Results 171 to 180 of about 198,268 (313)

Chronic Prostatitis/Chronic Pelvic Pain Syndrome: Research Progress and Precision Diagnosis‐Therapy Under the Integrated Neuro–Immune–Metabolic–Microbiota Axis Framework

iMetaMed, EarlyView.
Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is increasingly recognized as a systemic disorder rather than a purely local prostate disease. The diagram illustrates the transition from the traditional local prostate‐centered model to a multi‐axis systemic framework involving clinical heterogeneity, local prostatic inflammation, systemic ...
Kun Wang, Jinfei Liu, Qiangsheng Wang, Lei Fan, Ziang Li, Xuexin Yu, Yonghao Chen, Xiaofan Lu, Guiyi Liao, Jialin Meng, Yu Guan   +10 more
wiley   +1 more source

Association of Lactate with Risk of Cardiovascular Diseases: A Two-Sample Mendelian Randomization Study

Vascular Health and Risk Management
Xindi Chang,* Wang Zheng,* Yingli Zhao, Wangkang Niku, Bing Deng, Ping Liu, Yiru Wang Department of Cardiology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, People’s Republic of China*These authors ...
Chang X, Zheng W, Zhao Y, Niku W, Deng B, Liu P, Wang Y   +6 more
doaj  

Polymorphic STRs represent unique genetic signals beyond SNPs associated with climate adaptation in Marchantia polymorpha

iMetaOmics, EarlyView.
Natural populations of Marchantia polymorpha sampled across contrasting climatic regions show clear geographic differentiation between Europe and Japan based on polymorphic short tandem repeat (STR) variation. Genome‐wide association (GWAS) analyses identified pSTR loci whose repeat‐length variation tracks temperature‐related WorldClim variables.
Shuangyang Wu, Shenghan Gao, Sen Wang, Martin Lascoux, Hao Yu   +4 more
wiley   +1 more source

Sorghum T2T pangenome highlights comprehensive genomic variation

iMetaOmics, EarlyView.
Three newly assembled telomere‐to‐telomere (T2T) genomes representing wild, landrace, and transformable germplasm were integrated with seven publicly available T2T genomes to construct a graph‐based pangenome. Comparative analyses revealed extensive centromere divergence, including distinct CEN137 monomer and CEN274 dimer organization, and showed that ...
Lihua Wang, Chuanzheng Wei, Hope O. Okunbor, Xiaofei Deng, Die Hu, Yongfei Wang, Junli Du, Ephrem Habyarimana, Yongfu Tao, Yi‐Hong Wang, Jieqin Li   +10 more
wiley   +1 more source

Multi-Trait GWAS Analyses of Blood Pressure Traits Provide Limited Gains in Locus Discovery or Polygenic Risk Score Performance Compared to Single-Trait GWAS. [PDF]

Genet Epidemiol
Ma Y, Argoty-Pantoja AD, Xie T, Barnes MR, Munroe PB, Cabrera CP, Snieder H, Warren HR, UMCG Genetics Lifelines Initiative (UGLI) group author: LifeLines Cohort Study.   +8 more
europepmc   +1 more source

Chicken‐linked multidrug‐resistant Campylobacter jejuni infections among Chinese children

iMetaOmics, EarlyView.
Campylobacter is a leading cause of pediatric diarrhea, but its genomic epidemiology and antimicrobial resistance in China remain poorly defined. We conducted genomic surveillance of 3492 children with diarrhea in two pediatric hospitals in Zhejiang Province in 2017, 2018, and 2021, combining culture, whole‐genome sequencing, and source‐attribution ...
Dongyan Shao, Yuchen Wu, Zhaoju Deng, Hanyu Wang, Can Cui, Jianzhong Shen, Julian Parkhill, Yang Wang, Rong Zhang, Dejun Liu   +9 more
wiley   +1 more source

Adjusting for Medication Use in GWAS and Its Impact on Mendelian Randomisation Analyses: An Example of Systolic Blood Pressure in UK Biobank. [PDF]

Genet Epidemiol
Yap AJY, Hanson AL, Griffith GJ, Sanderson E.   +3 more
europepmc   +1 more source

Artificial intelligence models Traditional Chinese Medicine principles to integrate with biomedicine

iMeta, EarlyView.
Using 26,339 model‐eligible Traditional Chinese Medicine (TCM) formula records, we trained an autoencoder following TCM's compression–expansion logic to learn the TCM embedding space (TCM‐ES), quantifying symptom‐pattern–formula mappings. TCM‐ES aligns with conventional TCM principles not used in training.
Haoran Li, Xingye Cheng, Ziyang Huang, Jingyuan Luo, Qianqian Xu, Qiguang Zhao, Tianchen Guo, Yumeng Zhang, Linda L. D. Zhong, Zhaoxiang Bian, Leihan Tang, Aiping Lyu, Liang Tian   +12 more
wiley   +1 more source

Genome-wide association analysis of resistance to scald in an adapted multiparent winter malting barley population. [PDF]

Plant Genome
Kolkman JM, Sepp SS, Kunze K, Bergstrom GC, Sorrells ME.   +4 more
europepmc   +1 more source

Ovarian Cancer: Epidemiology, Disease Mechanisms, New Diagnosis and Treatment Strategies, and Research Directions

iNew Medicine, EarlyView.
ABSTRACT Ovarian cancer (OC) continues to be the deadliest gynecological malignancy and a significant cause of cancer‐related mortality among women worldwide. Standard treatment strategies typically entail platinum‐based chemotherapy in conjunction with cytoreductive surgery.
Zunera Khalid, Weirong Fan, Farah Nazir, Yixiang Xing, Tengchuan Jin   +4 more
wiley   +1 more source