Results 41 to 50 of about 1,115,431 (287)

Bugs and the gut: breaking barriers to understanding [PDF]

Gut, 2001
See article on page 503 There has been a re-emergence of interest in the interplay between the faecal microbiota and its associated metabolisms and gastrointestinal function. This has recently been driven by the current interest in human and veterinary probiotics, and in the recent past by hypotheses which linked gut bacterial metabolism of ingested ...
openaire   +2 more sources

Strain-specific effects of Akkermansia muciniphila on the regulation of intestinal barrier

Food Science and Human Wellness, 2023
Akkermansia muciniphila, one of the most promising next-generation probiotics, was reported to exhibit beneficial modulatory effects on the gut barrier.
Yang Liu, Qing Liu, Chengcheng Zhang, Jianxin Zhao, Hao Zhang, Wei Chen, Qixiao Zhai   +6 more
doaj   +1 more source

E-cigarettes compromise the gut barrier and trigger inflammation

iScience, 2021
Summary: E-cigarette usage continues to rise, yet the safety of e-cigarette aerosols is questioned. Using murine models of acute and chronic e-cigarette aerosol inhalation, murine colon transcriptomics, and murine and human gut-derived organoids in co ...
Aditi Sharma, Jasper Lee, Ayden G. Fonseca, Alex Moshensky, Taha Kothari, Ibrahim M. Sayed, Stella-Rita Ibeawuchi, Rama F. Pranadinata, Jason Ear, Debashis Sahoo, Laura E. Crotty-Alexander, Pradipta Ghosh, Soumita Das   +12 more
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Protective Mechanism against Gut Barrier Dysfunction in Mesenteric Ischemia/Reperfusion

, 2012
Intestinal ischemia/reperfusion (I/R) results in mucosal barrier impairment and enhanced bacterial translocation (BT) into systemic circulation and extraintestinal visceral organs.
YU, LINDA CHIA-HUI, 余佳慧
core   +1 more source

Gastric Output of Pancreatic Secretory Trypsin-Inhibitor Is Increased by Misoprostol [PDF]

, 1991
Pancreatic secretory trypsin inhibitor (PSTI) is a potent protease inhibitor that also has growth promoting activity. It has recently been identified in the foveolar cells of the stomach, which secrete mucus.
Batten, J J, Calam, J, Freeman, T C, Vesey, D A, Batten, JJ, Baron, J H, Baron, JH, Playford, RJ, Fenn, GC, Freeman, TC, Beardshall, K, Playford, R J, Beardsall, K, Fenn, G C, Vesey, DA   +14 more
core   +1 more source

How the Interplay Between the Commensal Microbiota, Gut Barrier Integrity, and Mucosal Immunity Regulates Brain Autoimmunity

Frontiers in Immunology, 2019
The intestinal barrier provides the host with a strong defense line against the external environment playing also a pivotal role in the crosstalk between the gut microbiota and the immune system.
Martina Antonini, Marta Lo Conte, Chiara Sorini, Marika Falcone   +3 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Effects of probiotics in patients with diabetes mellitus type 2 : study protocol for a randomized, double-blind, placebo-controlled trial [PDF]

, 2013
Background: Low grade chronic inflammation is observed in patients with type 2 diabetes mellitus (T2DM). Endotoxin derived from gut bacteria may act as a potent inflammatory stimulant.
Majed S Alokail, Sabico, S, Yousef Al-Saleh, Sabico, Shaun, McTernan, PG, Alokail, MS, Nasser M Al-Daghri, Vanhoutte, Paul M., Alokail, Majed S., Al-Daghri, NM, Shaun Sabico, Alkharfy, KM, Vanhoutte, PMGR, Philip G McTernan, Al-Saleh, Yousef, Al-Daghri, Nasser M., Al-Saleh, Y, Alkharfy, Khalid M., McTernan, P. G. (Philip G.), Khalid M Alkharfy, Paul M Vanhoutte   +20 more
core   +1 more source