Results 121 to 130 of about 306,961 (316)

A Chirality‐Converted Bacteriolytic Dodecapeptide Regulates Vibrio‐Induced Polymicrobial Infection and Ameliorates Invasion‐Associated Gut Microbiota Disequilibrium

Advanced Science, EarlyView.
Multidrug‐resistant Vibrio infections are rising rapidly and threaten coastal populations worldwide. This study introduces D‐zp37, a chirality‐engineered antimicrobial peptide with exceptional potency against resistant Vibrio species. D‐zp37 kills planktonic cells, blocks mixed‐species biofilms, disrupts essential bacterial stress responses, and shows ...
Ping Zeng, Qipeng Cheng, Xiaoxu Zhang, Honglan Wang, Jinghan Zhang, Xinyi Ding, Pengfei Zhang, Lanhua Yi, Kwok‐Yin Wong, Kin‐Fai Chan, Sheng Chen, Sharon Shui Yee Leung   +11 more
wiley   +1 more source

Gut Microbiota: An Immersion in Dysbiosis, Associated Pathologies, and Probiotics

The importance of the microbiome, particularly the gut microbiota and its implications for health, is well established. However, an increasing number of studies further strengthen the link between an imbalanced gut microbiota and a greater predisposition
Valentina Origüela, Alvaro Lopez-Zaplana   +1 more
core   +1 more source

Insights into the Role of Human Gut Microbiota in Clostridioides difficile Infection

, 2020
Clostridioides difficile infection (CDI) has emerged as a major health problem worldwide. A major risk factor for disease development is prior antibiotic use, which disrupts the normal gut microbiota by altering its composition and the gut’s ...
Melina Kachrimanidou, Eleftherios Tsintarakis   +1 more
core   +1 more source

Synthesis and properties of pentabutyryl glucose ester and its effects on the growth, liver and intestinal health, and gut microbiota of zebrafish (Danio rerio)

Water Biology and Security
Butyric acid and its derivatives are widely applied in aquaculture as an alternative to antibiotics, which are beneficial for the growth and health of aquatic animals.
Yanqing Li, Yulian Zeng, Daojun Li, Lijuan Yu, Qianwen Ding, Yalin Yang, Chao Ran, Yuanyuan Yao, Rolf Erik Olsen, Einar Ringø, Jihong Liu Clarke, Zhen Zhang, Zhigang Zhou   +12 more
doaj   +1 more source

Amuc_1473 Links Gut Microbes to Skeletal Homeostasis and Counteracts Multifactorial Osteoporosis

Advanced Science, EarlyView.
Amuc_1473, a previously uncharacterized protein enriched in Akkermansia muciniphila‐derived extracellular vesicles, is identified as a gut–bone messenger that promotes osteogenesis and inhibits osteoclastogenesis by engaging transcriptional and translational regulators in bone cells.
Shan‐Shan Rao, Hai‐Jin Zeng, Zun Wang, Chun‐Gu Hong, Yi‐Juan Tan, Yan‐Xin Duan, Jing‐Yao Luo, Ming‐Jie Luo, Yi‐Wei Liu, Xin Wang, Yi Luo, Teng‐Fei Wan, Yong Zhou, Zheng‐Guang Wang, Guo‐Wen Hu, Hao Yin, Xin‐Yue Hu, Zhen‐Xing Wang, Ze‐Hui He, Si‐Yi Cheng, Wei Du, Zhe Guan, Hai‐Li Lang, Hong‐Ji Liu, Jia Cao, Peng Chen, Jiang‐Hua Liu, Hui Xie, Chun‐Yuan Chen   +28 more
wiley   +1 more source

The Role of the Microbiota–Gut–Brain Axis and Antibiotics in ALS and Neurodegenerative Diseases

, 2020
The human gut hosts a wide and diverse ecosystem of microorganisms termed the microbiota, which line the walls of the digestive tract and colon where they co-metabolize digestible and indigestible food to contribute a plethora of biochemical compounds ...
Adil Mistry, George Perry, Robert Bonomo, Mark Obrenovich, Lorraine Sykes, Tara Tadimalla, Hayden Jaworski   +6 more
core   +1 more source

A Synergistic Hydrogel‐Microalgae Platform for Dual‐Targeting of Intestinal and Neuroimmune Dysfunction in Inflammatory Bowel Disease

Advanced Science, EarlyView.
A bioactive hydrogel incorporating Chlorella vulgaris and paeoniflorin within a carboxymethyl chitosan/sodium alginate matrix cross‐linked with genipin is developed for inflammatory bowel disease therapy. The hydrogel exhibits gastric stability and intestine‐responsive release.
Jing Lu, Kangyu Jin, Bing Chen, Ruoxi Wang, Fengling Hu, Shaohua Hu, Danni Zhong, Xiaoming Li, Min Zhou   +8 more
wiley   +1 more source

Design of Single‐Atom Nanozymes for Precision Treatment of Erectile Dysfunction with Integrated Single‐Cell RNA Sequencing and Machine Learning

Advanced Science, EarlyView.
It is innovatively utilized single‐cell RNA sequencing to explore the underlying causes of diabetes mellitus‐induced erectile dysfunction, followed by machine learning‐driven design of a single‐atom nanozyme (Fe‐DMOF) for precision treatment of erectile dysfunction.
Xiang Zhou, Xi Zhang, Sihan Chen, Mengchi Yu, Yilan Hu, Chi Gan, Xianghu Meng, Long Li, Ninghong Song   +8 more
wiley   +1 more source

Intestinal microbiota in healthy adults: temporal analysis reveals individual and common core and relation to intestinal symptoms

, 2011
BACKGROUND: While our knowledge of the intestinal microbiota during disease is accumulating, basic information of the microbiota in healthy subjects is still scarce.
Vos, W.M., de, Willem M de Vos, Immonen, Outi, Janne Nikkilä, de Vos Willem M., Jalanka-Tuovinen, J., Salonen Anne, Lahti Leo, Leo Lahti, Anne Salonen, Jalanka-Tuovinen, Jonna, de Vos, W.M., Airi Palva, Nikkilä Janne, Palva Airi, de Vos, Willem M., Immonen Outi, Kekkonen, Riina, Lahti, Leo, Palva, Airi, Kekkonen Riina, Nikkila, Janne, Jonna Jalanka-Tuovinen, Willem M. de Vos, Jalanka-Tuovinen Jonna, Riina Kekkonen, Outi Immonen, Salonen, Anne   +27 more
core   +1 more source

Systematic Insights into the Relationship between the Microbiota–Gut–Brain Axis and Stroke with the Focus on Tryptophan Metabolism

Metabolites
Stroke, as a serious cerebral vascular disease with high incidence and high rates of disability and mortality, has limited therapeutic options due to the narrow time window.
Xinyu Shen, Xiaoqin Mu
doaj   +1 more source