Results 191 to 200 of about 174,316 (315)

Single‐Cell Transcriptomics and Deep Learning Link N‐(2‐Furoyl) Glycine to GLRX3 in Gastric Cancer

Med Research, EarlyView.
ABSTRACT Gastric cancer remains a health burden, and its metabolic drivers are poorly defined. N‐(2‐furoyl) glycine, a circulating metabolite, has been implicated in tumor biology. We investigated its causal role in gastric cancer and the underlying mechanism.
Yingyi Zhang, Chenchen Wang, Tianliang Liu, Ziliang Wang, Zhe Zhang   +4 more
wiley   +1 more source

Private QTLs and the genetic architecture of hierarchical size traits: from body size to sex-specific plasticity. [PDF]

G3 (Bethesda)
Vea IM, Molina C, Wilcox AS, Frankino WA, Shingleton AW.   +4 more
europepmc   +1 more source

Omics GWAS: A Multi‐Omics Integrative Analysis Platform for Genome‐Wide Association Studies

Med Research, EarlyView.
ABSTRACT With the rapid advancement of genome‐wide association studies (GWAS), downstream analyses of GWAS data have become essential for elucidating the genetic mechanisms that underlie complex diseases. However, current post‐GWAS analyses face numerous challenges, including heterogeneous data formats, challenges in multi‐omics integration, and ...
Xu Zhang, Kailai Li, Yasi Zhang, Cenwen Liu, Shunyi Huang, Yingzhao Jin, Yugeng Gao, Quan Cheng, Yunyun Mei   +8 more
wiley   +1 more source

Multi-ancestry, trans-generational GWAS meta-analysis of gestational diabetes and glycaemic traits during pregnancy reveals limited evidence of pregnancy-specific genetic effects. [PDF]

Nat Commun
Brito Nunes C, Rukins V, Cisse AH, White F, McBride N, Kuang A, Allard C, Ronkainen J, Hughes A, Elliott A, Thorleifsson G, Vaudel M, Laisk T, Gu Y, Lamri A, Chen L, Tuhkanen J, Lahti J, Calas L, Muntaner M, Karhunen V, Choi J, Heiskala A, Hatem G, Fragoso-Bargas N, Rifas-Shiman SL, Paz-Lopez G, Stinson SE, Bhowmik B, Ahlqvist E, Estonian Biobank Research Team, Genes & Health Research Team, Deleuze JF, Eriksson JG, Park J, Teo K, Räikkönen K, Stefansson K, Molina-Vega M, Subbarao P, Beaumont RN, Johansson S, Tuomi T, Hansen T, Engelbrechtsen L, Morcillo S, Oken E, Quigstad E, Birkeland KI, Vääräsmäki M, Hattersley AT, Sebert S, Hitman GA, Kwak SH, Järvelin MR, Prasad RB, Heude B, Meirhaeghe A, Bouchard L, Jacques PÉ, Laivuori H, Tan KH, Anand SS, van Heel DA, Liu S, Njølstad PR, Steinthorsdottir V, Widén E, Keikkala E, Scholtens DM, Lowe WL, Finer S, Morris AP, Mägi R, Zöllner J, Borges MC, Lawlor DA, Hivert MF, Freathy RM, Evans DM, Moen GH.   +80 more
europepmc   +1 more source

Co‐ and Multi‐Pathologies in Parkinson's Disease: An International Parkinson and Movement Disorder Society Scientific Issues Committee Review

Movement Disorders, EarlyView.
Abstract Parkinson's disease (PD) has been historically defined as a disease of striatal dopamine deficiency secondary to degeneration of dopaminergic neurons in the substantia nigra pars compacta, related to the presence of Lewy bodies and Lewy neurites.
Michele Matarazzo, Per Borghammer, Inas Elsayed, Jennifer G. Goldman, Yue Huang, Katja Lohmann, Per Svenningsson, Lorraine V. Kalia, Daniela Berg, Jeffrey H. Kordower, the MDS Scientific Issues Committee   +10 more
wiley   +1 more source

Association of the Disheveled 2 (DVL2) Gene c.2044delC Variant with Increased Risk of Canine Cleft Palate. [PDF]

Anim Genet
Donner J, Hytönen M, Freyer J, Lohi H, Foran RC, Forman OP.   +5 more
europepmc   +1 more source

Correlation Between Gut Microbiota, Metabolites, and Diabetic Complications: A Two‐Sample Mendelian Randomization Study

Medicine Advances, EarlyView.
Fang et al. demonstrate a significant causal relationship among gut microbiota, gut metabolites, and diabetic complications, highlighting a biological link underlying mechanisms of diabetic vascular diseases. These findings provide important implications for future therapeutic strategy and risk prediction.
Jiaxi Fang, Leilei Zhai, Chan Huang, Liqin Li, Yong Wang, Jiaojiao Fan, Wei Zhou   +6 more
wiley   +1 more source

Depletion of microglial compensation in glial network: Disease‐associated response dynamics in the revised amyloid hypothesis

Neuroprotection, EarlyView.
The critical transition from amyloid pathology to irreversible neuronal loss in Alzheimer's disease hinges on the microglial response. This review aims to systematize the patterns of how microglia react within the glial context. Abstract Microglia mount coordinated, stage‐dependent compensatory programs in response to early amyloid β (Aβ) accumulation ...
Songtao Lei, Zixuan Huang, Wen Wang, Yan Meng   +3 more
wiley   +1 more source

Genome-wide association study of cocaine self-administration behavior in Heterogeneous Stock rats. [PDF]

Nat Commun
Lara MK, Carrette LLG, Sanches TM, Polesskaya O, Avelar A, Beeson A, Beldjoud H, Boomhower B, Brennan M, Chen D, Cheng R, China L, Chitre AS, Conlisk DE, Fannon M, Johnson BB, Keung E, Kimbrough A, Kononoff J, Martinez AR, Maturin L, Nguyen KM, Morgan A, Mosquera J, Othman D, Plasil SL, Ramborger J, Schweitzer P, Sedighim S, Seshie O, Shankar K, Sichel B, Simpson S, Smith LC, Sneddon EA, Tieu L, Velarde N, Zahedi S, Woods LCS, Kallupi M, de Guglielmo G, Palmer AA, George O.   +42 more
europepmc   +1 more source

Wie, was, GWAS?

InFo Hämatologie + Onkologie, 2022
openaire   +1 more source