Results 131 to 140 of about 156,706 (322)

Folic Acid‐Modified Ginger‐Derived Exosome‐Like Nanoparticles Co‐Delivering Sunitinib Suppress Renal Cell Carcinoma via PI3K‐Akt Pathway Inhibition, P‐gp Downregulation, and Macrophage Reprogramming

Advanced Science, EarlyView.
FPD‐GELNs co‐deliver Su and bioactive components. This active‐passive dual‐targeting strategy suppresses the progression of RCC through the following mechanisms: 1) inhibition of the PI3K‐Akt signaling pathway; 2) downregulation of ABCB1/P‐gp to enhance the chemosensitivity of RCC to Su; and 3) reprogramming of macrophages toward M1 polarization and ...
Haoyu Xu, Daixing Hu, Shixue Liu, Lei Yang, Junwu Li, Yuanyuan Bai, Guozhi Zhao, Wei Tang, Li Jiang   +8 more
wiley   +1 more source

Bacterial Communities in Central European Bumblebees: Low Diversity and High Specificity [PDF]

, 2018
Recent studies on the microbial flora of the honeybee gut have revealed an apparently highly specific community of resident bacteria that might play a role in immune defence and food preservation for their hosts. However, at present, very little is known
Koch, Hauke, Schmid-Hempel, Paul
core  

Biodegradable Adhesive Systems for Bio‐Integrated Applications

Advanced Science, EarlyView.
Biodegradable adhesives provide temporary yet reliable adhesion while degrading into safe, non‐toxic by‐products under physiological or environmental conditions. This review summarizes recent developments in physical and chemical adhesion mechanisms—including hydrogen bonding, catechol chemistry, amine‐carboxyl coupling, and emerging diazirine and urea
Won Bae Han, Sungkeun Han, Prashant Shivaji Shewale, Hyewon Cho, Li‐Hyun Kim, Venkata Ramesh Naganaboina, Suk‐Won Hwang   +6 more
wiley   +1 more source

With the great complexity unveiling, can we still decipher the interaction between gut flora and the host in inflammatory bowel disease to find out the mechanism and cause? How? [PDF]

, 2008
Xiaofa Qin
openalex   +1 more source

Trigonelline Improves Metabolism and Cardiac Function of HFpEF Mice Via Gut Microbiome Alterations‐Mediated AMPK Activation

Advanced Science, EarlyView.
Metabolomics analyses reveal that trigonelline is markedly reduced in HFpEF hearts. Trigonelline supplementation alleviates metabolic disorders and improves cardiac function in HFpEF mice via gut microbiota‐mediated AMPK activation. Abstract Heart failure with preserved ejection fraction (HFpEF) is a prevalent end‐manifestation of cardiovascular ...
Zhe Cheng, Xiaowen Wang, Jiang Yu, Xiaorong Li, Qing Tang, Can Qu, Ding Yang, Yuanjing Li, Yong Xia, Yongzheng Guo   +9 more
wiley   +1 more source

Microbial profile and putative microbial origin of anorectal abscess based on 16S rDNA sequencing

Frontiers in Cellular and Infection Microbiology
BackgroundAnorectal abscess is a common bacterial infectious disease; however, its pathogenesis remains unclear. Although there is emerging evidence linking gut microbiota to anorectal abscesses, knowledge of the microbial origin of this disease remains ...
Shanzhong Chen, Shanzhong Chen, Chun Dai, Hongyuan Zhao, Yifan Gu, Kuijun Sun, Xingran Yao, Feng Jiang, Feng Jiang, Renjie Shi, Renjie Shi   +10 more
doaj   +1 more source

Gut-flora metabolites is not associated with synchronous carotid artery plaque and non-alcoholic fatty liver disease in asymptomatic adults

, 2021
Ying‐Chun Lin, Horng‐Yuan Wang, Yang‐Che Kuo, Ming‐Jen Chen, Ming‐Shiang Wu, Chun‐Jen Liu, Horng‐Woei Yang, Shou‐Chuan Shih, Lo‐Yip Yu, Hung-Ju Ko, Hung‐I Yeh, Kuang‐Chun Hu   +11 more
openalex   +1 more source

Effects of Clostridium difficile on the human immune response [PDF]

, 2013
Clostridium difficile is a bacterium that is rapidly becoming a large issue in the medical community due to its tendency to infect hospital patients and its resistance to antibiotics.
McGovern, Mike
core   +1 more source

Nanomedicines Against Mitochondrial Dysfunction‐Induced Metabolic Diseases

Advanced Science, EarlyView.
Mitochondrial dysfunction is central to metabolic diseases. Nanomedicine offers transformative approaches for restoring function via targeted delivery, responsive release, and multimodal therapy. This review outlines the pathological basis, nanocarrier design, organelle‐specific targeting, recent advances, and future clinical translation challenges ...
Ke Xu, Leyi Wang, Tao Lv, Chen Jin, Qiong Wu, Yongjie Zhou, Gang Xu, Zhenyu Duan, Kui Luo, Jiayin Yang   +9 more
wiley   +1 more source

Intestinal Metabolism of Crocin and a Pharmacokinetics and Pharmacodynamics Study in the Chronic Social Defeat Stress Mouse Model

Pharmaceuticals
Orally administered crocin rapidly and efficiently rescues depressive-like behaviors in depression models; however, crocin levels in the circulatory and central nervous systems are rather low.
Fan Xiao, Yulong Song, Guangji Wang, Jiye Aa   +3 more
doaj   +1 more source