Results 141 to 150 of about 89,407 (306)

Chronic alcohol consumption compromises gut barrier integrity and promotes endotoxemia: Implications for sepsis susceptibility in immunocompromised hosts

Animal Models and Experimental Medicine, EarlyView.
Chronic alcohol exposure disrupts intestinal barrier integrity, resulting in a leaky gut and enhanced translocation of lipopolysaccharide (LPS) and microbial products into the systemic circulation. Alcohol‐induced endotoxemia drives exaggerated pro‐inflammatory responses, mitochondrial damage, and activation of the cGAS–STING pathway, particularly in ...
Thansita Bhunyakarnjanarat, Chatsuree Suksamai, Dhammika Leshan Wannigama, Kent Doi, Wiwat Chancharoenthana, Asada Leelahavanichkul   +5 more
wiley   +1 more source

Autoimmune Hepatitis: Shifts in Gut Microbiota and Metabolic Pathways among Egyptian Patients

, 2020
Autoimmune hepatitis (AIH) is a chronic inflammatory disorder with complex immunopathogenesis. Dysbiosis has been linked to many autoimmune diseases, but its detailed role in autoimmune hepatitis (AIH) still needs rigorous evaluation, especially in Egypt.
Elham A. Hassan, Abeer S. Abd El-Rehim, Helal F. Hetta, Mohammed Rammadan, Mohamed E. Ali, Ebtisam Hassanin, Wael A. Abbas, Nahla M. Elsherbiny, Mohamed A. A. Abozaid   +8 more
core   +1 more source

Exosome‐mediated gut–brain axis signaling in neurodegenerative diseases: Mechanisms, experimental evidence, and therapeutic perspectives—A narrative review

Animal Models and Experimental Medicine, EarlyView.
The gut–brain axis is a bidirectional communication network between the intestines and brain, mediated by gut microbiota and exosomes, that regulates neuroinflammation, protein aggregation, and neuronal health processes central to neurodegenerative diseases.
Waheeb Sami Aggad, Rakesh Ghosh, Hailah M. Almohaimeed, Zuhair M. Mohammedsaleh, Fayez M. Saleh, Amany I. Almars, S. Renuka Jyothi, Rajashree Panigrahi, Ajoy Kumer, Bikram Dhara   +9 more
wiley   +1 more source

Gut Microbiota Dysbiosis Facilitates Susceptibility to Bloodstream Infection

Journal of Microbiology
AbstractTo study the role of intestinal flora in the development of bloodstream infections (BSIs). 42 patients and 19 healthy controls (HCs) were screened into the study and their intestinal flora was measured by 16S rRNA gene sequencing. The bacterial diversity was significantly lower in the BSI group compared with that in the HCs (P < 0.001), and ...
Lin, Xiaomin, Lin, Chun, Li, Xin, Yao, Fen, Guo, Xiaoling, Wang, Meimei, Zeng, Mi, Yuan, Yumeng, Xie, Qingdong, Huang, Xudong, Jiao, Xiaoyang   +10 more
openaire   +2 more sources

Shotgun Metagenomic Profiling of the Gut Virome in Prodromal and Confirmed Parkinson's Disease

Annals of Neurology, EarlyView.
We conducted a nested case‐control study within the Nurses’ Health Study and the Health Professionals Follow‐up Study to examine the role of the gut virome (GV) in Parkinson's disease (PD). We applied a novel metagenomic virome profiling approach, Bioinformatic Application for Quantification and Labeling of Viral taxonomy (BAQLaVa), to prospectively ...
Deepika Dinesh, Xochitl C. Morgan, Jordan Jensen, Kjetil Bjornevik, Michael A. Schwarzschild, Alberto Ascherio, Curtis Huttenhower, Natalia Palacios   +7 more
wiley   +1 more source

Gut–Brain Axis Modulation by Short‐Chain Fatty Acids Exerts Disease‐Modifying Effects in a Murine Model of Drug‐Resistant Epilepsy

Annals of Neurology, EarlyView.
Objective Drug‐resistant epilepsy (DRE) remains a clinical challenge, as therapies modifying disease trajectory are lacking. Increasing evidence implicates gut microbiota dysbiosis in epilepsy pathophysiology, with short‐chain fatty acids (SCFAs) emerging as key microbial metabolites with neuroprotective and anti‐inflammatory properties.
Akash A. Bera, Rossella Di Sapia, Greta Volpedo, Sneha Anand, Eray Sahin, Pasquale Baldassarre, Francesca Buffelli, Andrea Petretto, Chiara Lavarello, James D. Mills, Gabriele Cattaneo, Ilaria Craparotta, Eleonora Aronica, Antonella Riva, Pasquale Striano, Annamaria Vezzani, Teresa Ravizza   +16 more
wiley   +1 more source

Deformed Wing Virus infection induces gut dysbiosis in honey bees

, 2023
Honey bee health decline represents a problem of global importance for the remarkable impact of these pollinators on the environment and human economy.
Davide Frizzera, Guido Favia, Giovanni Jesu, Andrea Becchimanzi, Giovanna De Leva, Desiderato Annoscia, Emilio Caprio, Francesco Pennacchio, Alfonso Cacace, Elisa Seffin, Ilaria Di Lelio, Francesco Nazzi, Claudia Damiani, Virginia Zanni   +13 more
core  

Dysbiosis and Schizophrenia: A Review of Current Evidence on the Gut–Brain Axis and Probiotic Interventions

Quality in Sport
Introdution: Schizophrenia is a complex mental disorder influenced by both genetic and environmental factors. Recent research has highlighted the potential role of the gut microbiota in mental health, including schizophrenia.
Anna Jakubiak, grzegorz Karaban, Michał Borawski, Aleksandra Ciuła, Joanna Miśkiewicz, Tadeusz Kuźnieców, Monika Paszkowska, Klaudia Mularczyk, Patrycja Znamirowska, Magdalena Kupis   +9 more
doaj   +1 more source

The Dynamic Interplay between the Gut Microbiota and Autoimmune Diseases

Journal of Immunology Research, 2019
The human gut-resident commensal microbiota is a unique ecosystem associated with various bodily functions, especially immunity. Gut microbiota dysbiosis plays a crucial role in autoimmune disease pathogenesis as well as in bowel-related diseases ...
Huihui Xu, Meijie Liu, Jinfeng Cao, Xiaoya Li, Danping Fan, Ya Xia, Xiangchen Lu, Jingtao Li, Dahong Ju, Hongyan Zhao   +9 more
doaj   +1 more source

Dietary Baicalin Supplementation Can Enhance the Growth Performance of Weaned Piglets and Maintain the Intestinal Barrier Integrity

Animal Research and One Health, EarlyView.
This research innovatively illustrates baicalin’s multifaceted mechanisms in enhancing piglets’ intestinal health: modulating bile acid metabolism via probiotics, reinforcing tight junction proteins (ZO‐1/claudin), suppressing TLR4/NF‐κB‐mediated inflammation, whereas promoting growth and reducing diarrhea.
Yuhui Gao, Jie Liu, Rui Yang, Xizhen Fan, Cheng Liang, Xin'e Shi, Jianjun Jin   +6 more
wiley   +1 more source