Results 121 to 130 of about 56,089 (298)

Integrating Aggregate Materials and Machine Learning Algorithms: Advancing Detection of Pathogen‐Derived Extracellular Vesicles

open access: yesAggregate, EarlyView.
Pathogen‐derived extracellular vesicle detection: theoretical insights and advanced methodologies: This review explores the theoretical foundations and practical applications of pEV detection, emphasizing the challenges and innovative strategies involving novel aggregate materials and machine learning for enhanced diagnostic accuracy.
Lihan Lai   +6 more
wiley   +1 more source

Plateau hypoxia attenuates the metabolic activity of intestinal flora to enhance the bioavailability of nifedipine

open access: yesDrug Delivery, 2018
Nifedipine is completely absorbed by the gastrointestinal tract and its pharmacokinetics and metabolism may be influenced by microorganisms. If gut microbes are involved in the metabolism of nifedipine, plateau hypoxia may regulate the bioavailability ...
Juanhong Zhang   +5 more
doaj   +1 more source

Quantitative Analysis of Saliency Models [PDF]

open access: yesarXiv, 2016
Previous saliency detection research required the reader to evaluate performance qualitatively, based on renderings of saliency maps on a few shapes. This qualitative approach meant it was unclear which saliency models were better, or how well they compared to human perception. This paper provides a quantitative evaluation framework that addresses this
arxiv  

An argument for using anaerobes as microbial cell factories to advance synthetic biology and biomanufacturing

open access: yesAIChE Journal, EarlyView.
Abstract Anaerobes thrive in the absence of oxygen and are an untapped reservoir of biotechnological potential. Therefore, bioprospecting efforts focused on anaerobic microbial diversity could rapidly uncover new enzymes, pathways, and chassis organisms to drive biotechnology innovation.
Thomas S. Lankiewicz   +3 more
wiley   +1 more source

Antifungal Compounds from the Leaves of Rhynchosia minima

open access: yesChemistry &Biodiversity, Volume 19, Issue 12, December 2022., 2022
Abstract Rhynchosia minima, commonly known as jumby bean, is used as a remedy for respiratory ailments in various parts of the world. It is also used by South African traditional healers to treat heart or chest pain. This study aimed to investigate the bioactive constituents of the leaf extracts of R.
Adetola H. Adewole   +4 more
wiley   +1 more source

Gastrointestinal microbiota contributes to the development of murine transfusion-related acute lung injury

open access: yesBlood Advances, 2018
: Transfusion-related acute lung injury (TRALI) is a syndrome of respiratory distress upon blood transfusion and is the leading cause of transfusion-related fatalities.
Rick Kapur   +12 more
doaj  

Abnormal metabolism of gut microbiota reveals the possible molecular mechanism of nephropathy induced by hyperuricemia

open access: yesActa Pharmaceutica Sinica B, 2020
The progression of hyperuricemia disease is often accompanied by damage to renal function. However, there are few studies on hyperuricemia nephropathy, especially its association with intestinal flora.
Libin Pan   +11 more
doaj  

Brassinin from Brassica campestris L. inhibits colorectal cancer by inducing p62/NRF2/GPX4‐regulated ferroptosis

open access: yesAnimal Models and Experimental Medicine, EarlyView.
BSN suppresses the cell viability of colorectal cancer by inducing GPX4‐regulated ferroptosis. BSN may bind to NRF2 protein to inactivate the NRF2 signaling, inhibiting the expression of p62 and HO‐1. Abstract Background Indole phytoalexins, plant‐derived compounds present in cruciferous vegetables, have demonstrated anticancer properties.
Shi‐Yuan Wen   +5 more
wiley   +1 more source

Pharmacokinetic analysis on compatibility of Atractylodes macrocephala and Paeoniae radix herb pair ameliorates functional constipation model rats using microdialysis with ultra‐performance liquid chromatography

open access: yesAnimal Models and Experimental Medicine, EarlyView.
The active ingredient of the drug determines the effect of the drug, and the compatibility affects the content of the active ingredient of the drug, which in turn affects the exertion of the efficacy. This study partly clarifies the rationality and compatibility of AM‐PR in the treatment of FC.
Xiaoting Wang   +4 more
wiley   +1 more source

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