Results 321 to 330 of about 1,063,331 (361)

Cobalamin‐Dependent Aryl Methyl Ether O‐Demethylases: Promising Enzymes for Biocatalytic Applications from Lignin Valorization to Organic Synthesis

ChemCatChem, EarlyView.
Cobalamin‐dependent aryl methyl ether O‐demethylases have high potential for biocatalytic applications, including lignin valorization and synthetic chemistry. In this review, we provide a detailed overview of such O‐demethylase systems identified to date from various microorganisms, including their mechanism, substrate scope and selectivity, and ...
Niels Krabbe Johnsen, Santipap Chaiyasarn, Zheng Guo, Jaehong Han, Bekir Engin Eser   +4 more
wiley   +1 more source

The Aging Gut–Brain Axis: Effects of Dietary Polyphenols and Metal Exposure

Chronic Diseases and Translational Medicine, EarlyView.
The influence of gut microbiota on brain health ABSTRACT Diet provides essential metals, which are required for the growth, development, and well‐functioning of the body. Nonetheless, some natural and human activities add toxic heavy metals to the diet, consequently introducing them to our bodies, resulting in several disorders and death. The intestine,
Luqi Cao, Saurabh Kumar Jha, Neha Gupta, Xiang Chen, Renuka Soni, Luoxi Yuan, Rashi Srivastava, Zhe‐Sheng Chen   +7 more
wiley   +1 more source

Dietary Berberine Reduced Oxido‐Inflammatory Stress in Rats' Livers and Kidneys, Supplemented from Prepuberty to Adulthood

ChemFoodChem, EarlyView.
Berberine (BER) demonstrates significant protective effects on the hepatorenal system in rats, mediated through various cellular and molecular mechanisms spanning from the prepubertal stage through adulthood. These mechanisms encompass antioxidant, anti‐inflammatory, and anti‐apoptotic activities, in addition to modulation of essential signalling ...
Solomon Owumi, Bayode Oluwawibe, Harieme Agbarogi, Moses T. Otunla, Uche Arunsi, Jesutosin O. Babalola, Chioma Irozuru, Chima Amadi, Ahmad Altayyar   +8 more
wiley   +1 more source

Total Synthesis and Analysis of Phenolic Phytoprostanes, Oxidized Derivatives of Lipophenols

Chemistry – A European Journal, EarlyView.
The total synthesis of four hydroxytyrosol‐phytoprostanes (PhytoPs‐HT) was achieved in 20 steps, enabling their first identification as HT‐α‐linolenate oxidation products. This work revealed new oxidized derivatives of lipophenols via UHPLC‐MS/MS analysis, offering a strategy to trace HT‐derived compounds in complex matrices, aiding food and biomedical
M. Jordan Lehoux, Ángel Sánchez‐Illana, Pablo Miralles, Valérie Bultel‐Poncé, Thierry Durand, Céline Crauste, Camille Oger   +6 more
wiley   +1 more source

Conserved Phosphorylation of the Myosin1e TH1 Domain Impacts Membrane Association and Function in Yeast and Worms

Cytoskeleton, EarlyView.
ABSTRACT Cells have an intrinsic ability to rapidly respond to environmental change to regulate cell cycle progression and membrane organisation, thereby affecting cell growth and division. The actin cytoskeleton is a highly dynamic complex of proteins that can rapidly reorganise to change the growth pattern of a cell.
Holly R. Brooker, Karen Baker, Marina Ezcurra, Philippe P. Laissue, Lin Wang, Michael A. Geeves, Jennifer M. Tullet, Daniel P. Mulvihill   +7 more
wiley   +1 more source

Molecular Docking and Target‐Specific Binding Profiles of Benzosuberane‐Based Compounds

ChemMedChem, EarlyView.
Benzosuberane represents a promising scaffold in medicinal chemistry. Several benzosuberane‐based derivatives are described in this review as anticancer agents, including antivascular agents, DNA‐intercalators, receptor modulators and kinase inhibitors.
Michail A. Saragatsis, Gemma K. Kinsella, James F. Curtin, Tao Zhang   +3 more
wiley   +1 more source

Pharmacomicrobiomics

Clinical Pharmacology &Therapeutics, EarlyView.
Oral medications encounter gut commensal microbes that participate directly and indirectly in drug effects through metabolism, interactions with drug metabolites, or production of substrates that compete with drugs for drug‐metabolizing enzymes, consequently influencing drug pharmacokinetics.
Naomi Gronich, Naama Geva‐Zatorsky, Rachel Herren, Libusha Kelly, Ziv Cohen, Haiying Zhou, Yi‐Ching Chen, Khalid Shah, Talin A. Robinson‐Catala, Grecia Frisby, Jason H. Karnes, Lisl Shoda   +11 more
wiley   +1 more source

Late Pleistocene to Holocene sedimentation in the Great Blue Hole (Lighthouse Reef, Belize): Results from a 30 m long core

The Depositional Record, EarlyView.
A 30 m long sedimentary succession at the bottom of the Belize Blue Hole represents terrestrial cenote (12.5–7.2 ka BP), restricted marine swamp (7.2–5.7 ka BP) and fully marine lagoonal phases (5.7–0 ka BP) on Lighthouse Reef carbonate platform. Post‐glacial and Holocene sea‐level rise largely controlled the sedimentological, faunal and floral changes
Eberhard Gischler, Dominik Schmitt, Annika Wiegand, Hermann Behling, Lyudmila Shumilovskikh, Martin Melles, Volker Wennrich, Elija Nolte, Jozef Grego, Flavio S. Anselmetti, Hendrik Vogel, Daniel Birgel, Jörn Peckmann   +12 more
wiley   +1 more source

The Cenomanian–Turonian boundary interval in the Western Canada Foreland Basin: Stratigraphy, geochemistry, geochronology and sea‐level changes recorded in expanded and condensed clastic successions

The Depositional Record, EarlyView.
Shallow‐marine mudstone of the Cretaceous Kaskapau Formation in the British Columbia foredeep preserves a 185 m thick record of OAE2. The organic carbon‐isotope and osmium‐isotope excursions can be correlated in detail with other Cenomanian–Turonian boundary sections around the world.
A. Guy Plint, Darren R. Gröcke, David Selby, Ireneusz Walaszczyk, Sandra L. Kamo, Ian Jarvis, João Trabucho‐Alexandre, Jessica Flynn, Frederick J. Longstaffe, Kienan P. Marion, Bogdan L. Varban, Alice D. C. Du Vivier, David Uličný   +12 more
wiley   +1 more source

Barsak florasının (Gut flora –Gut mikrobiyota) özellikleri, vajinal ve sezaryen doğum ile ilişkisi

, 2017
Hikmet Hassa
openalex   +1 more source