Results 101 to 110 of about 283,327 (339)

Linkage disequilibrium and haplotype block structure in Portuguese Holstein cattle

Czech Journal of Animal Science, 2018
The objectives of this study were to estimate linkage disequilibrium (LD), describe and scan a haplotype block for the presence of genes that may affect milk production traits in Portuguese Holstein cattle.
Mohamed Mahmoud Ibrahim Salem, Gertrude Thompson, Shanyuan Chen, Albano Beja-Pereira, Julio Carvalheira   +4 more
doaj   +1 more source

Identifying key DNA methylation sites and their cis-methylation quantitative loci for intramuscular fatty acid traits using genome and methylome data in Yorkshire pigs

Italian Journal of Animal Science, 2023
Single-nucleotide polymorphisms (SNPs) that are located near CpG sites have the potential to influence DNA methylation levels, leading to distinct patterns of DNA methylation.
Qi Shen, Kai Wang, Shujie Wang, Zhenjian Zhao, Xiang Ji, Dong Chen, Yang Yu, Shengdi Cui, Junge Wang, Ziyang Chen, Yiren Gu, Guoqing Tang   +11 more
doaj   +1 more source

Polygenic inheritance, GWAS, polygenic risk scores, and the search for functional variants

Proceedings of the National Academy of Sciences of the United States of America, 2020
The reconciliation between Mendelian inheritance of discrete traits and the genetically based correlation between relatives for quantitative traits was Fisher’s infinitesimal model of a large number of genetic variants, each with very small effects ...
Daniel J. M. Crouch, W. Bodmer
semanticscholar   +1 more source

Nonalcoholic Fatty Liver Disease Exacerbates the Advancement of Renal Fibrosis by Modulating Renal CCR2+PIRB+ Macrophages Through the ANGPTL8/PIRB/ALOX5AP Axis

Advanced Science, EarlyView.
The ANGPTL8/PIRB/ALOX5AP axis mediates liver‐kidney crosstalk. Hepatocytes secrete ANGPTL8, which binds to CCR2+PIRB+ macrophages in the kidneys, affecting the expression of ALOX5AP and enhancing the activation of these macrophages. Activated cells produce TGF‐β, IL‐6, and IL‐23, driving Th17 activation and promote the formation of myofibroblasts ...
Shuqi Wei, Diwen Shou, Siyuan Huang, Yingsi Wang, Quanzhen Liu, Jinfa Liu, Xiaoyu Lv, Yuyi Zeng, Liting Wei, Han Lin, Jiechuan Chen, Yangxiao Chen, Haoyu Zhong, Yanqing Zhou, Wen Ma, Li Wang, Guojun Qian, Jing Guo, Donglin Sun   +18 more
wiley   +1 more source

A Two-Stage Mutual Information Based Bayesian Lasso Algorithm for Multi-Locus Genome-Wide Association Studies

Entropy, 2020
Genome-wide association study (GWAS) has turned out to be an essential technology for exploring the genetic mechanism of complex traits. To reduce the complexity of computation, it is well accepted to remove unrelated single nucleotide polymorphisms ...
Hongping Guo, Zuguo Yu, Jiyuan An, Guosheng Han, Yuanlin Ma, Runbin Tang   +5 more
doaj   +1 more source

LD Hub: a centralized database and web interface to perform LD score regression that maximizes the potential of summary level GWAS data for SNP heritability and genetic correlation analysis

bioRxiv, 2016
Motivation LD score regression is a reliable and efficient method of using genome-wide association study (GWAS) summary-level results data to estimate the SNP heritability of complex traits and diseases, partition this heritability into functional ...
Jie Zheng, Mesut A. Erzurumluoglu, B. Elsworth, J. Kemp, L. Howe, P. Haycock, G. Hemani, K. Tansey, Charles Laurin, Early Genetics, Lifecourse Epidemiology Eczema Consortium, B. S. Pourcain, N. Warrington, H. Finucane, A. Price, B. Bulik-Sullivan, V. Anttila, L. Paternoster, Tom R. Gaunt, David M. Evans, B. Neale   +20 more
semanticscholar   +1 more source

Allelic Variation in Maize Malate Dehydrogenase 7 Shapes Promoter Methylation and Banded Leaf and Sheath Blight Resistance

Advanced Science, EarlyView.
In this study maize chloroplastic malate dehydrogenase7 (ZmMDH7), is identified as a Rhizoctonia solani resistance gene in maize. ZmMDH7 is regulated by transcription factor ZmWRKY44 via pathogens challenge to elevate mitochondrial ROS and SA signaling pathway.
Luyang Wei, Junbin Chen, Chuang Liu, DanDan Liu, Meida Du, Shengfeng He, Wenyu Cheng, Vijai Bhadauria, You‐Liang Peng, Wangsheng Zhu   +9 more
wiley   +1 more source

Rpv34: the noval Plasmopara viticola resistance locus in 'Moldova'

Fruit Research
Downy mildew (DM), caused by Plasmopara viticola, is one of the most serious diseases that affects grape production worldwide. Utilizing host resistance, commonly known as 'R' genes, is considered the most effective way to cure the disease.
Yan Sun, Bohan Yang, Minmin Li, Changjiang Liu, Yonggang Yin, Nan Jia, Xinyu Wang, Qingming Zeng, Yong Guo, Yingjie Wang, Guohong Wu, Qinqin Gu, Jianfeng Lou, Peining Fu, Bin Han   +14 more
doaj   +1 more source

Genome-Wide Association Study (GWAS) Identifies Key Candidate Genes Associated with Leaf Size in Alfalfa (Medicago sativa L.) [PDF]

, 2023
Ming Xu, Xueqian Jiang, Fei He, Bilig Sod, Tianhui Yang, Fan Zhang, Lili Cong, Ruicai Long, Mingna Li, Xue Wang, Qingchuan Yang, Tiejun Zhang, Junmei Kang   +12 more
openalex   +1 more source

Tractor uses local ancestry to enable inclusion of admixed individuals into GWAS and boost power

Nature Genetics, 2020
Admixed populations are routinely excluded from genomic studies due to concerns over population structure. Here, we present a statistical framework and software package, Tractor, to facilitate the inclusion of admixed individuals in association studies ...
Elizabeth G. Atkinson, A. Maihofer, M. Kanai, Alicia R. Martin, K. Karczewski, Marcos L. Santoro, J. Ulirsch, Y. Kamatani, Y. Okada, H. Finucane, K. Koenen, C. Nievergelt, M. Daly, B. Neale   +13 more
semanticscholar   +1 more source