Results 141 to 150 of about 174,316 (315)

CRC GWAS data

, 2016
We performed a genome-wide association studies (GWAS) and replicated the findings in seven independent samples from China. In the GWAS stage, 2,364 samples were enrolled from the Cancer Center of Nanjing Medical University.
Zhao, Jian, Hu, Zhibin, Jiachun Lu (129922), Meilin Wang (119128), Dongying Gu (337113), Mulong Du (398711), Jianfeng Xu (80211), Miao, Xiaoping, Zhibin Hu (102783), Shen, Hongbing, Pan, Lei, Lei Yang (102719), Jian Zhao (219525), Xu, Jianfeng, Chen, Jinfei, Zhengdong Zhang (48217), Gu, Dongying, Tang, Cuiju, Zhi Xu (270587), Suzhan Zhang (533746), Zhang, Suzhan, Sun, Jielin, Du, Jiangbo, Jiangbo Du (799656), Jielin Sun (123338), Jinliang Xing (125690), Du, Mulong, Jinfei Chen (222979), Wang, Meilin, Zhu, Lingjun, Lei Pan (191007), Cuiju Tang (451330), Na Tong (123650), Xu, Zhi, Chu, Haiyan, Tong, Na, Xing, Jinliang, Zhang, Zhengdong, Yang, Lei, Lingjun Zhu (392943), Du, Haina, Xiaoping Miao (172046), Haiyan Chu (123641), Rui Zhang (13940), Zhang, Rui, Haina Du (558777), Hongbing Shen (102791), Lu, Jiachun   +47 more
core   +1 more source

Uncovering Coenzyme Q10‐Related Genetic Determinants of Statin‐Associated Muscle Symptoms: Evidence from the UK Biobank and the All of Us Research Program

Clinical Pharmacology &Therapeutics, EarlyView.
Statin‐associated muscle symptoms (SAMS) are frequent adverse effects of statin therapy and have been hypothesized to result from impaired coenzyme Q10 (CoQ10) biosynthesis. Although genetic determinants of CoQ10 levels have been reported, genome‐wide association studies (GWASs) conducted specifically in statin users are lacking. Moreover, direct CoQ10
Da Hoon Lee, Yoon‐A Park, Yubin Song, Ji‐Min Han, Kyung Hee Choi, Myeong Gyu Kim, Hye Sun Gwak   +6 more
wiley   +1 more source

Does Next Generation Sequencing (NGS)‐Based CYP2D6 Sequencing Improve Genotype–Phenotype Concordance in Tamoxifen‐Treated Patients?

Clinical Pharmacology &Therapeutics, EarlyView.
CYP2D6 metabolizes about 20% of commonly used drugs, including tamoxifen, a major hormone therapy for breast cancer. Although the relationship between tamoxifen pharmacokinetics and CYP2D6 genotype has been demonstrated, residual variability in drug exposure remains unexplained.
Jeanne Petit, Julien Plenecassagnes, Aurelie Brice, Florence Dalenc, Ludovic Mallet, Etienne Chatelut, Ayman Al Saati, Fabienne Thomas   +7 more
wiley   +1 more source

Number of genome-wide significant loci for GWAS and GxE GWAS.

, 2019
Shared describes the number of loci that are significant in both the GWAS and GxE GWAS for the same trait (r2 < .2), while GWAS and GxE GWAS describe the loci unique to that association scan. No loci were found for CHD, insulin, or WHR.
Andy Dahl (6560570), Arthur Ko (614124), Na Cai (789644), Jonathan Flint (27822), Markku Laakso (197777), Päivi Pajukanta (62537), Noah Zaitlen (120787)   +6 more
core   +1 more source

GWAS [PDF]

Current Biology, 2013
openaire   +2 more sources

GWAS Matrix

, 2021
GWAS Matrix: Contain all the GWAS results with the input phenotype (coordinates of pseudo-SNPs) and all the GWAS SNPs p-value detected.
openaire   +2 more sources

The Language of Greenwashing: SDG Omission and Opportunity‐Oriented Environmental Tone as Alert Metrics in Green Bond Disclosures

Corporate Social Responsibility and Environmental Management, EarlyView.
ABSTRACT Green bonds play a central role in sustainable finance, yet concerns about greenwashing raise questions about the credibility of issuers' sustainability disclosures. Using dictionary‐based methods and domain‐specific BERT transformer models, this paper proposes two greenwashing alert metrics and investigates their performance by analyzing ...
Andrea Nicolodi, Sandra Paterlini, Monica Gentile, Vincenzo Foglia Manzillo, Gianluca Vittorioso   +4 more
wiley   +1 more source

Estudios de asociación mediante rastreo genómico y su contribución en la genética del asma

Salud Uninorte, 2010
A pesar de todos los esfuerzos realizados por más de una década, las bases genéticas de muchas enfermedades comunes y complejas aún siguen siendo desconocidas, sin desmeritar los notables avances que se han logrado con los estudios de ligamiento en ...
Yosed Anaya Chávez, Beatriz Martínez
doaj  

GWAS-Identified Loci are Associated with Obesity and Type 2 Diabetes Mellitus in Patients with Severe COVID-19

Frontiers in Bioscience-Scholar
Background: Comorbidities such as obesity and type 2 diabetes mellitus (T2DM) have emerged as critical risk factors exacerbating the severity and mortality of COVID-19.
Alexey Loktionov, Ksenia Kobzeva, Anna Dorofeeva, Vera Sergeeva, Olga Bushueva   +4 more
doaj   +1 more source

The role of Rho GTPases in facial morphogenesis

Developmental Dynamics, EarlyView.
The role of small GTPases, RHOA, RAC1, and CDC42 and pathway mediators is reviewed in the context of embryonic facial development. Lip fusion requires cytoskeletal remodeling during morphogenesis of the facial processes and during lip fusion. Fnm, frontonasal mass; lnp, lateral nasal process; mnp, medial nasal process; mxp, maxillary process; np, nasal
Isra Ibrahim, Joy M. Richman
wiley   +1 more source