T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities
Advanced Science, EarlyView.T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu +7 more
wiley +1 more source
Preventive Effect of Peptidoglycan Extracted from Lactobacillus casei ATCC 393 on Dextran Sulfate Sodium-Induced Inflammation in Mice Through Gut Microbiota Regulation [PDF]
Ruiyi Li +6 more
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Advanced Science, EarlyView.ABSTRACT Inflammatory bowel disease (IBD) is a complex disorder characterized by chronic intestinal inflammation and impaired barrier function, for which effective long‐term therapies remain elusive. To address this challenge, we developed a novel nano‐vaccine that combines Prussian blue nanozymes (PBNZs) adjuvants with a ferritin carrier loaded with ...
Jingyi Sheng +6 more
wiley +1 more source
Gut microbiota promote the inflammatory response in the pathogenesis of systemic lupus erythematosus [PDF]
, 2019 Yiyangzi Ma +5 more
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Engineered Bacteria‐Vesicle Delivered Lactate Reprogramming Boosts Tumor Radiosensitivity
Advanced Science, EarlyView.We engineered a bacterial‐vesicular dual‐delivery platform that targets LOx to colorectal tumors, enabling lactate clearance, immune microenvironment remodeling, and microbiota modulation. This microbe–metabolism synergistic strategy effectively sensitizes colorectal cancer to radiotherapy, offering a promising approach to overcome radioresistance ...
Fei Peng +11 more
wiley +1 more source
Poria cocos as a Functional Food for Diabetes and Diabetes‐Related Foot Ulcers
AgriFood: Journal of Agricultural Products for Food, EarlyView.Poria cocos is known as an edible mushroom for food and medicine. Poria cocos and its terpenes and terpenoids serve as novel remedies to treat diabetes and its ulcers. Its mode of actions includes reduction of insulin resistance, starch digestion and inflammation as well as promotion of blood vessel formation. ABSTRACT Poria cocos is a medicinal fungus
Yi‐San Lee +3 more
wiley +1 more source
Hydroxyl Groups on the B Ring of Flavonols Significantly Impact the Energy and Lipid Metabolism in Mice: A Biochemical and Gut Microbiota Approach [PDF]
Weizhi Zhong +4 more
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Annals of Gastroenterological Surgery, EarlyView.We investigated the impact of temporary stoma creation and closure on gut microbiota diversity in rectal cancer patients. 16S rRNA sequencing revealed that microbial diversity significantly decreased postoperatively in the stoma group but remained stable in non‐stoma patients.
Yusuke Suzuki +9 more
wiley +1 more source
Berberine in Bowel Health: Anti-Inflammatory and Gut Microbiota Modulatory Effects [PDF]
Anna Duda-Madej +5 more
openalex +1 more source