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Diversity and complexity in neural organoids
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Naturwissenschaftliches Verständnis entsteht immer dann, wenn ein naturwissenschaftliches Konzept mit einem Phänomen der Natur kognitiv verknüpft wird.
Christoph Gut
doaj +1 more source
The human gut microbiome across the life course
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero +4 more
wiley +1 more source
THE PLACE AND ROLE OF THE MANAGING AUTHORITY FOR OPERATIONAL PROGRAM FOR FISHERIES AND MARITIME AFFAIRS (AM-POPAM) IN THE ABSORPTION OF EUROPEAN FUNDS FOR THE PERIOD 2014-2020 [PDF]
This article analyzes the activity carried out by the Managing Authority for Operational Program for Fisheries and Maritime Affairs (POPAM) within the Directorate General of Fisheries (AM-POPAM) in order to ensure the information and implementation ...
Sebastian GUT
doaj
Impact of Gut Microbiome on Gut Permeability in Liver and Gut Diseases
Hepatobiliary and gastrointestinal conditions, including chronic liver diseases and inflammatory bowel disease, are associated with significant morbidity and mortality globally. While the pathophysiology and symptoms vary from one disease to another, aberrations of the gut microbiome with deleterious microbial products affecting the intestinal barrier ...
Punnag Saha, Phillipp Hartmann
openaire +3 more sources
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
Objectives Alzheimer’s disease and related dementias (AD/ADRDs) are rising global public health challenges, disproportionately affecting ageing populations. Although higher prevalence estimates have been reported in high-income countries (HICs), the most
Zhahirul Islam +11 more
doaj +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Why is epidermal growth factor present in the gut lumen? [PDF]
Wright, NA, Playford, RJ
core +4 more sources

