Results 61 to 70 of about 1,115,431 (287)

Bacterial extracellular vesicles – brain invaders? A systematic review

Frontiers in Molecular Neuroscience, 2023
IntroductionKnowledge on the human gut microbiota in health and disease continues to rapidly expand. In recent years, changes in the gut microbiota composition have been reported as a part of the pathology in numerous neurodegenerative diseases ...
Anna Kaisanlahti, Anna Kaisanlahti, Sonja Salmi, Sohvi Kumpula, Sohvi Kumpula, Sajeen Bahadur Amatya, Sajeen Bahadur Amatya, Jenni Turunen, Jenni Turunen, Mysore Tejesvi, Mysore Tejesvi, Nadiya Byts, Nadiya Byts, Terhi Tapiainen, Terhi Tapiainen, Terhi Tapiainen, Justus Reunanen, Justus Reunanen   +17 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Gut Microbiota and Immune System Interactions

, 2020
Dynamic interactions between gut microbiota and a host’s innate and adaptive immune systems are essential in maintaining intestinal homeostasis and inhibiting inflammation.
Maureen Groer, Anujit Sarkar, Ji Yoo, Samia Dutra, Daniel McSkimming   +4 more
core   +1 more source

Probiotic prophylaxis in predicted severe acute pancreatitis: a randomised, double-blind, placebo-controlled trial [PDF]

, 2008
: Background Infectious complications and associated mortality are a major concern in acute pancreatitis. Enteral administration of probiotics could prevent infectious complications, but convincing evidence is scarce. Our aim was to assess the effects of
van Eijck, Casper H. J., Rosman, Camiel, Schaapherder, Alexander F. M., Brink, M.A., van Ramshorst, B, Cuesta, Miguel A., van Santvoort, H.C., van Goor, H., Schaapherder, AFM, Besselink, Marc G. H., van der Harst, E, Cuesta, MA, Boermeester, Marja A., Boermeester, MA, van Eijck, CH, Witteman, Ben J. M., Schaapherder, A.F.M., Besselink, MGH, van der Harst, E., Akkermans, Louis M. A., van der Harst, Erwin, Buskens, E., Rosman, C., Dejong, C.H.C., Wahab, Peter J., Laarhoven, C.J.H.M. van, Nieuwenhuijs, V.B., Ploeg, RJ, Besselink, M.G.H., Witteman, BJM, Bollen, TL, Timmerman, Harro M., Timmerman, H.M., van Laarhoven, CJ, Ploeg, R.J., Dejong, CH, Buskens, Erik; id_orcid, Besselink, M.G., van Eijck, Casper, Van Eijck, GHJ, Timmerman, HM, Buskens, E, Gooszen, H.G., Van Laarhoven, CJHM, Akkermans, L.M., Grp, DAPS, Schaapherder, AF, Santvoort, H.C. van, Nieuwenhuijs, VB, Boermeester, M.A., Cuesta, M.A., Nieuwenhuijs, Vincent B., Bollen, T.L., Akkermans, LM, Wahab, PJ, Dejong, CHC, Gooszen, Hein G., van Ramshorst, B., Witteman, B.J., Akkermans, L.M.A., van Laarhoven, C.J.H.M., Dejong, C.H., Dejong, Cornelis H. C., Wahab, P.J., Eijck, C.H. van, van Laarhoven, C.J., Gooszen, HG, van der Harst, E (Erwin), Witteman, B.J.M., Bollen, Thomas L., Harst, E. van der, van Goor, H, Brink, M., van Ramshorst, Bert, Rosman, C, Buskens, Erik, van Laarhoven, Cees J. H. M., Brink, Menno A., Ramshorst, B. van, Ploeg, Rutger, van Goor, Harry, van Eijck, C.H.J., Goor, H. van, Besselink, MG, Brink, MA, Schaapherder, A.F., Akkermans, LMA, van Eijck, C.H., van Santvoort, HC, van Santvoort, Hjalmar C., Witteman, BJ, van Eijck, van, Ploeg, Rutger J.   +92 more
core   +2 more sources

Enhancing intestinal barrier efficiency: A novel metabolic diseases therapy

Frontiers in Nutrition, 2023
Physiologically, the intestinal barrier plays a crucial role in homeostasis and nutrient absorption and prevents pathogenic entry, harmful metabolites, and endotoxin absorption.
Yaoyuan Zhang, Xiao Zhu, Xiao Zhu, Xinyuan Yu, Xinyuan Yu, Petr Novák, Petr Novák, Qingjun Gui, Qingjun Gui, Kai Yin   +9 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Persistent gut barrier damage and commensal bacterial influx following eradication of Giardia infection in mice

, 2014
Background: Recent studies of Giardia lamblia outbreaks have indicated that 40-80% of infected patients experience long-lasting functional gastrointestinal disorders after parasitic clearance.
倪衍玄 ;余佳慧 ;游偉絢 ;李宗錞, Chen, Tzu-Ling;Chen, Shin;Wu, Hsiu-Wei;Lee, Tsung-Chun;Lu, Yen-Zhen;Wu, Li-Ling;Ni, Yen-Hsuan;Sun, Chin-Hung;Yu, Wei-Hsuan;Buret, Andre G.;Yu, Linda Chia-Hui   +1 more
core   +1 more source

The effects of fermentation products of prebiotic fibres on gut barrier and immune functions in vitro [PDF]

PeerJ, 2018
The beneficial effects of prebiotic fibres on human health have been related to their capacities to alter the gut microbiota and modify the growth of beneficial microorganisms.
Van T. Pham, Nicole Seifert, Nathalie Richard, Daniel Raederstorff, Robert E. Steinert, Kevin Prudence, M. Hasan Mohajeri   +6 more
doaj   +2 more sources

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source