Results 181 to 190 of about 746,471 (377)
Gut microbiome influences efficacy of PD-1–based immunotherapy against epithelial tumors
Science, 2018 B. Routy, E. Le Chatelier, L. Derosa, Connie P. M. Duong, M. Alou, Romain Daillère, A. Fluckiger, M. Messaoudene, C. Rauber, M. Roberti, Marine Fidelle, C. Flament, V. poirier-colame, P. Opolon, C. Klein, Kristina Iribarren, L. Mondragón, N. Jacquelot, B. Qu, Gladys Ferrere, C. Clémenson, L. Mezquita, J. R. Masip, C. Naltet, S. Brosseau, C. Kaderbhai, C. Richard, H. Rizvi, F. Levenez, N. Galleron, B. Quinquis, N. Pons, B. Ryffel, V. Minard-Colin, P. Gonin, J. Soria, E. Deutsch, Y. Loriot, F. Ghiringhelli, G. Zalcman, F. Goldwasser, B. Escudier, M. Hellmann, A. Eggermont, D. Raoult, L. Albiges, G. Kroemer, L. Zitvogel +47 moresemanticscholar +1 more sourceLarge-scale association analyses identify host factors influencing human gut microbiome composition
Nature Genetics, 2020 A. Kurilshikov, C. Medina-Gomez, Rodrigo Bacigalupe, D. Radjabzadeh, J. Wang, A. Demirkan, C. L. Le Roy, J. R. Raygoza Garay, Casey T. Finnicum, Xingrong Liu, D. Zhernakova, M. Bonder, T. Hansen, F. Frost, M. Rühlemann, W. Turpin, Jee-Young Moon, Han-Na Kim, K. Lüll, Elad Barkan, Shiraz A. Shah, M. Fornage, Joanna Szopinska-Tokov, Zachary D. Wallen, D. Borisevich, L. Agréus, A. Andreasson, C. Bang, L. Bedrani, J. Bell, H. Bisgaard, M. Boehnke, D. Boomsma, R. Burk, A. Claringbould, K. Croitoru, G. Davies, C. V. van Duijn, L. Duijts, G. Falony, Jingyuan Fu, A. van der Graaf, T. Hansen, G. Homuth, D. Hughes, R. IJzerman, M. Jackson, V. Jaddoe, M. Joossens, T. Jørgensen, D. Keszthelyi, R. Knight, M. Laakso, M. Laudes, L. Launer, W. Lieb, A. Lusis, A. Masclee, H. Moll, Z. Mujagic, Qi Qibin, Daphna Rothschild, Hocheol Shin, S. Sørensen, C. Steves, J. Thorsen, N. Timpson, R. Tito, S. Vieira-Silva, U. Völker, H. Völzke, U. Võsa, K. Wade, Susanne Walter, Kyoko Watanabe, S. Weiss, F. Weiss, O. Weissbrod, H. Westra, G. Willemsen, H. Payami, D. Jonkers, A. Arias Vásquez, E. D. de Geus, K. Meyer, J. Stokholm, E. Segal, Elin Org, C. Wijmenga, Hyung-Lae Kim, R. C. Kaplan, T. Spector, A. Uitterlinden, F. Rivadeneira, A. Franke, M. Lerch, L. Franke, S. Sanna, M. D’Amato, O. Pedersen, A. Paterson, R. Kraaij, J. Raes, A. Zhernakova +103 moresemanticscholar +1 more source7‐Ketodeoxycholic Acid Promotes Colonic Mucosal Healing by Inducing Calcium Release from Endoplasmic Reticulum via the TGR5‐IP3R Pathway
Advanced Science, EarlyView.7‐KDCA functions by driving intestinal epithelial cell migration through induction of calcium release from the endoplasmic reticulum. The findings emphasize a previously unrecognized property of 7‐KDCA in regulating cell migration, a required process for effective epithelial restitution and repair that is particularly critical for patients with UC to ...Jing Zhang, Feng Jiang, Wenxin Xia, Yilei Guo, Yanrong Zhu, Mianjiang Zhao, Lingzi Xiao, Zhifeng Wei, Yufeng Xia, Yue Dai +9 morewiley +1 more sourceType 2 Diabetes‐Associated Phenylacetylglutamine Induces Deleterious Inflammation Cycle in Myeloid Cells through β2 Adrenergic Receptors and Impedes Wound Healing
Advanced Science, EarlyView.The microbiota‐derived metabolite phenylacetylglutamine (PAGln) is elevated in type 2 diabetes and tightly associated with poor healing in both diabetic and non‐diabetic human patients. PAGln promotes mouse inflammation and impairs healing through a transmissible β2‐adrenergic receptor–mediated trained‐immunity loop.Lu Huang, Xinran Ye, Chia‐Kang Ho, Ya Gao, Dongsheng Wen, Jiaming Sun, Yuxin Liu, Yangdan Liu, Guoyuan Wang, Yangbai Sun, Jinyan Zhang, Yifan Zhang, Qingfeng Li +12 morewiley +1 more sourceGut microbiome modulates response to anti–PD-1 immunotherapy in melanoma patients
