Results 121 to 130 of about 266,993 (291)

Oral Celastrol Nanomedicine Targeting Intestinal Antigen‐Presenting Cells to Effectively Mitigate Autoimmune Uveitis via Gut‐Retina Axis

Advanced Science, EarlyView.
Oral nanoCEL exhibits effective intestinal targeting of antigen‐presenting cells and restores the Th17/Treg balance in lymph nodes and spleen, ultimately protecting the blood‐retinal barrier by inhibiting peripheral immune cell infiltration and suppressing retinal glial cell activation.
Jinrun Chen, Yuqin Wu, Bofei Xu, Jiabei Hou, Yijing Li, Yuhan Hu, Yutuo Zhu, Wenqiao Zhang, Shuqi Feng, Huanting Jin, Yuchen Cheng, Yuanyuan Jin, Jianhong Zhou, Xingyi Li   +13 more
wiley   +1 more source

Guiqi Baizhu Decoction Alleviates Radiation Inflammation in Rats by Modulating the Composition of the Gut Microbiota [PDF]

, 2020
Liying Zhang, Ting Zhou, Yiming Zhang, Xiaomin Xu, Yangyang Li, Kong-Xi Wei, Jinpeng He, Nan Ding, Heng Zhou, Yongqi Liu   +9 more
openalex   +1 more source

Microglial GPR35 Ameliorates Epileptogenesis and Neuroinflammation via PDGFA Domain 2 Signaling

Advanced Science, EarlyView.
Activation of microglial G protein–coupled receptor 35 (GPR35) by L‐kynurenic acid (L‐Kyna) initiates a platelet‐derived growth factor A (PDGFA)–dependent phosphoinositide 3‐kinase–protein kinase B (PI3K–AKT) signaling cascade that dampens hippocampal neuroinflammation, thereby restraining epileptogenesis, lowering seizure susceptibility, and ...
Qi Wang, Tingting Qu, Qibing Sun, Ran Li, Junfei Dong, Yuming Du, Ziyin Xuan, Lei Wang, Hanli Li, Jianyun Sun, Fangliang Chen, Jinshuai Liu, Zifan Yang, Jianxiang Lei, Qian Yang, Bin Wang, Zhiming Zhou, Yu Wang   +17 more
wiley   +1 more source

Radix Pseudostellaria polysaccharides alleviate sepsis-induced liver injury by modulating the gut microbiota via the TLR4/NF-κB pathway [PDF]

Zhuolin Wang, Xiaohong Lin, Jianfeng Wu, Chanyuan Su, Yukun Luo, Guangwei Yu   +5 more
openalex   +1 more source

Mendelian randomization supports causality between gut microbiota and chronic hepatitis B [PDF]

, 2023
Quan-Zheng Zhang, Jinhua Zhou, Xiaoxiao Zhang, Rui Mao, Chuan Zhang   +4 more
openalex   +1 more source

Colorectal Cancer Cell's Weapon: RNF32 Engages SPP1+ Macrophages to Foster Liver Metastasis, Targeted by Indole‐3‐Acetic Acid

Advanced Science, EarlyView.
Cytoplasmic RNF32 fuels CRC liver metastasis by degrading GSK3β, which stabilizes β‐catenin and activates Wnt/EMT. Moreover, RNF32 rewires the metastatic niche: it depletes CD8+/CD4+ T and NK cells while recruiting SPP1+ macrophages (which boost tumor stemness via CD44), fibroblasts, and immunosuppressive monocytes to aid colonization.
Hongyu Wang, Shipeng Dai, Yuchen Xie, Pengyu Chen, Yue Chai, Chongyu Wang, Xueying Huang, Xiao Dong, Junfeng Shi, Yongxiang Xia, Xiaofeng Qian, Weiwei Tang, Yichan Zhou   +12 more
wiley   +1 more source

Targeted activation of ErbB4 receptor ameliorates neuronal deficits and neuroinflammation in a food-borne polystyrene microplastic exposed mouse model

Journal of Neuroinflammation
The impact of polystyrene microplastics (PS-MPs) on the nervous system has been documented in the literature. Numerous studies have demonstrated that the activation of the epidermal growth factor receptor 4 (ErbB4) is crucial in neuronal injury and ...
Chong Liu, Yan Zhao, Wei Zhang, Ji-Ji Dao, Qian Li, Jia Huang, Zhen-Feng Li, Yu-Ke Ma, Chen-Meng Qiao, Chun Cui, Shuang-Xi Chen, Li Yu, Yan-Qin Shen, Wei-Jiang Zhao   +13 more
doaj   +1 more source

From the Gut to the Brain: Microplastic‐Associated Neurovascular Dysfunction and Implications for Stroke Risk

Advanced Science, EarlyView.
Chronic oral exposure to microplastics may disrupt gut microbiota homeostasis and intestinal barrier integrity, potentially engaging the gut–brain axis and systemic inflammatory responses. These alterations may be associated with impaired blood–brain barrier function, cerebral microvascular dysfunction, and enhanced endothelial inflammation, pro ...
Hongxing Wang, Yujiao He, Pei Zou, Xiaoyi Wang, Gang Peng, Xiangying Deng   +5 more
wiley   +1 more source

Narrative Review: Gut Microbiota and Its Impact on α‐syn Function in Parkinson's Disease [PDF]

Isidro Daniel Salinas-Velarde, Juan Manuel Donaciano‐Domínguez, Rigoberto Oros‐Pantoja, José Félix Aguirre‐Garrido, Rina María González‐Cervantes, Jacobo Esteban Munguía‐Cervantes, Modesto Gómez López, Jaime Bustos‐Martínez, Alexandra Estela Soto‐Piña   +8 more
openalex   +1 more source

Lactobacillus rhamnosus GG triggers intestinal epithelium injury in zebrafish revealing host dependent beneficial effects

iMeta
Lactobacillus rhamnosus GG (LGG), the well‐characterized human‐derived probiotic strain, possesses excellent properties in the maintenance of intestinal homeostasis, immunoregulation and defense against gastrointestinal pathogens in mammals.
Zhen Zhang, Hong‐Ling Zhang, Da‐Hai Yang, Qiang Hao, Hong‐Wei Yang, De‐Long Meng, Willem Meindert de Vos, Le‐Luo Guan, Shu‐Bin Liu, Tsegay Teame, Chen‐Chen Gao, Chao Ran, Ya‐Lin Yang, Yuan‐Yuan Yao, Qian‐Wen Ding, Zhi‐Gang Zhou   +15 more
doaj   +1 more source