Results 151 to 160 of about 746,471 (377)

The gut microbiome: Relationships with disease and opportunities for therapy. [PDF]

open access: yes, 2019
Over the past decade, our view of human-associated microbes has expanded beyond that of a few species toward an appreciation of the diverse and niche-specialized microbial communities that develop in the human host with chronological age.
Durack, Juliana, Lynch, Susan V
core  

Influence of diet on the gut microbiome and implications for human health

open access: yesJournal of Translational Medicine, 2017
Recent studies have suggested that the intestinal microbiome plays an important role in modulating risk of several chronic diseases, including inflammatory bowel disease, obesity, type 2 diabetes, cardiovascular disease, and cancer.
Rasnik K. Singh   +11 more
semanticscholar   +1 more source

Multitasking Smart Intestinal Capsule Robot: A Cutting‐Edge Platform for Sampling, Diagnosis, and Therapy

open access: yesAdvanced Robotics Research, EarlyView.
Gut microbiota and biomarkers are linked to diseases like neurological disorders and metabolic syndromes. Ingestible capsule robots enable minimally invasive gut health assessment. This article proposes a promising direction for the advancement of capsule robots, integrating in situ sampling, real‐time diagnostics, and personalized therapy.
Xizong Chen   +3 more
wiley   +1 more source

The Brain-Gut-Microbiome Axis Across the Life Continuum and the Role of Microbes in Maintaining the Balance of Health

open access: yesJournal of Integrative Neuroscience
There is a growing body of evidence that the interaction between various microbial organisms and the human host can affect various physical and even mental health conditions.
Tyler Halverson   +1 more
doaj   +1 more source

Dual‐Functional Ingestible Passive Capsules for High‐Throughput Intestinal Sampling with Sealed Containment and Targeted Drug Delivery

open access: yesAdvanced Robotics Research, EarlyView.
To address challenges in high‐throughput intestinal sampling with sealed containment and target drug delivery, we developed a dual‐functional ingestible passive capsule with a dual‐triggered control system based on pH‐response and mechanical actuation.
Libing Huang   +9 more
wiley   +1 more source

Multiomics Analyses Reveal an Essential Role of Tryptophan in Treatment of csDMARDs in Rheumatoid Arthritis

open access: yesAdvanced Science, EarlyView.
Rheumatoid arthritis is a disease characterized by joint inflammation. Approximately 50% of patients show insufficient response to traditional synthetic disease‐modifying antirheumatic drugs. This study aims to elucidate differential molecular profiles of the mechanisms underlying drug responses through multi‐omics strategy.
Congcong Jian   +26 more
wiley   +1 more source

Macronutrient metabolism by the human gut microbiome: major fermentation by-products and their impact on host health

open access: yesMicrobiome, 2019
The human gut microbiome is a critical component of digestion, breaking down complex carbohydrates, proteins, and to a lesser extent fats that reach the lower gastrointestinal tract.
Kaitlyn Oliphant, E. Allen-Vercoe
semanticscholar   +1 more source

Pigment Epithelium‐Derived Factor Deficiency Impairs Hippocampal Glutamate Homeostasis and Cognitive Function by Downregulating Astrocytic GLT‐1

open access: yesAdvanced Science, EarlyView.
The chronic glutamate‐induced excitotoxicity hypothesis has profoundly informed the therapeutic strategies employed in Alzheimer’s disease (AD). This study shows pigment epithelium‐derived factor (PEDF) regulates astrocytic glutamate transporter‐1 (GLT‐1)‐mediated glutamate homeostasis and cognition. Reduced PEDF correlates with lower Mini‐Mental State
Jin‐Hui Shi   +15 more
wiley   +1 more source

Gut Microbiome: The Peacekeepers [PDF]

open access: yesScientific American, 2015
Amid the trillions of microbes that live in the intestines, scientists have found a few species that seem to play a key role in keeping us ...
openaire   +3 more sources

Life Factors and Melanoma: From the Macroscopic State to the Molecular Mechanism

open access: yesAdvanced Science, EarlyView.
Melanoma, an aggressive skin cancer, arises from dynamic interactions between genetic, environmental, and lifestyle factors. This review explores how age, gender, obesity, diet, exercise, smoking, alcohol, UV exposure, circadian rhythms, and medications influence melanoma risk and progression.
Hanbin Wang   +4 more
wiley   +1 more source

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