Results 161 to 170 of about 133,124 (219)

Integrative Analysis of Plasma Proteome and Genome Reveals Novel Drug Targets for Chronic Rhinosinusitis and Nasal Polyps

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Background Chronic rhinosinusitis (CRS) and nasal polyps (NP) are chronic inflammatory conditions with unsatisfactory treatment outcomes due to frequent recurrence of refractory disease. Identifying new therapeutic targets is essential. Methods We conducted a proteome‐wide Mendelian randomization (MR) analysis by integrating genome‐wide ...
En Zhou, Shi Luo, Yu Xiao, Bin Liu, Xu‐Ping Xiao   +4 more
wiley   +1 more source

Sex Hormones and the Risk of Nasal Polyps: A Two‐Sample Mendelian Randomization Study

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Objective The pathophysiological roles of sex hormones in airway inflammation have drawn much attention recently. We aimed to explore the causal effect of sex hormones on chronic rhinosinusitis (CRS) and nasal polyps (NP) via a Mendelian randomization (MR) study.
Ying Zhu, Jia‐Yao Zhou, Shi‐Yao Zhang, Ru Tang, Chun‐Yu Luo, Yue‐Long Gu, Zhi‐Peng Li, Wei‐Tian Zhang   +7 more
wiley   +1 more source

Insights into the Cross-Population Transferability of Polygenic Scores for Substance Use. [PDF]

Behav Genet
Saunders GRB, Vrieze S, Liu DJ.
europepmc   +1 more source

Obstructive Sleep Apnea and BMI, Body Fat Percentage in the East Asian Population: A Bidirectional and Multivariate Mendelian Randomization Study

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Objective To explore the causal relationship between obstructive sleep apnea and body fat percentage and body mass index (BMI) in the East Asian population by using bidirectional Mendelian randomization and multivariate Mendelian randomization.
Rui Fan, Wen‐Jun Lu, Hua Zhang, Hai‐Ling Jiang, Tao Li, Yan Yan   +5 more
wiley   +1 more source

Integrative genetic and liver transcriptomic analyses identify TRIB1AL as a target for steatotic liver disease.

J Clin Endocrinol Metab
Gobeil É, Bourgault J, Gagnon E, Samson N, Ruel LJ, Côté V, Mitchell PL, Gotti C, Roux-Dalvai F, Droit A, Bossé Y, Mathieu P, Lajeunesse-Trempe F, Vohl MC, Caron A, Tchernof A, Thériault S, Laplante M, Arsenault BJ.   +18 more
europepmc   +1 more source

Optimized post-GWAS analysis identifies therapeutic targets for essential thrombocythemia and polycythemia vera. [PDF]

Commun Med (Lond)
Li X, An W, Wang X, Yin Z, Gao Y, Lan Y, Zhang L, Zhao B, Chang L, Ruan M, Zhang L, Zou Y, Yang W, Zhu X.   +13 more
europepmc   +1 more source

The Relationship Between Blood Lipids, Coagulation Indexes, Blood Homocysteine and Sudden Deafness: A Retrospective Study and Mendelian Randomization Analysis

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Background Certain blood components, including blood lipids, coagulation parameters, and homocysteine, have been suggested to correlate with the incidence and prognosis of sudden sensorineural hearing loss (SSNHL). However, the nature of these associations remains controversial.
Feng‐Xin Yang, Yu‐Wan Song, Yan Wang, Kun Zhao, Hu‐Hui‐Fen He, Jing‐Jing Qiu, Da‐Wei Liu, Bo Li, Yan Sun   +8 more
wiley   +1 more source

Multi-Omics Dissection of the Shared Genetic Architecture Between Sleep Traits and Epilepsy. [PDF]

Biology (Basel)
Wang T, Li J, Chen D, Liu Y, Fang C, Wang X, Song Z, Guo M, Wang Y, Naumovski N, Zheng X.   +10 more
europepmc   +1 more source

The Sociogenomics of Social Stratification and General Theories of Inequality

The British Journal of Sociology, EarlyView.
ABSTRACT The field of the sociogenomics of inequalities would benefit from discussing what its findings and ambitions mean for core theories of social stratification and mobility. Do sociologists need to reconsider their critique to structural‐functionalist theory of stratification, and its neo‐classical economic allies, that emphasise efficient ...
Herman G. van de Werfhorst
wiley   +1 more source