Results 121 to 130 of about 693,536 (346)

Targeted Intervention Strategies for Maternal–Offspring Transmission of Christensenellaceae in Pigs via a Deep Learning Model

open access: yesAdvanced Science, EarlyView.
This study deciphers maternal‐driven microbial transmission in pigs using a deep learning model (maternal–offspring microbial transmission model), identifying Christensenellaceae R‐7 group as a key transmitted taxon. Filtered galacto‐oligosaccharides‐targeted Christensenellaceae R‐7 group alters offspring microbial functions via maternal ...
Haibo Shen   +9 more
wiley   +1 more source

Oligosaccharides from Gracilaria fisheri ameliorate gastrointestinal dysmotility and gut dysbiosis in colitis mice

open access: yesJournal of Functional Foods, 2020
Oligosaccharides from red algae have demonstrated prebiotic activity. In this study, the prebiotic effects of Gracilaria fisheri oligosaccharides (GFO) on gastrointestinal (GI) motility in acetic acid (AA)-induced colitis mice were investigated through ...
Sakena K-da   +5 more
doaj  

Lipid Droplet‐Organized MDM2‐Mediated P53 Degradation: A Metabolic Switch Governing Diet‐Driven Tumor Progression

open access: yesAdvanced Science, EarlyView.
Tumor‐associated TP53 inactivation correlates with lipid droplet (LD) accumulation. High‐fat diets drive Cyb5r3‐Myh9‐mediated p53 enrichment on LD surfaces, accelerating its degradation while upregulating LD‐promoting factor CD36 expression to establish a feed‐forward loop. LD suppression or dietary intervention restores p53 and inhibits tumorigenesis,
Haiyang Liu   +20 more
wiley   +1 more source

The crosstalk of intratumor bacteria and the tumor

open access: yesFrontiers in Cellular and Infection Microbiology
The in-depth studies reveal the interaction between the host and commensal microbiomes. Symbiotic bacteria influence in tumor initiation, progression, and response to treatment. Recently, intratumor bacteria have been a burgeoning research field.
Jiating Huang   +5 more
doaj   +1 more source

Research advances in the structure, function, and regulation of the gill barrier in teleost fish

open access: yesWater Biology and Security, 2023
The gill is an important organ in fish that is involved in various physiological functions, including respiration, filter-feeding, ammonia nitrogen excretion, and osmoregulation. The physiological functions of gills are closely related to their structure,
Xingyu Chen   +7 more
doaj  

The gut–liver axis and gut microbiota in health and liver disease

open access: yesNature Reviews Microbiology, 2023
Cynthia L. Hsu, B. Schnabl
semanticscholar   +1 more source

Bioinspired Claw‐Engaged Adhesive Microparticles Armed with γGC Alleviate Ulcerative Colitis via Targeted Suppression of Macrophage Ferroptosis

open access: yesAdvanced Science, EarlyView.
γGC deficiency in ulcerative colitis drives macrophage ferroptosis‐mediated inflammation. Claw‐engaged microparticles armed with γGC (γGC‐MPs) enhance lesion targeting, promoting localized γGC release and tissue uptake. On the cover, Monkey King (Macrophages) was bound by the Immortal‐Binding Rope and subsequently sealed beneath the Five‐Fingered ...
Rong Wang   +10 more
wiley   +1 more source

Integrative metagenomic analysis reveals distinct gut microbial signatures related to obesity

open access: yesBMC Microbiology
Obesity is a metabolic disorder closely associated with profound alterations in gut microbial composition. However, the dynamics of species composition and functional changes in the gut microbiome in obesity remain to be comprehensively investigated.
Xinliang Hu   +9 more
doaj   +1 more source

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