Results 171 to 180 of about 174,316 (315)
Do Linking‐Expression Substitutions Mitigate Deterministic Interpretations of Genetic Information?
Journal of Applied Philosophy, EarlyView.ABSTRACT It is a common concern that broader audiences interpret scientific information about the genetic correlates and causes of complex human traits in an overly deterministic manner. A frequently proposed way to address this issue is to carefully select the linking expressions used to describe gene–trait relationships when communicating genetic ...
Riin Kõiv
wiley +1 more source
Journal of Clinical Laboratory Analysis, EarlyView.This study utilizes a two‐sample Mendelian randomization framework to establish a causal link between circulating inflammatory proteins, blood metabolites, and the risk of serous ovarian carcinoma. Our findings identify Interleukin‐8 as a significant risk factor and demonstrate that 1‐Palmitoyl‐GPG (16:0) acts as a metabolic mediator within this ...
Chong‐ze Yang +6 more
wiley +1 more source
JCPP Advances, EarlyView.Abstract Background Victimisation has been associated with self‐harm (with or without suicidal intent), but little is known about this association during young adulthood—a distinct developmental period. Further, not all individuals who experience victimisation will later engage in self‐harm, suggesting the influence of other factors.
Filip Marzecki +8 more
wiley +1 more source
JCPP Advances, EarlyView.This study found that youth with a higher genetic risk for internalizing and externalizing problems were more likely to face adversity within their home, highlighting the need for risk mitigation. These associations varied by adversity type and timing. Additionally, low family income, parental divorce, and externalizing behaviours were linked to lower ...
Christina Y. Cantave +3 more
wiley +1 more source
Navigating Mendelian Randomization in Sleep Medicine: Challenges, Opportunities, and Best Practices
Nature and Science of SleepAhmed S BaHammam,1,2 Haitham Jahrami3,4 1The University Sleep Disorders Center, Department of Medicine, College of Medicine, King Saud University, Riyadh, Saudi Arabia; 2King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia ...
BaHammam AS, Jahrami H
doaj
JCPP Advances, EarlyView.Abstract Background Children who show difficult temperament are at risk of peer victimisation, which in turn associates with numerous negative outcomes later in life. We used network analysis to examine whether specific aspects of difficult temperament contributed to these associations, and whether the links were moderated by variations in genetic ...
Tom C.‐H. Wu +5 more
wiley +1 more source
Exploring causal correlations between oily fish intake and multiple sclerosis: A two-sample Mendelian randomization study. [PDF]
Asia Pac J Clin NutrChang S, Shi K, Zhang M.
europepmc +1 more source
Isolating transdiagnostic effects reveals specific genetic profiles in psychiatric disorders
JCPP Advances, EarlyView.Abstract Background Evidence indicates substantial genetic overlap between psychiatric diagnoses. Accounting for these transdiagnostic effects can sharpen research on disorder‐specific genetic architecture and patterns of comorbidity. Methods We applied genomic structural equation modeling to genome‐wide association study summary statistics from 11 ...
Engin Keser +6 more
wiley +1 more source
Causal effects between blood metabolites and myocardial infarction: A 2-sample Mendelian randomization study. [PDF]
Medicine (Baltimore)Fu Y, Wei A, Wu W, Peng Z.
europepmc +1 more source