Results 101 to 110 of about 89,407 (306)

Microbiota in Irritable Bowel Syndrome and Endometriosis: Birds of a Feather Flock Together—A Review

, 2023
Endometriosis and irritable bowel syndrome (IBS) are chronic conditions affecting up to 10% of the global population, imposing significant burdens on healthcare systems and patient quality of life. Interestingly, around 20% of endometriosis patients also
Francesco Vito Mandarino, Noemi Salmeri, Emanuele Sinagra, Massimo Candiani, Luca Massimino, Giovanni Buzzaccarini, Miriam Sutera, Carolina Dolci, Silvio Danese, Giulio Sozzi, Federica Ungaro   +10 more
core   +1 more source

Oral Bioinspired Peroxisome‐Engineered Probiotics for Modulating Gut Microbiota Homeostasis and Alleviating Cardiac Chemotherapy Toxicity

Advanced Science, EarlyView.
This study developed an oral bioinspired peroxisome‐engineered probiotic (BPEP) by anchoring lipid‐encapsulated ruthenium nanozymes onto Escherichia coli Nissle 1917, utilizing probiotics to deliver nanozymes to the intestinal barrier for reactive oxygen species/reactive nitrogen species elimination, tight junction restoration, and gut microbiota ...
Shuyu Wang, Xiaowan Fan, Chao Zhang, Shuai Han, Yike Guo, Yuchen Wang, Wei Wang, Junyue Xing, Ying Liu, Wei Jiang, Xiaoying Chen   +10 more
wiley   +1 more source

Effects of Maresin 1 (MaR1) on Colonic Inflammation and Gut Dysbiosis in Diet-Induced Obese Mice

, 2020
The aim of this study was to characterize the effects of Maresin 1 (MaR1), a DHA-derived pro-resolving lipid mediator, on obesity-related colonic inflammation and gut dysbiosis in diet-induced obese (DIO) mice.
Irene C. León, Sergio Quesada-Vázquez, Xavier Escoté, Elizabeth Guruceaga, Neira Sáinz, María Jesús Moreno-Aliaga   +5 more
core   +1 more source

Gut Microbiota–Gut Metabolites and Clostridioides difficile Infection: Approaching Sustainable Solutions for Therapy

Metabolites
Clostridioides difficile (C. difficile) infection (CDI) is the most common hospital-acquired infection. With the combination of a high rate of antibiotic resistance and recurrence, it has proven to be a debilitating public health threat.
Bijay Gurung, Maranda Stricklin, Shaohua Wang   +2 more
doaj   +1 more source

Icariin Enhances the Enzymatic Activity of N‐acetylgalactosaminidase to Augment Akkermansia Abundance in Gut Microbiota for Improved PD‐1 Blockade Efficacy in Tumor Suppression

Advanced Science, EarlyView.
Icariin promoted the growth of Akk by enhancing the activity of N‐acetylgalactosaminidase (Amuc_0920), which enhanced mucin utilization and provided a favorable nutrient environment for bacterial growth. This icariin‐mediated enrichment of Akk further reshaped the tumor microenvironment and promoted CD8+ T cell infiltration, ultimately synergizing with
Shuangying Qiao, Liu Yang, Haibang Hao, Qiuxia Ding, Feng Ding, Zheng Chen, Jinfang Zhang, Yun He, Meng Li, Jun Xu, Chao Wang, Aiping Lu, Fangfei Li   +12 more
wiley   +1 more source

Gut Microbiota during Dietary Restrictions: New Insights in Non-Communicable Diseases

, 2020
In recent decades, there has been a growing interest in dietary restrictions for their promising effects on longevity and health span. Indeed, these strategies are supposed to delay the onset and burden of non-communicable diseases (NCDs) such as obesity,
Antonio Gasbarrini, Marco Cintoni, Lucrezia Laterza, Maria Cristina Mele, Francesca Romana Ponziani, Pauline Raoul, Emanuele Rinninella, Gianluca Ianiro, Loris Riccardo Lopetuso   +8 more
core   +1 more source

Intervening Effects of Total Alkaloids of Corydalis saxicola Bunting on Rats With Antibiotic-Induced Gut Microbiota Dysbiosis Based on 16S rRNA Gene Sequencing and Untargeted Metabolomics Analyses

Frontiers in Microbiology, 2019
Gut microbiota dysbiosis induced by antibiotics is strongly connected with health concerns. Studying the mechanisms underlying antibiotic-induced gut microbiota dysbiosis could help to identify effective drugs and prevent many serious diseases.
Xi Liu, Hua Zheng, Rigang Lu, Huimin Huang, Hongjia Zhu, Chunli Yin, Yiyi Mo, Jinxia Wu, Xuwen Liu, Ming Deng, Danfeng Li, Bang Cheng, Fang Wu, Fang Wu, Yonghong Liang, Hongwei Guo, Hui Song, Zhiheng Su   +17 more
doaj   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Gut Microbiota: An Immersion in Dysbiosis, Associated Pathologies, and Probiotics

The importance of the microbiome, particularly the gut microbiota and its implications for health, is well established. However, an increasing number of studies further strengthen the link between an imbalanced gut microbiota and a greater predisposition
Valentina Origüela, Alvaro Lopez-Zaplana   +1 more
core   +1 more source

Dysbiosis of gut microbiota is associated with gastric carcinogenesis in rats

Biomedicine & Pharmacotherapy, 2020
Although many studies have examined changes in gut microbiota composition in gastric carcinogenesis to clarify the mechanism of action of anticancer drugs, it is unclear whether animal models of gastric carcinogenesis adequately reflect the disease in humans.To address this issue, the present study investigated changes in the gut microbiome profile of ...
Chunyue, Yu, Zeqi, Su, Yicong, Li, Yadong, Li, Kaige, Liu, Fuhao, Chu, Ting, Liu, Runhua, Chen, Xia, Ding   +8 more
openaire   +2 more sources