Results 1 to 10 of about 158,688 (116)

Sex modulates the long-term effects of delivery mode on microbiota–gut barrier crosstalk and colitis susceptibility in mice [PDF]

Gut Microbes
Sexual dimorphism and mode of delivery are key determinants of gut physiology and microbiota development and may differentially affect predisposition to gut-related diseases.
Bruna Maitan Santos, Jordi Estellé, Yuliaxis Ramayo-Caldas, Sead Chadi, Monica Barone, Florian Chain, Camille Kropp, Patrizia Bridigi, Philippe Langella, Rebeca Martín   +9 more
doaj   +2 more sources

Targeting the gut barrier for the treatment of alcoholic liver disease

Liver Research, 2017
Alcohol consumption remains one of the predominant causes of liver disease and liver-related death worldwide. Intriguingly, dysregulation of the gut barrier is a key factor promoting the pathogenesis of alcoholic liver disease (ALD).
Zhanxiang Zhou, Wei Zhong
doaj   +3 more sources

Repairing gut barrier by traditional Chinese medicine: roles of gut microbiota

Frontiers in Cellular and Infection Microbiology
Gut barrier is not only part of the digestive organ but also an important immunological organ for the hosts. The disruption of gut barrier can lead to various diseases such as obesity and colitis.
Yaochuan Zhou, Dandan Zhang, Hao Cheng, Jinlu Wu, Juan Liu, Wuwen Feng, Wuwen Feng, Cheng Peng, Cheng Peng   +8 more
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Understanding the potential causes of gastrointestinal dysfunctions in multiple system atrophy

Neurobiology of Disease, 2023
Multiple system atrophy (MSA) is a rare, progressive neurodegenerative disorder characterised by autonomic, pyramidal, parkinsonian and/or cerebellar dysfunction. Autonomic symptoms of MSA include deficits associated with the gastrointestinal (GI) system,
Colin F. Craig, David I. Finkelstein, Rachel M. McQuade, Shanti Diwakarla   +3 more
doaj   +1 more source

Intestinal Barrier and Permeability in Health, Obesity and NAFLD

Biomedicines, 2021
The largest surface of the human body exposed to the external environment is the gut. At this level, the intestinal barrier includes luminal microbes, the mucin layer, gastrointestinal motility and secretion, enterocytes, immune cells, gut vascular ...
Piero Portincasa, Leonilde Bonfrate, Mohamad Khalil, Maria De Angelis, Francesco Maria Calabrese, Mauro D’Amato, David Q.-H. Wang, Agostino Di Ciaula   +7 more
doaj   +1 more source

Loss of Gut Barrier Integrity In Lupus

Frontiers in Immunology, 2022
Systemic Lupus Erythematosus is a complex autoimmune disease and its etiology remains unknown. Increased gut permeability has been reported in lupus patients, yet whether it promotes or results from lupus progression is unclear.
Longhuan Ma, Laurence Morel
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Gut microbiome-mediated mechanisms in aging-related diseases: are probiotics ready for prime time?

Frontiers in Pharmacology, 2023
Chronic low-grade inflammation affects health and is associated with aging and age-related diseases. Dysregulation of the gut flora is an important trigger for chronic low-grade inflammation.
Jing Ren, Jing Ren, Huimin Li, Guixing Zeng, Boxian Pang, Boxian Pang, Qiuhong Wang, Junping Wei   +7 more
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Rhubarb Enema Improved Colon Mucosal Barrier Injury in 5/6 Nephrectomy Rats May Associate With Gut Microbiota Modification

Frontiers in Pharmacology, 2020
Chronic kidney disease (CKD) is often accompanied with colon mucosal barrier damage and gut microbiota disturbance, which strongly associate with up-regulated inflammation and kidney tubulointerstitial fibrosis.
Chunlan Ji, Chunlan Ji, Yusheng Deng, Aicheng Yang, Zhaoyu Lu, Zhaoyu Lu, Yang Chen, Xusheng Liu, Xusheng Liu, Lijuan Han, Chuan Zou, Chuan Zou   +11 more
doaj   +1 more source

The direct and gut microbiota-mediated effects of dietary bile acids on the improvement of gut barriers in largemouth bass (Micropterus salmoides)

Animal Nutrition, 2023
Fish gut barrier damage under intensive culture model is a significant concern for aquaculture industry. This study aimed to investigate the effects of bile acids (BAs) on gut barriers in Micropterus salmoides.
Rui Xia, Qingshuang Zhang, Dongmei Xia, Qiang Hao, Qianwen Ding, Chao Ran, Yalin Yang, Aizhi Cao, Zhen Zhang, Zhigang Zhou   +9 more
doaj   +1 more source

The stress polarity signaling (SPS) pathway serves as a marker and a target in the leaky gut barrier: implications in aging and cancer

Life Science Alliance, 2020
Using patient-derived organoids the authors show how a specialized polarity pathway protects our gut barrier from stress-induced collapse. Findings highlight both diagnostic and therapeutic potential of the pathway for treating gut barrier dysfunction in
Pradipta Ghosh, Lee Swanson, Ibrahim M Sayed, Yash Mittal, Blaze B Lim, Stella-Rita Ibeawuchi, Marc Foretz, Benoit Viollet, Debashis Sahoo, Soumita Das   +9 more
doaj   +1 more source