Results 191 to 200 of about 761,618 (380)

Large-scale association analyses identify host factors influencing human gut microbiome composition

Nature Genetics, 2020
A. Kurilshikov, C. Medina-Gomez, Rodrigo Bacigalupe, D. Radjabzadeh, J. Wang, A. Demirkan, C. L. Le Roy, J. R. Raygoza Garay, Casey T. Finnicum, Xingrong Liu, D. Zhernakova, M. Bonder, T. Hansen, F. Frost, M. Rühlemann, W. Turpin, Jee-Young Moon, Han-Na Kim, K. Lüll, Elad Barkan, Shiraz A. Shah, M. Fornage, Joanna Szopinska-Tokov, Zachary D. Wallen, D. Borisevich, L. Agréus, A. Andreasson, C. Bang, L. Bedrani, J. Bell, H. Bisgaard, M. Boehnke, D. Boomsma, R. Burk, A. Claringbould, K. Croitoru, G. Davies, C. V. van Duijn, L. Duijts, G. Falony, Jingyuan Fu, A. van der Graaf, T. Hansen, G. Homuth, D. Hughes, R. IJzerman, M. Jackson, V. Jaddoe, M. Joossens, T. Jørgensen, D. Keszthelyi, R. Knight, M. Laakso, M. Laudes, L. Launer, W. Lieb, A. Lusis, A. Masclee, H. Moll, Z. Mujagic, Qi Qibin, Daphna Rothschild, Hocheol Shin, S. Sørensen, C. Steves, J. Thorsen, N. Timpson, R. Tito, S. Vieira-Silva, U. Völker, H. Völzke, U. Võsa, K. Wade, Susanne Walter, Kyoko Watanabe, S. Weiss, F. Weiss, O. Weissbrod, H. Westra, G. Willemsen, H. Payami, D. Jonkers, A. Arias Vásquez, E. D. de Geus, K. Meyer, J. Stokholm, E. Segal, Elin Org, C. Wijmenga, Hyung-Lae Kim, R. C. Kaplan, T. Spector, A. Uitterlinden, F. Rivadeneira, A. Franke, M. Lerch, L. Franke, S. Sanna, M. D’Amato, O. Pedersen, A. Paterson, R. Kraaij, J. Raes, A. Zhernakova   +103 more
semanticscholar   +1 more source

The Gut Microbiome: A universe inside us

, 2023
For me personally, the topic of the gut microbiome represents one of my most long-standing scientific interests. In September 1992, I joined the junior scientific research community in the Department of Infectious Diseases at St. Petersburg Pediatric Medical University.
openaire   +2 more sources

Medicago Sativa L. Saponin‐Driven Lactobacillus Intestinalis Restores Intestinal Stemness in Naturally Aged Mice via the Bile Acid‐FXR‐Wnt Signaling Axis

Advanced Science, EarlyView.
This study examines the mechanism by which alfalfa saponin (AS) regulates intestinal stemness via modulation of the gut microbiota. The results indicate that AS significantly increases the abundance of Lactobacillus intestinalis, which subsequently activates Wnt signaling via bile acid metabolism and enhances intestinal stemness. These findings provide
Mengqi Liu, Jiamin Sun, Zuyang Jia, Yalei Cui, Xiaoyan Zhu, Zhichang Wang, Hao Sun, Boshuai Liu, Yinghua Shi   +8 more
wiley   +1 more source

Compositional and Functional Differences in the Human Gut Microbiome Correlate with Clinical Outcome following Infection with Wild-Type Salmonella enterica Serovar Typhi [PDF]

, 2018
Yan Zhang, Arthur Brady, Cheron Jones, Yang Song, Thomas C. Darton, Claire Jones, Christoph J. Blohmke, Andrew J. Pollard, Laurence S. Magder, Alessio Fasano, Marcelo B. Sztein, Claire M. Fraser   +11 more
openalex   +1 more source

Housing temperature plays a critical role in determining gut microbiome composition in research mice: Implications for experimental reproducibility

, 2023
Bonnie L. Hylander, Guanxi Qiao, Eduardo Cortes Gomez, Prashant Kumar Singh, Elizabeth A. Repasky   +4 more
openalex   +1 more source

Lactobacillus Salivarius‐Derived Indole‐3‐Acetic Acid Promotes AHR‐PARP1 Axis‐Mediated DNA Repair to Mitigate Intestinal Aging

Advanced Science, EarlyView.
Indole‐3‐acetic acid (IAA) acting as one of the aryl hydrocarbon receptor (AHR) endogenous ligands is identified to be derived from Lactobacillus salivarius via its catalytic enzyme (ALDH) rather than host cells. Lactobacillus salivarius and IAA supplementation effectively mitigate intestinal aging by facilitating AHR‐poly (ADP‐ribose) polymerase 1 ...
Zheng Cao, Cui Zhang, Hehua Lei, Weichuan Lin, Wenkai Yu, Xin Gao, Yanmeng He, Xinzhi Li, Qingwei Xiang, Zhiwen Zhang, Weifei Luo, Andrew D. Patterson, Limin Zhang, Gang Chen   +13 more
wiley   +1 more source

DR5 Governs Compound Exocytosis in Colonic Goblet Cells via TATA‐Box Binding Protein‐Dependent Bestrophin‐2 Transcriptional Regulation

Advanced Science, EarlyView.
DR5 knockout exhibits a thinner colonic mucus layer, leading to mild dysbiosis, increased susceptibility to Citrobacter rodentium invasion, and exacerbated epithelial injury. Mechanistically, DR5 binds transcription factor TBP, which regulates the expression of gene Best2 via its promoter.
Ying Wang, Xinyun Li, Yong Wang, Chuhe Yang, Xiaopei Gao, Ke Zhu, Yihang Ren, Jingxin Li, Chuanyong Liu, Bing Xue   +9 more
wiley   +1 more source

Gut Bacterium Lysinibacillus Sphaericus Exacerbates Aspirin‐induced Intestinal Injury by Production of Carboxylesterase EstB

Advanced Science, EarlyView.
Schematic overview illustrating the detrimental role of gut microbiota in aspirin‐induced intestinal injury. L. sphaericus and its secreted carboxylesterase EstB are identified as key drivers that catalyze aspirin hydrolysis into salicylic acid, thereby exacerbating intestinal injury. Inhibition of EstB by the dietary compound flavanomarein effectively
Zeyu Zhao, Qing Li, Xiaowu Bai, Ertao Zhai, Weigang Dai, Yan Qian, Tianhao Zhang, Zhixin Huang, Ziyu Huang, Fangang Meng, Jianhui Chen, Tao Zuo, Shirong Cai, Risheng Zhao   +13 more
wiley   +1 more source

Complete Genome Sequence and Genomic Characterization of Lactobacillus acidophilus LA1 (11869BP)

Frontiers in Pharmacology, 2018
Won-Hyong Chung, Jisu Kang, Jisu Kang, Mi Young Lim, Tae-joong Lim, Sanghyun Lim, Seong Woon Roh, Young-Do Nam, Young-Do Nam   +8 more
doaj   +1 more source

Consumption of a Western-Style Diet Modulates the Response of the Murine Gut Microbiome to Ciprofloxacin

, 2020
Damien J. Cabral, Jenna I. Wurster, Benjamin J. Korry, Swathi Penumutchu, Peter Belenky   +4 more
openalex   +1 more source