Results 51 to 60 of about 942,965 (287)

Multidrug-resistant conjugative plasmid carrying mphA confers increased antimicrobial resistance in Shigella

Scientific Reports
Shigellosis remains a common gastrointestinal disease mostly in children 
Asaduzzaman Asad, Israt Jahan, Moriam Akter Munni, Ruma Begum, Morium Akter Mukta, Kazi Saif, Shah Nayeem Faruque, Shoma Hayat, Zhahirul Islam   +8 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Trastornos de la interacción cerebro-intestino (trastornos funcionales digestivos): neuromoduladores en la práctica clínica (parte II)

Revista Colombiana de Gastroenterología
Introducción: este artículo continúa la revisión de los neuromoduladores utilizados en la práctica clínica y su papel en el tratamiento de los diferentes trastornos de la interacción cerebro-intestino (TICI), en particular los gástricos, intestinales y ...
David Benigno Páramo Hernández, Luis Fernando Pineda Ovalle, Laura Marcela Moya Valenzuela, Alejandro Concha Mejía, Juan David Páramo Díaz   +4 more
doaj   +1 more source

Ustawowe podstawy działania archiwów niemieckich. Federalne i krajowe ustawy archiwalne

Archeion, 2020
Statutory grounds for the activity of German archives. Federal and national laws on archives Laws on archives lay down the purposes and tasks of archives.
Gut, Paweł
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Challenges in Diagnosis and Management of Crohn's Disease in Bangladesh With Long Term Follow‐Up

Clinical Case Reports
Crohn's disease (CD) is a chronic autoimmune inflammatory bowel disease (IBD) with significant diagnostic and therapeutic challenges. We reported a case of a 20‐year‐old Bangladeshi male with an 8‐month history of severe upper abdominal pain, bowel ...
Imtiaz Abdullah, Imran Hasan, Mantaka Rahman, Shoma Hayat, Nowshin Papri, Nusrat Fatema, Ahmedul Kabir, Zhahirul Islam   +7 more
doaj   +1 more source

Liver metastases in gastroenteropancreatic neuroendocrine tumours – treatment methods

Gastroenterology Review, 2020
Surgical approaches that allow the safe treatment of multiple, bilateral, large tumours, and that combine extirpative, ablative and interventional therapies, have expanded the population of patients with neuroendocrine tumors (NET) liver metastases (LMs)
Paweł Gut
doaj   +1 more source

Comparison of microbial signatures between paired faecal and rectal biopsy samples from healthy volunteers using next-generation sequencing and culturomics

Microbiome, 2022
Background Faecal samples are frequently used to characterise the gut microbiota in health and disease, yet there is considerable debate about how representative faecal bacterial profiles are of the overall gut community.
Indrani Mukhopadhya, Jennifer C. Martin, Sophie Shaw, Aileen J. McKinley, Silvia W. Gratz, Karen P. Scott   +5 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

An application of deep learning model InceptionTime to predict nausea, vomiting, diarrhoea, and constipation using the gastro-intestinal pacemaker activity drug database (GIPADD)

Scientific Reports
The accurate preclinical prediction of adverse drug reactions (ADRs), such as nausea and vomiting, remains a challenge. The Gastro-Intestinal Pacemaker Activity Drug Database (GIPADD) ( http://www.gutrhythm.com/public_database ) is a new source of ...
Hephaes Chuen Chau, Julia Yuen Hang Liu, John Anthony Rudd   +2 more
doaj   +1 more source