Results 21 to 30 of about 160,336 (258)
Background and objectiveImpaired gut barrier contributes to the progression of type 2 diabetes mellitus (T2DM), and the gut microbiota and metabolome play an important role in it.
Huan Liu +4 more
doaj +1 more source
Maintenance of intestinal homeostasis by mucosal barriers
Background The intestine is inhabited by a tremendous number of microorganisms, which provide many benefits to nutrition, metabolism and immunity. Mucosal barriers by intestinal epithelial cells make it possible to maintain the symbiotic relationship ...
Ryu Okumura, Kiyoshi Takeda
doaj +1 more source
The gut not only plays a key role in digestion and absorption of nutrients but also forms a physical barrier and first line of defense between the host and the luminal environment. A functional gut barrier (mucus and epithelial cells with tight junctions
Monika Proszkowiec-Weglarz +5 more
doaj +1 more source
Gut microbiome, endocrine control of gut barrier function and metabolic diseases [PDF]
Overweight and obesity are associated with several cardiometabolic risk factors, including insulin resistance, type 2 diabetes, low-grade inflammation and liver diseases. The gut microbiota is a potential contributing factor regulating energy balance.
Régnier, Marion +3 more
openaire +5 more sources
Age-related gut barrier dysfunction and dysbiosis of the gut microbiome play crucial roles in human aging. Dietary methionine restriction (MR) has been reported to extend lifespan and reduce the inflammatory response; however, its protective effects on ...
Bo Ren +6 more
doaj +1 more source
The Gut Immune Barrier and the Blood-Brain Barrier: Are They So Different? [PDF]
In order to protect itself from a diverse set of environmental pathogens and toxins, the body has developed a number of barrier mechanisms to limit the entry of potential hazards. Here, we compare two such barriers: the gut immune barrier, which is the primary barrier against pathogens and toxins ingested in food, and the blood-brain barrier, which ...
Daneman R, Rescigno M.
openaire +2 more sources
The Microbiota–Gut–Brain Axis and Diabetic Cognitive Impairment: A Memorable Journey
OBJECTIVE: Diabetes mellitus (DM) is associated with complications affecting the quality of life. Interestingly, the gut microbiota is closely related to glucose metabolism. This narrative review introduces the characteristics of the gut microbiota in DM,
Srinidhi Rai +4 more
doaj +1 more source
Introduction Breakdown of gut barrier integrity has been associated with inflammatory activation and is implicated in the etiology of several chronic medical conditions.
Vivian Feng +7 more
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People with human immunodeficiency virus (HIV) (PWH) have reduced gut barrier integrity (“leaky gut”) that permits diffusion of microbial antigens (microbial translocation) such as lipopolysaccharide (LPS) into the circulation, stimulating inflammation ...
Ronald J. Ellis +8 more
doaj +1 more source
Role of Gut Barrier Function in the Pathogenesis of Nonalcoholic Fatty Liver Disease
Nonalcoholic fatty liver disease (NAFLD) is one of the most common forms of chronic liver disease, and its incidence is increasing year by year. Many efforts have been made to investigate the pathogenesis of this disease.
Xin Dai, Bangmao Wang
doaj +1 more source

