Results 131 to 140 of about 1,048,386 (358)
Pharmacological ResearchThe gut microbiota, known as the “forgotten organ” and “human second genome,” comprises a complex microecosystem. It significantly influences the development of various tumors, including colorectal, liver, stomach, breast, and lung cancers, through both ...
Xuejiao Wei +8 more
doaj +1 more source
Linchuang shenzangbing zazhi, 2021 The incidence of chronic kidney disease（CKD）in China has remained elevated and it shows an annually rising trend.However,no radical cure is not currently available.Exploring the risk factors of CKD is a research focus of nephrology.It is generally ...
Chen Li-hua +3 more
doaj
Composition and immuno-stimulatory properties of extracellular DNA from mouse gut flora
World Journal of Gastroenterology, 2017 AIM To demonstrate that specific bacteria might release bacterial extracellular DNA (eDNA) to exert immunomodulatory functions in the mouse small intestine.
Ce Qi +8 more
semanticscholar +1 more source
Advanced Science, EarlyView.Wound infections induce gcFGF8a expression, which subsequently executes direct antimicrobial activity to suppress local infection while simultaneously activating the FGFR4‐mediated ERK/AKT‐mTOR signaling cascade, thereby upregulating HIF1α and enhancing glycolysis. These coordinated actions synergistically promote tissue repair by eliminating pathogens
Ya‐Zhen Hu +6 more
wiley +1 more source
Role of the microbiome, probiotics, and 'dysbiosis therapy' in critical illness. [PDF]
, 2016 Purpose of reviewLoss of 'health-promoting' microbes and overgrowth of pathogenic bacteria (dysbiosis) in ICU is believed to contribute to nosocomial infections, sepsis, and organ failure (multiple organ dysfunction syndrome).
Knight, Rob +2 more
core +2 more sources
Research Progress on Biomaterials with Immunomodulatory Effects in Bone Regeneration
Advanced Science, EarlyView.This review highlights recent advanced in immunomodulatory biomaterials for bone repair, focusing on design strategies, immune interactions, and clinical potential. Abstract The immune system plays a pivotal role in bone regeneration, and biomaterials engineered to modulate immune responses present a promising strategy for the treatment of extensive ...
Jianan Li +11 more
wiley +1 more source
The gut–eye axis: from brain neurodegenerative diseases to age-related macular degeneration
Neural Regeneration ResearchAge-related macular degeneration is a serious neurodegenerative disease of the retina that significantly impacts vision. Unfortunately, the specific pathogenesis remains unclear, and effective early treatment options are consequently lacking.
Qianzi Jin +4 more
doaj +1 more source
Advanced Science, EarlyView.During the progression of CRC, MDM2, as an E3 ubiquitin ligase, promotes the degradation of the LLGL2 protein. Reduced expression of the LLGL2 protein leads to the loss of support for the CNOT1 protein, decreasing the degradation of THBS3 mRNA. The increased THBS3 further activates the PI3K‐Akt pathway, promoting the proliferation and metastasis of CRC.
Jiayan Huang +8 more
wiley +1 more source
Changes in the intestinal microbiota after a short period of dietary over-indulgence, representative of a holiday or festival season [PDF]
, 2008 The effects on the intestinal microbiota of a short period of marginal over-eating, characteristic of holiday or festival periods, were investigated in a pilot study.
Gougoulias, Christos +5 more
core
Role of Cytolethal Distending Toxin in Altered Stool Form and Bowel Phenotypes in a Rat Model of Post-infectious Irritable Bowel Syndrome. [PDF]
, 2012 Background/aimsCampylobacter jejuni infection is a leading cause of acute gastroenteritis, which is a trigger for post-infectious irritable bowel syndrome (PI-IBS). Cytolethal distending toxin (CDT) is expressed by enteric pathogens that cause PI-IBS. We
Alpern, Joel +12 more
core +1 more source