Science, 2018 V. Gopalakrishnan, C. Spencer, L. Nezi, A. Reuben, M. Andrews, T. Karpinets, P. Prieto, D. Vicente, K. Hoffman, S. Wei, Alexandria P. Cogdill, L. Zhao, C. Hudgens, D. Hutchinson, T. Manzo, M. Petaccia de Macedo, T. Cotechini, T. Kumar, W. Chen, S. Reddy, R. S. Szczepaniak Sloane, J. Galloway-Peña, H. Jiang, P. Chen, E. Shpall, K. Rezvani, A. Alousi, R. Chemaly, S. Shelburne, L. Vence, P. Okhuysen, V. B. Jensen, A. Swennes, F. McAllister, E. Marcelo Riquelme Sanchez, Y. Zhang, E. Le Chatelier, L. Zitvogel, N. Pons, J. Austin-Breneman, L. Haydu, E. Burton, J. Gardner, E. Sirmans, J. Hu, A. Lazar, T. Tsujikawa, A. Diab, H. Tawbi, I. Glitza, W. Hwu, S. Patel, S. Woodman, R. Amaria, M. Davies, J. Gershenwald, P. Hwu, J. Lee, J. Zhang, L. Coussens, Z. Cooper, P. Futreal, C. Daniel, N. Ajami, J. Petrosino, M. Tetzlaff, P. Sharma, J. Allison, R. Jenq, J. Wargo +69 moresemanticscholar +1 more sourceSynergistic Promotion of Triple‐Negative Breast Cancer Tumorigenesis and Metastasis by Oral Polystyrene Nanoplastics Exposure via Alloprevotella‐Derived Glutamate and Platelet Activation
Advanced Science, EarlyView.Polystyrene nanoplastics (PS‐NPs) administered via oral exposure accelerate triple‐negative breast cancer (TNBC) progression by synergistically modulating gut microbiota‐derived glutamate production and platelet activation. This study uncovers a pivotal crosstalk between microbial metabolites and platelet‐tumor interactions, offering mechanistic ...Leilei Zhu, Peihao Xu, Mingyuan Zhou, Kewei Li, Shasha Tian, Xuemei Fan, Junling Liu, Baodong Ye, Zhishan Ding, Yingzhi Shen +9 morewiley +1 more sourcePolydopamine Nanodots Ameliorate Inflammatory Bowel Disease by Restoring Redox Homeostasis and Intestinal Microenvironment
Advanced Science, EarlyView.A novel melanin‐based therapeutic composed of ultrasmall polydopamine nanodots is employed as an efficient oral formulation for the targeted treatment of inflammatory bowel disease. The potential therapeutic mechanism of polydopamine nanodots mainly involves the elimination of excessive oxidative stress, the reduction of ROS‐mediated proinflammatory ...Zhen Ding, Xingfu Bao, Ying Zhao, Lin Bai, Jinming Zhang, Chengjing Xu, Tianyan Chen, Shuang Dai, Yufu Liu, Min Hu, Meng Qin, Zhen Liu +11 morewiley +1 more sourceThe Impact of a Consortium of Fermented Milk Strains on the Gut Microbiome of Gnotobiotic Mice and Monozygotic Twins [PDF]
, 2011 Nathan P. McNulty, Tanya Yatsunenko, Ansel Hsiao, Jeremiah J. Faith, Brian D. Muegge, Andrew L. Goodman, Bernard Henrissat, Raish Oozeer, Stéphanie Cools-Portier, Guillaume Gobert, Christian Chervaux, Dan Knights, Catherine Lozupone, Rob Knight, Alexis E. Duncan, James R. Bain, Michael J. Muehlbauer, Christopher B. Newgard, Andrew C. Heath, Jeffrey I. Gordon +19 moreopenalex +1 more sourceDiabetes and gut microbiome
Frontiers in MicrobiologyDiabetes mellitus represents a significant global health problem. The number of people suffering from this metabolic disease is constantly rising and although the incidence is heterogeneous depending on region, country, economic situation, lifestyle, diet and level of medical care, it is increasing worldwide, especially among youths and children ...Kateřina Olša Fliegerová, Tiziana Maria Mahayri, Tiziana Maria Mahayri, Hana Sechovcová, Hana Sechovcová, Chahrazed Mekadim, Jakub Mrázek, Radka Jarošíková, Radka Jarošíková, Michal Dubský, Vladimíra Fejfarová, Vladimíra Fejfarová +11 moreopenaire +2 more sourcesFaecalibaculum rodentium Alleviates Ionizing Radiation‐Induced Damage in Mice by Improving Intestinal Integrity and Hematopoiesis via Its Metabolite Butyrate
Advanced Science, EarlyView.The model shows the probiotics screening and underlying mechanisms of F. rodentiumn in alleviating IR‐induced tissue injury. Stress‐induced STAT3 mitochondria localization decreases F. rodentium abundance and butyrate concentration. Supplementation of F.Hanyong Zhu, Hui Guo, Na Sun, Rui Xiao, Binbin Ji, Ruihan Jiang, Fuxing Dong, Chen Yao, Xuerong Wang, Rongqing Li, Jie Zhao, Xueqin Li, Shengzhe Gong, Yongqin Qin, Xin Chen, Yuchen Pan, Takayuki Ikezoe, Jing Yang +17 morewiley +1 more source
