Results 31 to 40 of about 160,336 (258)
Ex vivo intestinal permeability assay (X-IPA) for tracking barrier function dynamics
npj Biofilms and Microbiomes, 2023 The intestinal epithelial barrier facilitates homeostatic host–microbiota interactions and immunological tolerance. However, mechanistic dissections of barrier dynamics following luminal stimulation pose a substantial challenge.
Hadar Bootz-Maoz +9 more
doaj +1 more source
Strain-specific effects of Akkermansia muciniphila on the regulation of intestinal barrier
Food Science and Human Wellness, 2023 Akkermansia muciniphila, one of the most promising next-generation probiotics, was reported to exhibit beneficial modulatory effects on the gut barrier.
Yang Liu +6 more
doaj +1 more source
Comparison of Efavirenz and Dolutegravir on Gut Microbiome and Gut Barrier Functions. [PDF]
ACS OmegaDolutegravir (DTG) is increasingly replacing efavirenz (EFV) as the recommended first-line antiretroviral therapy (cART) component due to its superior tolerance. However, both EFV-based and DTG-based cART regimens are associated with metabolic and neuropsychiatric disorders through mechanisms that remain poorly understood.
Huang YX +10 more
europepmc +4 more sources
E-cigarettes compromise the gut barrier and trigger inflammation
iScience, 2021 Summary: E-cigarette usage continues to rise, yet the safety of e-cigarette aerosols is questioned. Using murine models of acute and chronic e-cigarette aerosol inhalation, murine colon transcriptomics, and murine and human gut-derived organoids in co ...
Aditi Sharma +12 more
doaj +1 more source
Crossing barriers: infections of the lung and the gut [PDF]
Mucosal Immunology, 2009 Although known as respiratory pathogens, severe acute respiratory syndrome (SARS) and its sister coronaviruses frequently cause enteric symptoms. In addition, other classically non-enteric viruses (such as HIV and influenza) may also have enteric effects that are crucial in their pathogeneses.
openaire +3 more sources
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Frontiers in Immunology, 2019 The intestinal barrier provides the host with a strong defense line against the external environment playing also a pivotal role in the crosstalk between the gut microbiota and the immune system.
Martina Antonini +3 more
doaj +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Molecules, 2021 The gut epithelium is a mechanical barrier that protects the host from the luminal microenvironment and interacts with the gut microflora, which influences the development and progression of ulcerative colitis (UC).
Juan Zhang +7 more
doaj +1 more source
Bugs and the gut: breaking barriers to understanding [PDF]
Gut, 2001 See article on page 503 There has been a re-emergence of interest in the interplay between the faecal microbiota and its associated metabolisms and gastrointestinal function. This has recently been driven by the current interest in human and veterinary probiotics, and in the recent past by hypotheses which linked gut bacterial metabolism of ingested ...
openaire +2 more sources