Results 101 to 110 of about 715,974 (268)
HMGCS2-dependent β-OHB/H3K9bhb ameliorates synaptic plasticity and cognition in Alzheimer’s disease
Experimental and Molecular MedicineKetogenic diet (KD) can significantly ameliorate cognition in Alzheimer’s disease (AD), but the specific mechanism is not clear. Histone3-lysine9-β-hydroxybutyrylation (H3k9bhb), a novel histone modification mark induced by ketogenesis-generated β ...
Haitao Yu +12 more
doaj +1 more source
Advanced Science, EarlyView.In an invasive beetle–fungus complex, the mutualist Leptographium procerum induces host HSP83 and modulates Toll‐dependent antifungal immunity. HSP83 mediates two‐tiered control by associating with selected fungal recognition receptors and restraining Dorsal‐driven antimicrobial peptide transcription.
Qingtai Yang +8 more
wiley +1 more source
Frontiers in PharmacologyBackgroundNeuraminidase-1 (NEU1) is an enzyme that breaks down sialic acids on glycoproteins and glycolipids. Aberrant expression of NEU1 has been linked to the progression of numerous malignancies, including liver cancer. Oseltamivir phosphate (OP) is a
Yuyu Chen +10 more
doaj +1 more source
Advanced Science, EarlyView.After oral administration, inodorous GLU‐BA self‐assembles into nanomicelles in aqueous environments to resist premature gastric adsorption. Upon reaching the intestine, endogenous esterases rapidly cleave the built‐in ester bonds in these nanomicelles to release BA and GLU, with GLU further metabolized by gut microbiota to gradually generate BA ...
Feifei Xin +9 more
wiley +1 more source
Advanced Science, EarlyView.In colitis patients and mice, reduced Lactobacillus abundance is observed. Experimental studies show that L. plantarum A736 metabolizes dietary tryptophan into indole‐3‐lactic acid (ILA), while both L. plantarum A736 and ILA impact ChAT‐expressing enteric neurons and acetylcholine levels, thereby regulating intestinal immune responses and alleviating ...
Bing Xia +15 more
wiley +1 more source
AntioxidantsHyperuricemia (HUA) is a chronic metabolic disorder resulting from abnormal uric acid (UA) metabolism. Common clinical drugs for HUA have serious and inevitable adverse effects.
Xinyu Heng +10 more
doaj +1 more source
osu-cascades/gut-microbiota-mechanisms: v0.0.1
, 2018 An interactive model of gut microbiota mechanisms for restoring ...
Yong Joseph Bakos, ryder-mcdowell
core +1 more source
Advanced Science, EarlyView.Oligosaccharides with defined glycosidic bonds drive divergent gut microbial succession and shape unique metabolic profiles. Absolute time‐series profiling with Bayesian generalized Lotka–Volterra modeling identifies bond‐specific microbial responders, while monoculture validation and metaproteomics reveal linkage‐matched transport and cleavage modules.
Xiaoxuan Lu +10 more
wiley +1 more source
Development, opportunities, and challenges of siRNA nucleic acid drugs
Molecular Therapy: Nucleic AcidsSmall interfering RNA (siRNA) drugs were first proposed in 1999. They have reached the market for administration to patients after more than 20 years of development.
Bowen Xiao +9 more
doaj +1 more source
Gut Microbiota: An Immersion in Dysbiosis, Associated Pathologies, and Probiotics
The importance of the microbiome, particularly the gut microbiota and its implications for health, is well established. However, an increasing number of studies further strengthen the link between an imbalanced gut microbiota and a greater predisposition
Valentina Origüela +1 more
core +1 more source