflammatory, and debilitating skin disease with significant impact on patients' quality of life. Its pathogenesis is complex and not yet fully understood. However, the IL-23/IL-17 axis is currently considered the
Nogueira, Miguel, Torres, T.
core   +1 more source

Unravelling the Major Cardiovascular Risks of Systemic Psoriasis Medications: A Literature Systematic Review

JEADV Clinical Practice, Volume 5, Issue 1, Page 32-58, March 2026.
ABSTRACT Background Psoriasis is a chronic inflammatory dermatological condition associated with an elevated risk of cardiovascular events (CVEs). Systemic therapies have transformed disease management, but their cardiovascular (CV) safety profiles remain incompletely understood and inconsistently reported.
Mai Thi Hoai Son, Yves Julien Mbama Biloa, Pauline Gouttefarde, Thomas Franck, Gilles Cizeron, Mathieu Oriol, François Maccari, Elisa Cinotti, Beatrice Trombert‐Paviot, Bienvenu Bongue, Jean‐Luc Perrot   +10 more
wiley   +1 more source

Guselkumab treatment normalizes the stratum corneum ceramide profile and alleviates barrier dysfunction in psoriasis:results of a randomized controlled trial [PDF]

The epidermal inflammation associated with psoriasis drives skin barrier perturbations. The skin barrier is primarily located in stratum corneum (SC). Its function depends on the SC lipid matrix of which ceramides constitute important components. Changes
, Bergmans, Menthe E., Bouwstra, Joke A., Bruijnincx, Lisa J., de Kam, Marieke L., der Kolk, Tessa Niemeyer Van, Klarenbeek, Naomi B., Mergen, Catherine, Rissmann, Robert, Rousel, Jannik, van Doorn, Martijn B.A.   +10 more
core   +3 more sources

Concurrent Psoriasis and Dermatomyositis: Retrospective Analysis and Literature Review

JEADV Clinical Practice, Volume 5, Issue 1, Page 205-210, March 2026.
ABSTRACT Background Psoriasis (PsO) and dermatomyositis (DM) are both autoimmune‐mediated, inflammatory conditions. The concurrence of PsO and DM is rare, and literature on their relationship remains limited. Additionally, cutaneous DM can be challenging to clinically diagnosis, often presenting with psoriasiform clinical features.
Emily R. Gordon, Karishma S. Shah, Sidharth Chand, Bonnie Lee, Janellen Smith, Michelle S. Min   +5 more
wiley   +1 more source

Engagement and retention with remote monitoring in psoriasis: Findings from the mySkin study

Journal of the European Academy of Dermatology and Venereology, Volume 40, Issue 4, Page e274-e277, April 2026.
Weiyu Ye, Niamh Dooley, Wei Ren Tan, Bolaji Coker, Teresa Tsakok, Lucy Moorhead, Jade Pizzato, Kingsley Powell, Madeline Kroah‐Hartman, Alexandra Paolino, Treasa Jiang, Freya Jackson‐Duffy, John Y. W. Lee, Manpreet K. Sagoo, Georgia Sewell, Camille Lancelot, Helen McAteer, John Weinman, Jonathan N. Barker, Sarah Chapman, Sam Norton, Catherine H. Smith, Satveer K. Mahil   +22 more
wiley   +1 more source