Results 131 to 140 of about 283,327 (339)

15 years of GWAS discovery: Realizing the promise.

American Journal of Human Genetics, 2023
A. Abdellaoui, L. Yengo, K. Verweij, P. Visscher   +3 more
semanticscholar   +1 more source

Macrophagic Sclerostin Loop2‐ApoER2 Interaction Required by Sclerostin for Cardiovascular Protective Action

Advanced Science, EarlyView.
Sclerostin loop2‐ApoER2 interaction in macrophages is required by sclerostin to suppress NF‐κB nuclear translocation and phosphorylation, to promote macrophage conversion into anti‐inflammatory subtypes in atherosclerotic aortas, as well as to prevent atherosclerosis and aortic aneurysm development in ApoE−/− mice. Abstract Therapeutic antibody against
Luyao Wang, Xiaohui Tao, Ning Zhang, Xin Yang, Hewen Jiang, Xiaofei Li, Shenghang Wang, Shijian Ding, Sifan Yu, Huarui Zhang, Yihao Zhang, Nanxi Li, Haitian Li, Zhanghao Li, Xiaoxin Wen, Meiheng Sun, Chuanxin Zhong, Jin Liu, Yuanyuan Yu, Xianghang Luo, Tao Zhang, Shu Zhang, Péter Ferdinandy, Yu Huang, Daqing Ma, Aiping Lu, Baoting Zhang, Ge Zhang   +27 more
wiley   +1 more source

Artificial Intelligence for Bone: Theory, Methods, and Applications

Advanced Intelligent Discovery, EarlyView.
Advances in artificial intelligence (AI) offer the potential to improve bone research. The current review explores the contributions of AI to pathological study, biomarker discovery, drug design, and clinical diagnosis and prognosis of bone diseases. We envision that AI‐driven methodologies will enable identifying novel targets for drugs discovery. The
Dongfeng Yuan, Haicang Zhang, Liping Tong, Di Chen   +3 more
wiley   +1 more source

Oral Microbiota and Pharyngeal-Laryngeal Cancer Risk: Evidence from Mendelian Randomization in East Asian Populations

Polish Journal of Microbiology
Pharyngeal and laryngeal cancer (PLC) encompasses a range of aggressive malignancies associated with substantial clinical impact, underscoring the need for novel preventive and therapeutic measures.
FU JINGFENG
doaj   +1 more source

GWAS-Significant Loci and Uterine Fibroids Risk: Analysis of Associations, Gene-Gene and Gene-Environmental Interactions

Frontiers in Bioscience-Scholar
Background: Uterine fibroids (UF) is the most common benign tumour of the female reproductive system. We investigated the joint contribution of genome-wide association studies (GWAS)-significant loci and environment-associated risk ...
Liubov Ponomareva, Ksenia Kobzeva, Olga Bushueva   +2 more
doaj   +1 more source

Additional file 2 of A multilayered post-GWAS assessment on genetic susceptibility to pancreatic cancer

, 2021
Evangelina López de Maturana, Juan Antonio Rodríguez, Lola Alonso, Óscar Lao, Esther Molina‐Montes, Isabel Adoración Martín‐Antoniano, Paulina Gomez‐Rubio, Rita T. Lawlor, Alfredo Carrato, Manuel Hidalgo, Mar Iglesias, Xavier Molero, Matthias Löhr, Christopher Michalski, José Perea, Michael O’Rorke, Víctor Manuel Barberá, Adonina Tardón, Antoni Farré, Luis Muñoz‐Bellvís, Tanja Crnogorac-Jurcevic, J. Enrique Domínguez‐Muñoz, Thomas M. Gress, William Greenhalf, Linda Sharp, Luís Arnes, Lluís Cecchini, J. Balsells, Eithne Costello, Lucas Ilzarbe, Jörg Kleeff, Bo Kong, Mirari Márquez, Josefina Móra, Damian O’Driscoll, Aldo Scarpa, Weimin Ye, Jingru Yu, Montserrat García‐Closas, Manolis Kogevinas, Nathaniel Rothman, Debra T. Silverman, Demetrius Albanes, Alan A. Arslan, Laura E. Beane Freeman, Paige M. Bracci, Paul Brennan, Bas Bueno‐de‐Mesquita, Julie E. Buring, Federico Canzian, Margaret Du, Steve Gallinger, J. Michael Gaziano, Phyllis J. Goodman, Marc J. Gunter, Loı̈c Le Marchand, Donghui Li, Rachel Ε. Neale, Ulrika Peters, Gloria M. Petersen, Harvey A. Risch, María‐José Sánchez, Xiao‐Ou Shu, Mark Thornquist, Kala Visvanathan, Wei Zheng, Stephen J. Chanock, Douglas F. Easton, Brian M. Wolpin, Rachael Z. Stolzenberg‐Solomon, Alison P. Klein, Laufey T. Ámundadóttir, Marc A. Martı́-Renom, Francisco X. Real, Núria Malats   +74 more
openalex   +1 more source

Recent Advancements in Topic Modeling Techniques for Healthcare, Bioinformatics, and Other Potential Applications

Advanced Intelligent Systems, EarlyView.
This article offers a comprehensive review of topic modeling techniques, tracing their evolution from inception to recent developments. It explores methods such as latent Dirichlet allocation, latent semantic analysis, non‐negative matrix factorization, probabilistic latent semantic analysis, Top2Vec, and BERTopic, highlighting their strengths ...
Pratima Kumari, Sachin Kadian, Mukund Vora, Pradyumna Vemuri, Sumit Kumar, Om Prakash Verma, Roger J. Narayan   +6 more
wiley   +1 more source

Mainstream Artificial Intelligence Technologies in Contemporary Ophthalmology

Advanced Intelligent Systems, EarlyView.
This review explores the latest artificial intelligence (AI) technologies in ophthalmology, focusing on four key data types: medical imaging, electronic health records, robotic‐assisted surgery, and genomics. It examines the structural features, use cases, clinical goals, and evaluation metrics of various AI algorithms, while also introducing emerging ...
Shiqi Yin, Lei Wang, Shanjun Wu, Jiewei Jiang, Wei Qiang, Yangyang Wang, Shihong Wang, Yi Shao, Wei Chen, Zhongwen Li   +9 more
wiley   +1 more source

Correction to: Mapping of CaPP2C35 involved in the formation of light‑green immature pepper (Capsicum annuum L.) fruits via GWAS and BSA [PDF]

, 2021
Lang Wu, Haoran Wang, Sujun Liu, Mengmeng Liu, Jinkui Liu, Yihao Wang, Liang Sun, Wencai Yang, Huolin Shen   +8 more
openalex   +1 more source

GWAS-based Machine Learning for Prediction of Age-Related Macular Degeneration Risk [PDF]

, 2019
Qi Yan, Yale Jiang, Heng Huang, Anand Swaroop, Emily Y. Chew, Daniel E. Weeks, Wei Chen, Ying Ding   +7 more
openalex   +1 more source