Results 21 to 30 of about 1,115,431 (287)

Pathways involved in gut mucosal barrier dysfunction induced in adult rats by maternal deprivation: corticotrophin-releasing factor and nerve growth factor interplay [PDF]

, 2007
Neonatal maternal deprivation (NMD) increases gut paracellular permeability (GPP) through mast cells and nerve growth factor (NGF), and modifies corticotrophin-releasing factor (CRF) and corticosterone levels.
Lionel Bueno, Ferrier, Laurent, Fioramonti, Jean, Mathilde Leveque, Cartier, Christel, Frederick Barreau, Raphael Moriez, Valerie Laroute, Laurent Ferrier, Andras Rosztoczy, Christel Cartier, Leveque, Mathilde, Rosztoczy, Andras, Jean Fioramonti, Barreau, Frederick, Laroute, Valerie, Moriez, Raphael, Bueno, Lionel   +17 more
core   +1 more source

The Role of Gut Barrier Dysfunction and Microbiome Dysbiosis in Colorectal Cancer Development

Frontiers in Oncology, 2021
Accumulating evidence indicates that breakdown of the+ protective mucosal barrier of the gut plays a role in colorectal cancer (CRC) development. Inflammation and oxidative stress in the colonic epithelium are thought to be involved in colorectal ...
Flavia Genua, Vedhika Raghunathan, Mazda Jenab, William M. Gallagher, David J. Hughes   +4 more
doaj   +1 more source

Intestinal barrier function and absorption in pigs after waeaning: a review [PDF]

, 2011
Under commercial conditions, weaning of piglets is associated with social, environmental and dietary stress. Consequently, small-intestinal barrier and absorptive functions deteriorate within a short time after weaning.
Wijtten, P.J.A., Verstegen, M.W.A., Meulen, J., van der   +2 more
core   +1 more source

Gut-Brain Connection: Microbiome, Gut Barrier, and Environmental Sensors

Immune Network, 2021
The gut is an important organ with digestive and immune regulatory function which consistently harbors microbiome ecosystem. The gut microbiome cooperates with the host to regulate the development and function of the immune, metabolic, and nervous systems.
Min-Gyu Gwak, Sun-Young Chang
openaire   +2 more sources

Leaky Gut in IBD: Intestinal Barrier–Gut Microbiota Interaction

Journal of Microbiology and Biotechnology, 2022
Inflammatory bowel disease (IBD) is a global disease that is in increasing incidence. The gut, which contains the largest amount of lymphoid tissue in the human body, as well as a wide range of nervous system components, is integral in ensuring intestinal homeostasis and function.
Yu, Shunying, Sun, Yibin, Shao, Xinyu, Zhou, Yuqing, Yu, Yang, Kuai, Xiaoyi, Zhou, Chunli   +6 more
openaire   +2 more sources

The food contaminant deoxynivalenol, decreases intestinal barrier permeability and reduces claudin expression [PDF]

, 2009
The gastrointestinal tract represents the first barrier against food contaminants as well as the first target for these toxicants. Deoxynivalenol (DON) is a mycotoxin that commonly contaminates cereals and causes various toxicological effects.
Nougayrède, Jean-Philippe, Oswald, Isabelle P, Moreno, Carolina, Marin, Daniela E., Loureiro-Bracarense, Ana-Paula, Ferrier, Laurent, Oswald, Isabelle P., Pinton, Philippe, Del Rio, Juan-Carlos, Kolf-Clauw, Martine, Bracarense, Ana-Paula   +10 more
core   +1 more source

Roles and regulation of the mucus barrier in the gut [PDF]

Tissue Barriers, 2015
The gastrointestinal tract is coated by a thick layer of mucus that forms the front line of innate host defense. Mucus consists of high molecular weight glycoproteins called mucins that are synthesized and secreted by goblet cells and functions primarily to lubricate the epithelium and protect it from damage by noxious substances.
Steve, Cornick, Adelaide, Tawiah, Kris, Chadee   +2 more
openaire   +2 more sources

Effects of hemicellulose on intestinal mucosal barrier integrity, gut microbiota, and metabolomics in a mouse model of type 2 diabetes mellitus

Frontiers in Microbiology, 2023
Background and objectiveImpaired gut barrier contributes to the progression of type 2 diabetes mellitus (T2DM), and the gut microbiota and metabolome play an important role in it.
Huan Liu, Jihao Xu, Chiuwing Yeung, Qikui Chen, Jieyao Li   +4 more
doaj   +1 more source

Maintenance of intestinal homeostasis by mucosal barriers

Inflammation and Regeneration, 2018
Background The intestine is inhabited by a tremendous number of microorganisms, which provide many benefits to nutrition, metabolism and immunity. Mucosal barriers by intestinal epithelial cells make it possible to maintain the symbiotic relationship ...
Ryu Okumura, Kiyoshi Takeda
doaj   +1 more source

Effect of delayed feeding post-hatch on expression of tight junction– and gut barrier–related genes in the small intestine of broiler chickens during neonatal development11 Mention of trade name, proprietary product, or specific equipment does not constitute guarantee or warranty by USDA and does not imply its approval to the exclusion of other suitable products.

Poultry Science, 2020
The gut not only plays a key role in digestion and absorption of nutrients but also forms a physical barrier and first line of defense between the host and the luminal environment. A functional gut barrier (mucus and epithelial cells with tight junctions
Monika Proszkowiec-Weglarz, Lori L. Schreier, Stanislaw Kahl, Katarzyna B. Miska, Beverly Russell, Theodore H. Elsasser   +5 more
doaj   +1 more source