Results 201 to 210 of about 174,316 (315)

Neuroprotective effects of ursodeoxycholic acid in Parkinson's disease and Alzheimer's disease

Neuroprotection, EarlyView.
In Parkinson's disease (PD) and Alzheimer's disease (AD), various shared pathological mechanisms exist. UDCA has been shown to exert neuroprotective effects in preclinical and clinical studies. Such effects include the mitigation of neuroinflammation as well as rescue effects on mitochondrial dysfunction, oxidative stress, impaired autophagy, and ...
Ashley En Yi Chong, Andrew Octavian Sasmita, Rhun Yian Koh, Anna Pick Kiong Ling   +3 more
wiley   +1 more source

Multivariate genetic architecture of age-related eye disease. [PDF]

PLoS One
Gao L, Wang Q, Zhu C.
europepmc   +1 more source

Interaction Between Genetic Risk and Parental Feeding Practices in the Prediction of Overweight Across Adolescence

Obesity, EarlyView.
ABSTRACT Objective We examined whether genetic risk for higher BMI, parental feeding practices (restriction, pressure to eat, and monitoring), and their interactions were associated with overweight trajectories during adolescence. Methods Data came from 5568 participants aged 10–18 in the Twins' Early Development Study who had at least one measurement ...
Marthe de Roo, Tina Kretschmer, Clare Llewellyn, Bonamy R. Oliver, Catharina A. Hartman   +4 more
wiley   +1 more source

mFABIO: An integrative multi-tissue TWAS fine-mapping approach to prioritize potentially causal genes and tissues underlying binary traits. [PDF]

PLoS Genet
Zhang H, He K, Tsoi LC, Zhou X.
europepmc   +1 more source

Past, present and future of local crop evolution

PLANTS, PEOPLE, PLANET, EarlyView.
Promoting agrobiodiversity is a promising strategy for mitigating the negative effects of climate change on global food security. We highlight the central role evolutionary processes play in harnessing the potential of local crops by integrating genomics, archaeology, ethnobotany and traditional ecological knowledge (TEK).
Nataly Allasi Canales, Philippa Ryan, Amy Jackson, Hong Phuong Le, James Borrell, Aaron Davis, Rafal M. Gutaker   +6 more
wiley   +1 more source

Integrated Genomic and Transcriptomic Study Reveals <i>MAPK11</i> and <i>PER1</i> as Important Obesity Susceptibility Genes in a High-Risk Hispanic/Latino Population. [PDF]

Circ Genom Precis Med
Kim D, Polikowsky HG, Highland HM, Chen HH, Zhu W, Zhang X, Gillman MG, Frankel EG, Roshani R, Landman JM, Wang Y, Young KL, Anwar MY, Krishnan M, Buchanan VL, Berndt SI, Arias JD, Raffield LM, Gutierrez AD, Bishehsari F, Lee M, McCormick JB, Fisher-Hoch SP, Below JE, North KE, Graff M.   +25 more
europepmc   +1 more source

Gene turnover in the common ancestor of all C4 grasses

PLANTS, PEOPLE, PLANET, EarlyView.
Understanding how plants evolve more efficient photosynthesis is important in a warming world where improving crop productivity and resilience is a global priority. By generating the first reference genomes for an early‐diverging group of grasses called the Aristidoideae, we were able to reconstruct the genetic makeup of the last common ancestor of all
Lara Pereira, Ahmed S. Alenazi, Sahr Mian, Ilia J. Leitch, Pascal‐Antoine Christin, Colin P. Osborne, Luke T. Dunning   +6 more
wiley   +1 more source

LocusPackRat: an R package to support prioritizing candidate genes from large GWAS intervals with standardized evidence aggregation. [PDF]

G3 (Bethesda)
Gural B, Kimball T, Luu AN, Rau CD.
europepmc   +1 more source

GWAS

Japanese Journal of Allergology, 2016
openaire   +1 more source

From wild to tamed: Reimagining novel crops through omics and local plant diversity

PLANTS, PEOPLE, PLANET, EarlyView.
The global food system faces growing pressure from climate change, biodiversity loss, and rising nutritional demands. Agriculture has increased yields but reduced crop diversity, flavor, and nutritional quality, leaving societies vulnerable and dependent on a narrow set of staple species.
Alexandra Sanfeliu Meliá, Pablo D. Cárdenas   +1 more
wiley   +1 more source