Results 81 to 90 of about 942,965 (287)

Through ageing, and beyond: gut microbiota and inflammatory status in seniors and centenarians [PDF]

, 2010
BACKGROUND: Age-related physiological changes in the gastrointestinal tract, as well as modifications in lifestyle, nutritional behaviour, and functionality of the host immune system, inevitably affect the gut microbiota, resulting in a greater ...
Nylund Lotta, Ostan, Rita, Janne Nikkïla, Elisa Pini, Elena Biagi, Rita Ostan, Daniela Monti, Pini Elisa, Satokari, Reetta, Satokari, R.M., Candela, Marco, Nylund L., Nikkilä, Janne Tapio, Nylund, Lotta, de Vos, W.M., Candela Marco, Franceschi Claudio, Willem De Vos, De Vos Willem, Brigidi, Patrizia, Nikkila J., Franceschi, C., Monti, Daniela, Marco Candela, Reetta Satokari, Bucci Laura, Vos, W.M., de, Candela, M., Pini, E., Monti, D., Pini, Elisa, Nikkïla, J., Bucci, Laura, Satokari R., Lotta Nylund, Nikkïla Janne, Satokari Reetta, Monti D., Franceschi, Claudio, Patrizia Brigidi, De Vos W., Biagi, E., Monti Daniela, Biagi Elena, Ostan Rita, Ostan, R., De Vos, Willem, Bucci, L., Laura Bucci, Brigidi, P., Nylund, L., Claudio Franceschi, Brigidi Patrizia, Biagi, Elena   +53 more
core   +2 more sources

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Apprendre. Oui, mais comment ?

Mosaïque, 2011
Apprendre. Oui, mais comment ? Cette question posée par Philippe Meirieu (1991) au début des années quatre-vingt reste toujours d’actualité. Dans la présente communication je m’attache à examiner la notion d’apprendre.
Dagmara Gut
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Study of a Broadband Difference Interferometer Based on Low-Cost Polymer Slab Waveguides

Nanomaterials, 2019
A model and the waveguide parameters of a broadband, polymer-based slab waveguide difference interferometer is presented in this paper. The parameters were determined based on knowledge of the dispersion in the structure materials used to fabricate the ...
Kazimierz Gut
doaj   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Preterm gut microbiota and metabolome following discharge from intensive care [PDF]

, 2015
The development of the preterm gut microbiome is important for immediate and longer-term health following birth. We aimed to determine if modifications to the preterm gut on the neonatal intensive care unit (NICU) impacted the gut microbiota and ...
Skeath, Tom, Perry, J. D. (John), Nelson, Andrew, Stewart, Christopher, Marrs, Emma, Embleton, Nicholas, Fernstad, Sara J., Fernstad, Sara Johansson, Berrington, Janet, Marrs, E. C. L. (Emma), Cummings, Stephen, Perry, John, Skeath, Thomas   +12 more
core   +1 more source

Blue poo : Impact of gut transit time on the gut microbiome using a novel marker

, 2021
Background and aims: Gut transit time is a key modulator of host-microbiome interactions, yet this is often overlooked, partly because reliable methods are typically expensive or burdensome.
Leeming, Emily R.,, Bakker, Elco, Wolf, Jonathan, Francis, Lucy, Franks, Paul,, Valdes, Ana M.,, Dimidi, Eirini,, Leeming, Emily R., Asnicar, Francesco, Berry, Sarah E., Mazidi, Mohsen, Segata, Nicola, Valdes, Ana M., Wolf, Jonathan,, Mazidi, Mohsen,, Gibson, Rachel,, Al Khatib, Haya,, Dimidi, Eirini, Davies, Richard, Spector, Timothy D., Francis, Lucy,, Segata, Nicola,, Davies, Richard,, Gibson, Rachel, Bakker, Elco,, Chan, Andrew,, Spector, Timothy D.,, Hadjigeorgiou, George, Berry, Sarah E.,, Franks, Paul, Hadjigeorgiou, George,, Chan, Andrew, Al Khatib, Haya, Asnicar, Francesco,, Lund University.   +34 more
core   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Gut Microbiota as Potential Orchestrators of Irritable Bowel Syndrome

, 2015
Irritable bowel syndrome (IBS) is a multifactorial functional disorder with no clearly defined etiology or pathophysiology. Modern culture-independent techniques have improved the understanding of the gut microbiota's composition and demonstrated that an
Bennet, Sean,, Simrén, Magnus,, Öhman, Lena,   +2 more
core   +1 more source