Results 191 to 200 of about 191,618 (313)

Whole Exome Sequencing Identified a Novel Mutation in the LOXHD1 Gene in Consanguineous Iranian Families With Hearing Loss

Journal of Clinical Laboratory Analysis, EarlyView.
Whole exome sequencing in a consanguineous Iranian family with autosomal recessive non‐syndromic hearing loss revealed a novel homozygous frameshift mutation, c.3713dupA (p.Asp1238Glufs*10), in the LOXHD1 gene. This mutation, located in exon 24, results in a premature stop codon and a truncated protein. Sanger sequencing confirmed co‐segregation of the
Solmaz Hassani Fard Katiraei, Milad Gholami, Mohsen Soosanabadi, Mona Entezam, Seyed Alireza Dastgheib   +4 more
wiley   +1 more source

Isolating transdiagnostic effects reveals specific genetic profiles in psychiatric disorders

JCPP Advances, EarlyView.
Abstract Background Evidence indicates substantial genetic overlap between psychiatric diagnoses. Accounting for these transdiagnostic effects can sharpen research on disorder‐specific genetic architecture and patterns of comorbidity. Methods We applied genomic structural equation modeling to genome‐wide association study summary statistics from 11 ...
Engin Keser, Wangjingyi Liao, Andrea G. Allegrini, Kaili Rimfeld, Thalia C. Eley, Robert Plomin, Margherita Malanchini   +6 more
wiley   +1 more source

Genetic architectures of brain-related traits are shaped by strong selective constraints. [PDF]

Proc Natl Acad Sci U S A
Zhu H, Simons YB, Spence JP, Sella G, Pritchard JK.   +4 more
europepmc   +1 more source

Shared genetics between ADHD and reading/language abilities: Genome‐wide correlations, stratified enrichment, cross‐trait association, and mendelian randomization

JCPP Advances, EarlyView.
Abstract Background Attention‐deficit/hyperactivity disorder (ADHD) and language/reading difficulties frequently co‐occur. The extent of shared genetic architecture remains incompletely defined. We investigated genome‐wide overlap between ADHD and four core skills: word reading, nonword reading, spelling, and phoneme awareness.
Jinzhu Zhao, Shi Huang, Wei Liu, Feng Wang, Hong Qian, Xiaolin Hu   +5 more
wiley   +1 more source

Multiancestry genome-wide association and multiomics analyses elucidate spatiocellular features of multiple sclerosis genetics. [PDF]

Nat Genet
Fujimoto R, Ogawa K, Namba S, Ogawa Y, Edahiro R, Sonehara K, Tagawa S, Watanabe M, Yata T, Shirai Y, Yamamoto Y, Sato G, Kai C, Naito T, Hosokawa A, Yamamoto M, Japan MS/NMOSD Biobank, BioBank Japan Project, Matsuda K, Shimizu F, Kinoshita M, Mihara M, Nakamori M, Shimizu Y, Kawachi I, Miyamoto K, Niino M, Kumanogoh A, Nakatsuji Y, Matsushita T, Mochizuki H, Kira JI, Okuno T, Isobe N, Okada Y.   +34 more
europepmc   +1 more source

Editorial: Transdiagnostic approaches to child and adolescent mental health—Integrating development, dimensions, and mechanisms

JCPP Advances, EarlyView.
Abstract Co‐occurrence of child and adolescent neurodevelopmental and mental health conditions is the rule rather than the exception, yet translating this insight into shared frameworks and clinical practice remains challenging. In this Editorial, we are pleased to introduce the 26 papers included in the 2026 Special Issue of JCPP Advances.
Alessio Bellato, Stephen P. Becker, Catharina A. Hartman, Henrik Larsson, James J. Li, Samantha J. Lynch, Giorgia Michelini   +6 more
wiley   +1 more source

JanusX: an integrated and high-performance platform for scalable genome-wide association studies and genomic selection. [PDF]

Plant J
Fu J, Jia A, Wang H, Liu HJ.
europepmc   +1 more source

Shared genetic and molecular architecture between neurodevelopmental disorders and type 1 diabetes

Journal of Intelligent Medicine, EarlyView.
Abstract Epidemiological and clinical studies have suggested possible associations between type 1 diabetes (T1D) and neurodevelopmental disorders (NDDs), but these relationships remain inconsistent across disorders and populations. To clarify whether such mixed findings, we investigated the genetic architecture linking T1D with autism spectrum disorder
Jingxuan Zhang, Zhentao Zhou, Lirong Zhu, Wei Liu   +3 more
wiley   +1 more source

Integrated Genome-Wide Association Studies and Selection Signature Analysis Reveal the Genetic Architecture of the Wattle Trait in Goats. [PDF]

Anim Genet
Hu S, Wei C, Feng D, Gan S.
europepmc   +1 more source

Is quinoa‐farming sustainable in marginal environments? Social, economical and environmental aspects

Journal of the Science of Food and Agriculture, EarlyView.
Abstract Quinoa (Chenopodium quinoa Willd.) is an Andean grain crop introduced as a novel crop to many parts of the world in recent years. Recognized for nutritious seeds and high abiotic stress tolerance, it has been promoted as an element of climate‐resilient agriculture, particularly in marginal environments.
Anna Tabea Mengen, Damir Esenaliev, Jakhongir Babadjanov, Lukas John, Sandra M. Schmöckel, Botir Khaitov   +5 more
wiley   +1 more source