Results 181 to 190 of about 198,268 (313)

Extreme trait GWAS (Et-GWAS): Unraveling rare variants in the 3,000 rice genome

Identifying high-impact, rare genetic variants associated with specific traits is crucial for crop improvement. The 3,010 rice genome (3K RG) dataset offers a valuable resource for discovering genomic regions with potential applications in crop breeding.
Sinha, Pallavi, Dixit, Shalabh, Kumar, Arvind, Singh, Uma Maheshwer, Kalia, Sanjay, Gurjar, Anoop, Pahi, Bandana, Venkateshwarlu, Challa, Kumar, Ajay, Prasanth, Vinukonda Vishnu, Singh, Vikas Kumar, Sundaram, Krishna Tesman, Kohli, Ajay, Gnanapragasam, Niranjani   +13 more
core   +1 more source

Autoimmune diseases share a common genetic architecture involving the JAK-STAT pathway

EXCLI Journal : Experimental and Clinical Sciences
Iraj Saadat, Mostafa Saadat
doaj   +1 more source

Unraveling the shared genetic architecture of metabolic bone diseases via genomic structural equation modeling and multi-omics integration. [PDF]

PLoS One
Yi K, Wang F, Hu F, Tang W, Liu Y, Gao B, Zhang S, Jiang L, Ding J, Lei D, Yu J, Yu S, Wu B.   +12 more
europepmc   +1 more source

Phenotypic and Genotypic Analysis of Two Rare Cases of ‐‐SEA/‐α4.3 HbH Disease

Journal of Clinical Laboratory Analysis, EarlyView.
We report two unrelated adult patients with rare deletional HbH disease (genotype ‐‐SEA/‐α4.3). This novel 4.3 kb deletion covering the HBA1 gene is accompanied by X‐Y‐Z segment recombination, which was identified by CycloneSEQ long‐read nanopore sequencing.
Weijia Yang, Xiaoyan Huang, Li Zhang, Xiaoqin Yang, Yaya Guo, Qingping Kang, Min Dou, Guijun Huang   +7 more
wiley   +1 more source

Association Between Genetically Predicted 25-Hydroxyvitamin D and Type 2 Diabetes Risk in South Asians: An Exploratory Two-Sample Mendelian Randomization Study. [PDF]

Endocrinol Diabetes Metab
Zaka A, Khan S, Shah A, Khalid AA, Khalil I, Kamrul-Hasan ABM.   +5 more
europepmc   +1 more source

Exploratory Analysis of Ancestry‐Informed Polygenic Risk Scores in Korean Patients With Mature B‐Cell Neoplasms

Journal of Clinical Laboratory Analysis, EarlyView.
In 246 Korean patients with mature B‐cell neoplasms, ancestry‐informed PRS analysis using the 1000 Genomes East Asian population as an external reference showed only a modest overall case–reference difference. In contrast, phenotype‐matched PRS revealed the clearest and most consistent polygenic association in multiple myeloma, highlighting the ...
Youngeun Lee, Bo Ra Son, Yong‐Pyo Lee, Jihyun Kwon, Hee Sue Park   +4 more
wiley   +1 more source

An IRAT109 NAM population: Genetic characterization and mapping utility for trait dissection in japonica rice (Oryza sativa L.). [PDF]

Plant Genome
Quilloy FA, Vinarao R, Proud C, Nguyen TQC, Daygon D, Fukai S, Mitchell J.   +6 more
europepmc   +1 more source

Isolating transdiagnostic effects reveals specific genetic profiles in psychiatric disorders

JCPP Advances, EarlyView.
Abstract Background Evidence indicates substantial genetic overlap between psychiatric diagnoses. Accounting for these transdiagnostic effects can sharpen research on disorder‐specific genetic architecture and patterns of comorbidity. Methods We applied genomic structural equation modeling to genome‐wide association study summary statistics from 11 ...
Engin Keser, Wangjingyi Liao, Andrea G. Allegrini, Kaili Rimfeld, Thalia C. Eley, Robert Plomin, Margherita Malanchini   +6 more
wiley   +1 more source

Wie, was, GWAS?

InFo Hämatologie + Onkologie, 2022
openaire   +1 more source

Shared genetics between ADHD and reading/language abilities: Genome‐wide correlations, stratified enrichment, cross‐trait association, and mendelian randomization

JCPP Advances, EarlyView.
Abstract Background Attention‐deficit/hyperactivity disorder (ADHD) and language/reading difficulties frequently co‐occur. The extent of shared genetic architecture remains incompletely defined. We investigated genome‐wide overlap between ADHD and four core skills: word reading, nonword reading, spelling, and phoneme awareness.
Jinzhu Zhao, Shi Huang, Wei Liu, Feng Wang, Hong Qian, Xiaolin Hu   +5 more
wiley   +1 more source