Results 61 to 70 of about 172,085 (298)

Enhancing intestinal barrier efficiency: A novel metabolic diseases therapy

Frontiers in Nutrition, 2023
Physiologically, the intestinal barrier plays a crucial role in homeostasis and nutrient absorption and prevents pathogenic entry, harmful metabolites, and endotoxin absorption.
Yaoyuan Zhang, Xiao Zhu, Xiao Zhu, Xinyuan Yu, Xinyuan Yu, Petr Novák, Petr Novák, Qingjun Gui, Qingjun Gui, Kai Yin   +9 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Persistent gut barrier damage and commensal bacterial influx following eradication of Giardia infection in mice

, 2014
Background: Recent studies of Giardia lamblia outbreaks have indicated that 40-80% of infected patients experience long-lasting functional gastrointestinal disorders after parasitic clearance.
倪衍玄 ;余佳慧 ;游偉絢 ;李宗錞, Chen, Tzu-Ling;Chen, Shin;Wu, Hsiu-Wei;Lee, Tsung-Chun;Lu, Yen-Zhen;Wu, Li-Ling;Ni, Yen-Hsuan;Sun, Chin-Hung;Yu, Wei-Hsuan;Buret, Andre G.;Yu, Linda Chia-Hui   +1 more
core   +1 more source

Deficiency of osteopontin in gut epithelial cells enhances intestinal integrity by promoting gut renewal through the JAK3/STAT4 pathway in acetaminophen (APAP)-induced acute liver injury

Cell Communication and Signaling
Gut barrier dysfunction is a key feature of acute liver injury (ALI) and leads to systemic immune responses (SIRS). Our previous studies have demonstrated that knockout of osteopontin (OPN) modulates antimicrobial peptide expression and reduces ...
Chang Yu, Yihan Qian, Yuge Zhou, Yali Sang, Weifan Huang, Limeng Yang, Liyue Lu, Xing Rong, Hailong Wu, Yanjun Shi, Xiaoni Kong   +10 more
doaj   +1 more source

The effects of fermentation products of prebiotic fibres on gut barrier and immune functions in vitro [PDF]

PeerJ, 2018
The beneficial effects of prebiotic fibres on human health have been related to their capacities to alter the gut microbiota and modify the growth of beneficial microorganisms.
Van T. Pham, Nicole Seifert, Nathalie Richard, Daniel Raederstorff, Robert E. Steinert, Kevin Prudence, M. Hasan Mohajeri   +6 more
doaj   +2 more sources

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Gastric Output of Pancreatic Secretory Trypsin-Inhibitor Is Increased by Misoprostol

, 1991
Pancreatic secretory trypsin inhibitor (PSTI) is a potent protease inhibitor that also has growth promoting activity. It has recently been identified in the foveolar cells of the stomach, which secrete mucus.
Batten, J J, Calam, J, Freeman, T C, Vesey, D A, Batten, JJ, Baron, J H, Baron, JH, Playford, RJ, Fenn, GC, Freeman, TC, Beardshall, K, Playford, R J, Beardsall, K, Fenn, G C, Vesey, DA   +14 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Impact of bioactive substances on the gastrointestinal tract and performance of weaned piglets: a review [PDF]

, 2009
The EU ban on in-feed antibiotics has stimulated research on weaning diets as a way of reducing post-weaning gut disorders and growth check in pigs. Many bioactive components have been investigated but only few have shown to be effective.
D. Torrallardona, S. J. Koopmans, Lalles, J.P., Janczyk, P., Koopmans, S. J., S.J. Koopmans, P. Janczyk, Lallès, J. P., Torrallardona, D., Bosi, P., Koopmans, S.J., P. Bosi, BOSI, PAOLO, Torrallardona, David, J.P. Lallès, J. P. Lallès   +15 more
core   +1 more source

Intestinal barrier damage caused by addictive substance use disorder

European Journal of Medical Research
Addictive substance use disorder has a wide range of effects on the intestinal barrier, including damage to the biological, chemical, mechanical, and immune barriers.
Yan Gao, Deshenyue Kong, Jia-xue Sun, Zhong-xu Ma, Guang-qing Wang, Xing-feng Ma, Liang Sun, Hua-you Luo, Yu Xu, Kun-hua Wang   +9 more
doaj   +1 more source