Results 61 to 70 of about 1,799,345 (302)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Scientific ReportsShigellosis remains a common gastrointestinal disease mostly in children
Asaduzzaman Asad +8 more
doaj +1 more source
GUTs and Exceptional Branes in F-theory - II: Experimental Predictions [PDF]
, 2009 We consider realizations of GUT models in F-theory. Adopting a bottom up approach, the assumption that the dynamics of the GUT model can in principle decouple from Planck scale physics leads to a surprisingly predictive framework.
Beasley, Chris +2 more
core +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
TGFβ/BMP immune signaling affects abundance and function of C. elegans gut commensals. [PDF]
, 2019 The gut microbiota contributes to host health and fitness, and imbalances in its composition are associated with pathology. However, what shapes microbiota composition is not clear, in particular the role of genetic factors.
Berg, Maureen +5 more
core +2 more sources
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Shift Work: Gut Health and Metabolic Disease [PDF]
, 2020 The number of people engaged in shift work continues to rise, and with it the research linking shift work to various diseases and conditions. Shift work changes the body’s sleeping patterns and circadian rhythms which has an effect on all parts of the ...
Lane, Hailey
core +1 more source
Laboratory investigation of daily food intake and gut evacuation in larvae of African catfish Clarias gariepinus under different feeding conditions [PDF]
, 2010 Temporary accumulation of ascorbic acid 2-sulfate (AAS) was measured to estimate food intake and gut evacuation in larvae of African catfish. Fish larvae were fed decapsulated cysts of Artemia containing AAS.
García-Ortega, A. +5 more
core +3 more sources
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Scientific ReportsThe accurate preclinical prediction of adverse drug reactions (ADRs), such as nausea and vomiting, remains a challenge. The Gastro-Intestinal Pacemaker Activity Drug Database (GIPADD) ( http://www.gutrhythm.com/public_database ) is a new source of ...
Hephaes Chuen Chau +2 more
doaj +1 more source