Results 21 to 30 of about 172,085 (298)
The Role of Gut Barrier Dysfunction and Microbiome Dysbiosis in Colorectal Cancer Development
Frontiers in Oncology, 2021 Accumulating evidence indicates that breakdown of the+ protective mucosal barrier of the gut plays a role in colorectal cancer (CRC) development. Inflammation and oxidative stress in the colonic epithelium are thought to be involved in colorectal ...
Flavia Genua +4 more
doaj +1 more source
Gut barrier function and the surgeon
Journal of British Surgery, 1990 Abstract There is accumulating evidence that multiple organ failure is not always the result of an established septic focus. Increasing attention has centred on the gut as a reservoir of bacteria (and bacterial endotoxins) that can traverse the intestinal mucosal barrier (a process called ‘bacterial translocation’) and initiate the ...
R, Saadia +3 more
openaire +2 more sources
Gut-Brain Connection: Microbiome, Gut Barrier, and Environmental Sensors
Immune Network, 2021 The gut is an important organ with digestive and immune regulatory function which consistently harbors microbiome ecosystem. The gut microbiome cooperates with the host to regulate the development and function of the immune, metabolic, and nervous systems.
Min-Gyu Gwak, Sun-Young Chang
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Pathways involved in gut mucosal barrier dysfunction induced in adult rats by maternal deprivation: corticotrophin-releasing factor and nerve growth factor interplay [PDF]
, 2007 Neonatal maternal deprivation (NMD) increases gut paracellular permeability (GPP) through mast cells and nerve growth factor (NGF), and modifies corticotrophin-releasing factor (CRF) and corticosterone levels.
Lionel Bueno +17 more
core +1 more source
Roles and regulation of the mucus barrier in the gut [PDF]
Tissue Barriers, 2015 The gastrointestinal tract is coated by a thick layer of mucus that forms the front line of innate host defense. Mucus consists of high molecular weight glycoproteins called mucins that are synthesized and secreted by goblet cells and functions primarily to lubricate the epithelium and protect it from damage by noxious substances.
Steve, Cornick +2 more
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Leaky Gut in IBD: Intestinal Barrier–Gut Microbiota Interaction
Journal of Microbiology and Biotechnology, 2022 Inflammatory bowel disease (IBD) is a global disease that is in increasing incidence. The gut, which contains the largest amount of lymphoid tissue in the human body, as well as a wide range of nervous system components, is integral in ensuring intestinal homeostasis and function.
Yu, Shunying +6 more
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The therapeutic management of gut barrier leaking: the emerging role for mucosal barrier protectors [PDF]
, 2015 Gut barrier is a functional unit organized as a multi-layer system and its multiple functions are crucial for maintaining gut homeostasis. Numerous scientific evidences showed a significant association between gut barrier leaking and gastro-intestinal ...
Lopetuso, Loris Riccardo +4 more
core +2 more sources
Frontiers in Microbiology, 2023 Background and objectiveImpaired gut barrier contributes to the progression of type 2 diabetes mellitus (T2DM), and the gut microbiota and metabolome play an important role in it.
Huan Liu +4 more
doaj +1 more source
The food contaminant deoxynivalenol, decreases intestinal barrier permeability and reduces claudin expression [PDF]
, 2009 The gastrointestinal tract represents the first barrier against food contaminants as well as the first target for these toxicants. Deoxynivalenol (DON) is a mycotoxin that commonly contaminates cereals and causes various toxicological effects.
Nougayrède, Jean-Philippe +10 more
core +1 more source
Gut microbiome, endocrine control of gut barrier function and metabolic diseases [PDF]
Journal of Endocrinology, 2021 Overweight and obesity are associated with several cardiometabolic risk factors, including insulin resistance, type 2 diabetes, low-grade inflammation and liver diseases. The gut microbiota is a potential contributing factor regulating energy balance.
Régnier, Marion +3 more
openaire +7 more sources