Results 71 to 80 of about 979,913 (296)

Through ageing, and beyond: gut microbiota and inflammatory status in seniors and centenarians [PDF]

, 2010
BACKGROUND: Age-related physiological changes in the gastrointestinal tract, as well as modifications in lifestyle, nutritional behaviour, and functionality of the host immune system, inevitably affect the gut microbiota, resulting in a greater ...
Nylund Lotta, Ostan, Rita, Janne Nikkïla, Elisa Pini, Elena Biagi, Rita Ostan, Daniela Monti, Pini Elisa, Satokari, Reetta, Satokari, R.M., Candela, Marco, Nylund L., Nikkilä, Janne Tapio, Nylund, Lotta, Candela Marco, Franceschi Claudio, Willem De Vos, De Vos Willem, Brigidi, Patrizia, Nikkila J., Franceschi, C., Monti, Daniela, Marco Candela, Reetta Satokari, Bucci Laura, Vos, W.M., de, Candela, M., Pini, E., Monti, D., Pini, Elisa, Nikkïla, J., Bucci, Laura, Satokari R., Lotta Nylund, Nikkïla Janne, Satokari Reetta, Monti D., Franceschi, Claudio, Patrizia Brigidi, De Vos W., Biagi, E., Monti Daniela, Biagi Elena, Ostan Rita, Ostan, R., De Vos, Willem, Bucci, L., Laura Bucci, Brigidi, P., Nylund, L., Claudio Franceschi, Brigidi Patrizia, Biagi, Elena   +52 more
core   +2 more sources

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

An application of deep learning model InceptionTime to predict nausea, vomiting, diarrhoea, and constipation using the gastro-intestinal pacemaker activity drug database (GIPADD)

Scientific Reports
The accurate preclinical prediction of adverse drug reactions (ADRs), such as nausea and vomiting, remains a challenge. The Gastro-Intestinal Pacemaker Activity Drug Database (GIPADD) ( http://www.gutrhythm.com/public_database ) is a new source of ...
Hephaes Chuen Chau, Julia Yuen Hang Liu, John Anthony Rudd   +2 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Trastornos de la interacción cerebro-intestino (trastornos funcionales digestivos): neuromoduladores en la práctica clínica (parte I)

Revista Colombiana de Gastroenterología
Introducción: en este artículo de revisión se desarrollan los principios básicos para el uso y los mecanismos de acción de los neuromoduladores utilizados en la práctica clínica y su papel en el tratamiento de los diferentes trastornos de la interacción
Luis Fernando Pineda Ovalle, David Benigno Páramo Hernández, Laura Marcela Moya Valenzuela, Alejandro Concha Mejía, Juan David Páramo Díaz   +4 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Why is epidermal growth factor present in the gut lumen? [PDF]

, 1996
Wright, NA, Playford, RJ
core   +4 more sources

Ustawowe podstawy działania archiwów niemieckich. Federalne i krajowe ustawy archiwalne

Archeion, 2020
Statutory grounds for the activity of German archives. Federal and national laws on archives Laws on archives lay down the purposes and tasks of archives.
Gut, Paweł
doaj   +1 more source

The Gut Microbiota Contributes to Systemic Responses and Liver Injury in Gut-Derived Sepsis

, 2023
The gut microbiota, as a major source of opportunistic pathogens, poses a great threat to systemic infection, whereas the role of the gut microbiota in sepsis is underestimated.
Jiajia Ma, Huiru Liu, Ying Luo, Fengmei Wang, Peng Zhang, Huiting Deng, Dandan Wang, Meiqi Zhao   +7 more
core   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source