Results 151 to 160 of about 133,124 (219)

Integrated Genomic and Transcriptomic Study Reveals <i>MAPK11</i> and <i>PER1</i> as Important Obesity Susceptibility Genes in a High-Risk Hispanic/Latino Population. [PDF]

Circ Genom Precis Med
Kim D, Polikowsky HG, Highland HM, Chen HH, Zhu W, Zhang X, Gillman MG, Frankel EG, Roshani R, Landman JM, Wang Y, Young KL, Anwar MY, Krishnan M, Buchanan VL, Berndt SI, Arias JD, Raffield LM, Gutierrez AD, Bishehsari F, Lee M, McCormick JB, Fisher-Hoch SP, Below JE, North KE, Graff M.   +25 more
europepmc   +1 more source

SPG4 Hereditary Spastic Paraplegia: From Etiology to Therapy

Movement Disorders, EarlyView.
Abstract Hereditary spastic paraplegias (HSPs) comprise a heterogeneous group of heritable neurodegenerative disorders resulting from mutations in a wide variety of genes. HSP locomotor symptoms include lower limb weakness and spasticity that arise from progressive degeneration of corticospinal axons projecting from the motor cortex to the distal ...
Emanuela Piermarini, Peter W. Baas
wiley   +1 more source

Past, present and future of local crop evolution

PLANTS, PEOPLE, PLANET, EarlyView.
Promoting agrobiodiversity is a promising strategy for mitigating the negative effects of climate change on global food security. We highlight the central role evolutionary processes play in harnessing the potential of local crops by integrating genomics, archaeology, ethnobotany and traditional ecological knowledge (TEK).
Nataly Allasi Canales, Philippa Ryan, Amy Jackson, Hong Phuong Le, James Borrell, Aaron Davis, Rafal M. Gutaker   +6 more
wiley   +1 more source

Multi-ancestry, trans-generational GWAS meta-analysis of gestational diabetes and glycaemic traits during pregnancy reveals limited evidence of pregnancy-specific genetic effects. [PDF]

Nat Commun
Brito Nunes C, Rukins V, Cisse AH, White F, McBride N, Kuang A, Allard C, Ronkainen J, Hughes A, Elliott A, Thorleifsson G, Vaudel M, Laisk T, Gu Y, Lamri A, Chen L, Tuhkanen J, Lahti J, Calas L, Muntaner M, Karhunen V, Choi J, Heiskala A, Hatem G, Fragoso-Bargas N, Rifas-Shiman SL, Paz-Lopez G, Stinson SE, Bhowmik B, Ahlqvist E, Estonian Biobank Research Team, Genes & Health Research Team, Deleuze JF, Eriksson JG, Park J, Teo K, Räikkönen K, Stefansson K, Molina-Vega M, Subbarao P, Beaumont RN, Johansson S, Tuomi T, Hansen T, Engelbrechtsen L, Morcillo S, Oken E, Quigstad E, Birkeland KI, Vääräsmäki M, Hattersley AT, Sebert S, Hitman GA, Kwak SH, Järvelin MR, Prasad RB, Heude B, Meirhaeghe A, Bouchard L, Jacques PÉ, Laivuori H, Tan KH, Anand SS, van Heel DA, Liu S, Njølstad PR, Steinthorsdottir V, Widén E, Keikkala E, Scholtens DM, Lowe WL, Finer S, Morris AP, Mägi R, Zöllner J, Borges MC, Lawlor DA, Hivert MF, Freathy RM, Evans DM, Moen GH.   +80 more
europepmc   +1 more source

Gene turnover in the common ancestor of all C4 grasses

PLANTS, PEOPLE, PLANET, EarlyView.
Understanding how plants evolve more efficient photosynthesis is important in a warming world where improving crop productivity and resilience is a global priority. By generating the first reference genomes for an early‐diverging group of grasses called the Aristidoideae, we were able to reconstruct the genetic makeup of the last common ancestor of all
Lara Pereira, Ahmed S. Alenazi, Sahr Mian, Ilia J. Leitch, Pascal‐Antoine Christin, Colin P. Osborne, Luke T. Dunning   +6 more
wiley   +1 more source

mFABIO: An integrative multi-tissue TWAS fine-mapping approach to prioritize potentially causal genes and tissues underlying binary traits. [PDF]

PLoS Genet
Zhang H, He K, Tsoi LC, Zhou X.
europepmc   +1 more source

From wild to tamed: Reimagining novel crops through omics and local plant diversity

PLANTS, PEOPLE, PLANET, EarlyView.
The global food system faces growing pressure from climate change, biodiversity loss, and rising nutritional demands. Agriculture has increased yields but reduced crop diversity, flavor, and nutritional quality, leaving societies vulnerable and dependent on a narrow set of staple species.
Alexandra Sanfeliu Meliá, Pablo D. Cárdenas   +1 more
wiley   +1 more source

Response to 'Impact of control selection strategies on GWAS results: a study of prostate cancer in the UK Biobank'. [PDF]

Brief Bioinform
Law PJ, Went M, Houlston RS.
europepmc   +1 more source

Exploring eco‐evolutionary and temporal patterns of arbuscular mycorrhizal fungal communities colonizing Sorghum bicolor across sites of contrasting land use history and climate

PLANTS, PEOPLE, PLANET, EarlyView.
Sorghum bicolor is a globally important cereal crop with annual yields exceeding 50 million tons across more than 100 countries and can be grown on marginal lands where conventional agriculture is limited. We examined how eight genetically diverse sorghum genotypes shaped arbuscular mycorrhizal fungal (AMF) community assembly across two contrasting ...
Philip Brailey‐Crane, Sedona M. Spann, Thomas H. Pendergast IV, Ben J. Long, Ashton K. Brinkley, Sarah R. Mondibrown, Nancy C. Johnson, Katrien M. Devos, Jeffrey L. Bennetzen   +8 more
wiley   +1 more source

Genome-wide association study of cocaine self-administration behavior in Heterogeneous Stock rats. [PDF]

Nat Commun
Lara MK, Carrette LLG, Sanches TM, Polesskaya O, Avelar A, Beeson A, Beldjoud H, Boomhower B, Brennan M, Chen D, Cheng R, China L, Chitre AS, Conlisk DE, Fannon M, Johnson BB, Keung E, Kimbrough A, Kononoff J, Martinez AR, Maturin L, Nguyen KM, Morgan A, Mosquera J, Othman D, Plasil SL, Ramborger J, Schweitzer P, Sedighim S, Seshie O, Shankar K, Sichel B, Simpson S, Smith LC, Sneddon EA, Tieu L, Velarde N, Zahedi S, Woods LCS, Kallupi M, de Guglielmo G, Palmer AA, George O.   +42 more
europepmc   +1 more source