Results 181 to 190 of about 241,345 (301)

Ordinal GWAS analysis of the frailty phenotype identified a novel locus at 12q22 that underscores the role of the neurological and immune systems. [PDF]

open access: yesNPJ Aging
Borhan S   +8 more
europepmc   +1 more source

Single‐Cell Transcriptomics and Deep Learning Link N‐(2‐Furoyl) Glycine to GLRX3 in Gastric Cancer

open access: yesMed Research, EarlyView.
ABSTRACT Gastric cancer remains a health burden, and its metabolic drivers are poorly defined. N‐(2‐furoyl) glycine, a circulating metabolite, has been implicated in tumor biology. We investigated its causal role in gastric cancer and the underlying mechanism.
Yingyi Zhang   +4 more
wiley   +1 more source

Genome-wide fine-mapping improves identification of causal variants. [PDF]

open access: yesNat Genet
Wu Y   +10 more
europepmc   +1 more source

Genome‐Wide Assessment Reveals Ancestral Differences in Homozygosity Patterns Potentially Linked to Parkinson's Disease Etiology

open access: yesMovement Disorders, EarlyView.
Abstract Background Recessive genetic variation and extended runs of homozygosity (ROHs) may contribute to the unexplained heritability of Parkinson's disease (PD), particularly in diverse and understudied populations. Objective We conducted the first large‐scale, multi‐ancestral investigation of PD to examine the impact of genome‐wide homozygosity on ...
Kathryn Step   +680 more
wiley   +1 more source

Correlation Between Gut Microbiota, Metabolites, and Diabetic Complications: A Two‐Sample Mendelian Randomization Study

open access: yesMedicine Advances, EarlyView.
Fang et al. demonstrate a significant causal relationship among gut microbiota, gut metabolites, and diabetic complications, highlighting a biological link underlying mechanisms of diabetic vascular diseases. These findings provide important implications for future therapeutic strategy and risk prediction.
Jiaxi Fang   +6 more
wiley   +1 more source

Uric Acid in Metabolic Dysfunction‐Associated Steatotic Liver Disease

open access: yesPortal Hypertension &Cirrhosis, EarlyView.
MASLD is the most prevalent chronic liver disease worldwide, yet effective pharmacological treatments remain limited. Hyperuricemia is now recognized as a key driver of hepatic steatosis, inflammation, and fibrosis, with elevated serum uric acid levels independently predicting hepatocellular carcinoma and liver‐related mortality.
Rong Wang   +5 more
wiley   +1 more source

Home - About - Disclaimer - Privacy