Results 111 to 120 of about 932,371 (335)

Gut microbiota functions: metabolism of nutrients and other food components

European Journal of Nutrition, 2017
The diverse microbial community that inhabits the human gut has an extensive metabolic repertoire that is distinct from, but complements the activity of mammalian enzymes in the liver and gut mucosa and includes functions essential for host digestion. As
I. Rowland, G. Gibson, A. Heinken, K. Scott, J. Swann, I. Thiele, K. Tuohy   +6 more
semanticscholar   +1 more source

Multitasking Smart Intestinal Capsule Robot: A Cutting‐Edge Platform for Sampling, Diagnosis, and Therapy

Advanced Robotics Research, EarlyView.
Gut microbiota and biomarkers are linked to diseases like neurological disorders and metabolic syndromes. Ingestible capsule robots enable minimally invasive gut health assessment. This article proposes a promising direction for the advancement of capsule robots, integrating in situ sampling, real‐time diagnostics, and personalized therapy.
Xizong Chen, Libing Huang, Lei Ren, Miao Wang   +3 more
wiley   +1 more source

Gut Microbiota as a Target for Preventive and Therapeutic Intervention against Food Allergy [PDF]

, 2017
The gut microbiota plays a pivotal role in immune system development and function. Modification in the gut microbiota composition (dysbiosis) early in life is a critical factor affecting the development of food allergy.
Aitoro, Rosita, Amoroso, Antonio, BERNI CANANI, Roberto, Cosenza, Linda, DI COSTANZO, Margherita, DI SCALA, Carmen, Ercolini, Danilo, Granata, Viviana, Montella, Mariangela, Nocerino, Rita, Paparo, Lorella, Trinchese, Giovanna   +11 more
core   +1 more source

Dietary cholesterol drives fatty liver-associated liver cancer by modulating gut microbiota and metabolites

Gut, 2020
Objective Non-alcoholic fatty liver disease (NAFLD)-associated hepatocellular carcinoma (HCC) is an increasing healthcare burden worldwide. We examined the role of dietary cholesterol in driving NAFLD–HCC through modulating gut microbiota and its ...
Xiang Zhang, O. Coker, E. Chu, Kaili Fu, H. C. Lau, Yi-Xiang J. Wang, A. Chan, Hong Wei, Xiaoyong Yang, J. Sung, Jun Yu   +10 more
semanticscholar   +1 more source

Dual‐Functional Ingestible Passive Capsules for High‐Throughput Intestinal Sampling with Sealed Containment and Targeted Drug Delivery

Advanced Robotics Research, EarlyView.
To address challenges in high‐throughput intestinal sampling with sealed containment and target drug delivery, we developed a dual‐functional ingestible passive capsule with a dual‐triggered control system based on pH‐response and mechanical actuation.
Libing Huang, Houyu Ling, Xizong Chen, Yufei Duan, Yu Liu, Shuntian Cai, Yandan Ren, Wenlong Li, Lei Ren, Miao Wang   +9 more
wiley   +1 more source

Development, opportunities, and challenges of siRNA nucleic acid drugs

Molecular Therapy: Nucleic Acids
Small interfering RNA (siRNA) drugs were first proposed in 1999. They have reached the market for administration to patients after more than 20 years of development.
Bowen Xiao, Shaopeng Wang, Yu Pan, Wenjun Zhi, Chensheng Gu, Tao Guo, Jiaqi Zhai, Chenxu Li, Yong Q. Chen, Rong Wang   +9 more
doaj   +1 more source

Multiomics Analyses Reveal an Essential Role of Tryptophan in Treatment of csDMARDs in Rheumatoid Arthritis

Advanced Science, EarlyView.
Rheumatoid arthritis is a disease characterized by joint inflammation. Approximately 50% of patients show insufficient response to traditional synthetic disease‐modifying antirheumatic drugs. This study aims to elucidate differential molecular profiles of the mechanisms underlying drug responses through multi‐omics strategy.
Congcong Jian, Jing Zhu, Jianhong Wu, Yan Zhang, Jianghua Chen, Huan Wang, Hengyan Liu, Ke Xu, Jiaxin Huang, Xiaoting Zhu, Yuanli Wei, Shilin Li, Tingting Wang, Xuan Huang, Qinghua Zou, Jie Zhang, Jiang Su, Xinming Du, Yaping Lu, Tianci Zhou, Yingtong Zhou, Minglong Tang, Bin Li, Xue Zhou, Qihao Wei, Qiulong Yan, Fanxin Zeng   +26 more
wiley   +1 more source

Microbial collaborations and conflicts: unraveling interactions in the gut ecosystem

Gut Microbes
The human gut microbiota constitutes a vast and complex community of microorganisms. The myriad of microorganisms present in the intestinal tract exhibits highly intricate interactions, which play a crucial role in maintaining the stability and balance ...
Shuang Wang, Lingyi Mu, Chong Yu, Yuting He, Xinliang Hu, Yanlei Jiao, Ziqiong Xu, Shaohui You, Shu-Lin Liu, Hongxia Bao   +9 more
doaj   +1 more source

Pre‐Administration of Akkermansia Muciniphila Prevents the Development of Severe Acute Graft‐Versus‐Host Disease in Systemic Organs

Advanced Science, EarlyView.
Akkermansia muciniphila, a next‐generation probiotic, alleviates acute graft‐versus‐host disease (aGvHD) following allogeneic hematopoietic stem cell transplantation (HSCT) by providing protective effects across multiple organs. Pre‐colonization with A.
Jeong‐Eun Han, Dae‐Seong Lee, Su‐Won Jeong, Ji‐Hyun Yun, Seomin Kang, Seoyoung Jang, EunAh Lee, Ju Hye Baek, Che Ok Jeon, Jin‐Woo Bae   +9 more
wiley   +1 more source

Streptomyces sp. BI87 from human gut: potent anticancer activities and divergence from known Streptomyces lineages

Microbiology Spectrum
Cancer is among the deadliest diseases with few truly curative therapies. Recent studies have shown that the human intestinal microbiota contains bacteria that exhibit potent suppressive effects on cancer or coordinate anticancer functions with the ...
Yu-Hui Wang, Hong-Tao Xu, Miao-Wei Liu, Bao-Juan Yuan, Xin-Yu Gao, Xing-Hua Zhang, Hong-Da Tian, Hao Yu, Jin-Ru Lai, Liang Liu, Randal N. Johnston, Gui-Rong Liu, Shu-Lin Liu   +12 more
doaj   +1 more source