Results 101 to 110 of about 306,961 (316)

The Role of Gut Microbiota in Intestinal Inflammation with Respect to Diet and Extrinsic Stressors

, 2019
The gut microbiota maintains a symbiotic relationship with the host and regulates several important functions including host metabolism, immunity, and intestinal barrier function.
Hyog Young Kwon, Yun Kyung Lee, Stefani Lobionda, Panida Sittipo   +3 more
core   +1 more source

Nesfatin-1 enhances vascular smooth muscle calcification through facilitating BMP-2 osteogenic signaling

Cell Communication and Signaling
Vascular calcification (VC) arises from the accumulation of calcium salts in the intimal or tunica media layer of the aorta, contributing to higher risk of cardiovascular events and mortality.
Xue-Xue Zhu, Xin-Yu Meng, Guo Chen, Jia-Bao Su, Xiao Fu, An-Jing Xu, Yao Liu, Xiao-Hui Hou, Hong-Bo Qiu, Qing-Yi Sun, Jin-Yi Hu, Zhuo-Lin Lv, Hai-Jian Sun, Hai-Bin Jiang, Zhi-Jun Han, Jian Zhu, Qing-Bo Lu   +16 more
doaj   +1 more source

Combination Immunotherapy as a Promising Strategy to Overcome Immunotherapy Resistance: From Emergence to Next‐Generation Approaches

Advanced Science, EarlyView.
This review examines emerging combination immunotherapy strategies tailored to distinct tumor microenvironments and highlights next‐generation biomarkers that guide response prediction and treatment personalization. It integrates lessons from unsuccessful trials, addresses toxicity challenges, and outlines approaches for early biomarker discovery and ...
Asmita Pandey, Sudhir Kumar Rai, Li Ma, Lauren Higa, Vedbar Khadka, Hua Yang, Youping Deng   +6 more
wiley   +1 more source

Trust Your Gut: The Association of Gut Microbiota and Liver Disease

, 2022
The gut microbiota composition is important for nutrient metabolism, mucosal barrier function, immunomodulation, and defense against pathogens. Alterations in the gut microbiome can disturb the gut ecosystem.
Memon, Hamda, Al Akeel, Mohannad, Afify, Nariman, Yasin, Maryam, Hamda Memon, Ridda Manzoor, Memon, Mashal, Rustom, Mohammad, Weshah Ahmed, Noora Alhajri, Nariman Afify, Mashal Memon, Mohannad Al Akeel, Alhajri, Noora, Ahmed, Weshah, Maryam Yasin, Mohammad Rustom, Manzoor, Ridda   +17 more
core   +1 more source

Sex‐Specific Regulation of Glycemic Homeostasis by Theabrownin from Pu‐erh Tea

Advanced Science, EarlyView.
Pu‐erh tea's key component, theabrownin (TB), lowers blood glucose in a sex‐specific manner. In females, estrogen boosts intestinal MUC2 production, which dramatically enhances TB's ability to inhibit the carbohydrate‐digesting enzyme α‐glucosidase.
Yang Li, Junliang Kuang, Dan Zheng, Jieyi Wang, Kun Ge, Chun Qu, Xiaojiao Zheng, Zhenxing Ren, Fengjie Huang, Mingliang Zhao, Yimin Sun, Huiheng Zhang, Keke Ding, Xixi Xia, Yajun Tang, Lu Liu, Jian Zhou, Fei Gao, Xiaohui Ma, Yongquan Xu, Guoxiang Xie, Aihua Zhao, Wei Jia   +22 more
wiley   +1 more source

Oral Bioinspired Peroxisome‐Engineered Probiotics for Modulating Gut Microbiota Homeostasis and Alleviating Cardiac Chemotherapy Toxicity

Advanced Science, EarlyView.
This study developed an oral bioinspired peroxisome‐engineered probiotic (BPEP) by anchoring lipid‐encapsulated ruthenium nanozymes onto Escherichia coli Nissle 1917, utilizing probiotics to deliver nanozymes to the intestinal barrier for reactive oxygen species/reactive nitrogen species elimination, tight junction restoration, and gut microbiota ...
Shuyu Wang, Xiaowan Fan, Chao Zhang, Shuai Han, Yike Guo, Yuchen Wang, Wei Wang, Junyue Xing, Ying Liu, Wei Jiang, Xiaoying Chen   +10 more
wiley   +1 more source

Dietary Organic Acids Modulate Gut Microbiota and Improve Growth Performance of Nursery Pigs

, 2021
Feed additives have been suggested to improve animal growth performance through modulating the gut microbiota. The hypothesis of this study was that the combination of two organic acids would exert synergistic effects on the growth performance and gut ...
Stein, Hans H., Hans H. Stein, Bradley, Casey L., Maxwell, Charles, Bottoms, Kristopher A., Joshua Knapp, Story, Robert, Jon Bergstrom, Xiaoyuan Wei, Bergstrom, Jon, Zhao, Jiangchao, Tsai, Tsungcheng, Charles Maxwell, Kristopher A. Bottoms, Jiangchao Zhao, Laia Blavi, Tsungcheng Tsai, Knapp, Joshua, Robert Story, Blavi, Laia, Casey L. Bradley, Wei, Xiaoyuan   +21 more
core   +1 more source

HMGCS2-dependent β-OHB/H3K9bhb ameliorates synaptic plasticity and cognition in Alzheimer’s disease

Experimental and Molecular Medicine
Ketogenic diet (KD) can significantly ameliorate cognition in Alzheimer’s disease (AD), but the specific mechanism is not clear. Histone3-lysine9-β-hydroxybutyrylation (H3k9bhb), a novel histone modification mark induced by ketogenesis-generated β ...
Haitao Yu, Fangzhou Wang, Jia-qi Yuan, Jia Chen, Ke-yu Zhang, Dongdong Jia, Juan Gong, Yuming Mao, Shuguang Bi, Yu-qi Zhang, Zi-chong Lan, Hao-yan Yu, Gao-shang Chai   +12 more
doaj   +1 more source

Icariin Enhances the Enzymatic Activity of N‐acetylgalactosaminidase to Augment Akkermansia Abundance in Gut Microbiota for Improved PD‐1 Blockade Efficacy in Tumor Suppression

Advanced Science, EarlyView.
Icariin promoted the growth of Akk by enhancing the activity of N‐acetylgalactosaminidase (Amuc_0920), which enhanced mucin utilization and provided a favorable nutrient environment for bacterial growth. This icariin‐mediated enrichment of Akk further reshaped the tumor microenvironment and promoted CD8+ T cell infiltration, ultimately synergizing with
Shuangying Qiao, Liu Yang, Haibang Hao, Qiuxia Ding, Feng Ding, Zheng Chen, Jinfang Zhang, Yun He, Meng Li, Jun Xu, Chao Wang, Aiping Lu, Fangfei Li   +12 more
wiley   +1 more source

Unraveling piglet gut microbiota dynamics in response to feed additives

, 2010
Keywords: GI tract, microbiota, pig, PITChip, weaning The gastrointestinal (GI) tract of pigs is colonized by a dense and metabolically active microbiota, comprising mainly bacteria, that have not only a commensal but a symbiotic (beneficial for both ...
Perez-Gutierrez, O.N.
core