Results 221 to 230 of about 244,292 (300)

Mendelian Randomization Analysis of the Causal Link Between Rheumatoid Arthritis and Interstitial Lung Disease

Respirology, EarlyView.
This Mendelian randomization study provides genetic evidence supporting a causal effect of rheumatoid arthritis on the risk of interstitial lung disease, highlighting potential shared mechanisms between autoimmune arthritis and pulmonary fibrosis. ABSTRACT Background and Objectives Rheumatoid arthritis (RA) is a systemic autoimmune disease that is ...
Mengyu Zhang, Xiao Chen, Wenqing Zhang, Guang Yang, Yunhong Yin, Yiqing Qu   +5 more
wiley   +1 more source

The genetic architecture of brainstem structures. [PDF]

Nat Commun
Xue H, Fu J, Geng Z, Cheng J, Wang M, Zhang L, Cui G, Yu Y, Liao W, Zhang H, Gao B, Xu X, Han T, Yao Z, Zhang Q, Qin W, Liu F, Liang M, Wang S, Xu Q, Xu J, Wang C, Liu N, Ji Y, Zhang P, Li W, Wei W, Shi D, Lui S, Yan Z, Chen F, Zhang J, Shen W, Miao Y, Wang D, Gao JH, Yang Y, Xu K, Xian J, Zhang B, Zhang X, Zuo XN, Li MJ, Ye Z, Qiu S, Zhu W, Yu C, CHIMGEN Consortium.   +47 more
europepmc   +1 more source

Identification of genetically predicted protein biomarkers and drug targets for prostate cancer via Mendelian randomization

VIEW, EarlyView.
Prostate cancer, a leading cause of cancer in men globally, urgently requires improved diagnostic and treatment strategies. This study analyzed large genetic datasets and identified five key proteins (THBD, DST, IFI27L2, OSBPL10, PPP1R14A) that either increase or decrease cancer risk, while also exploring their roles in immune response and potential ...
Maoping Cai, Tianming Peng, Zhiyue Xie, Chuqian Zhen, Chen Yao, Nan Peng, Qianyi Li, Yuzhong Yu, Jiming Bao, Xian‐Lu Song, Mingkun Chen, Shan‐Chao Zhao   +11 more
wiley   +1 more source

Protocol: Estimating cross-ancestry local genetic correlation using Logica. [PDF]

STAR Protoc
Gao B, Li Z, Zhou X.
europepmc   +1 more source

Integrative Analysis of Plasma Proteome and Genome Reveals Novel Drug Targets for Chronic Rhinosinusitis and Nasal Polyps

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Background Chronic rhinosinusitis (CRS) and nasal polyps (NP) are chronic inflammatory conditions with unsatisfactory treatment outcomes due to frequent recurrence of refractory disease. Identifying new therapeutic targets is essential. Methods We conducted a proteome‐wide Mendelian randomization (MR) analysis by integrating genome‐wide ...
En Zhou, Shi Luo, Yu Xiao, Bin Liu, Xu‐Ping Xiao   +4 more
wiley   +1 more source

DisCP-Atlas: a comprehensive resource mapping cellular processes to complex diseases. [PDF]

Nucleic Acids Res
Wang FQ, Zhang C, Zhang H, Dang X, Sun Y, Bu S, Wang X, Yang W, Cao C.   +8 more
europepmc   +1 more source

Sex Hormones and the Risk of Nasal Polyps: A Two‐Sample Mendelian Randomization Study

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Objective The pathophysiological roles of sex hormones in airway inflammation have drawn much attention recently. We aimed to explore the causal effect of sex hormones on chronic rhinosinusitis (CRS) and nasal polyps (NP) via a Mendelian randomization (MR) study.
Ying Zhu, Jia‐Yao Zhou, Shi‐Yao Zhang, Ru Tang, Chun‐Yu Luo, Yue‐Long Gu, Zhi‐Peng Li, Wei‐Tian Zhang   +7 more
wiley   +1 more source

Transformer-based deep learning enhances discovery in migraine GWAS. [PDF]

Nat Commun
Meng Z, Song Y, Jiang Y, Wang X, Zou Y, Li X, Hakonarson H, Chang X.   +7 more
europepmc   +1 more source

Pathogenesis of Vitiligo: Integrating Immune and Non‐Immune Cell Crosstalk

The Journal of Dermatology, EarlyView.
ABSTRACT Vitiligo is an acquired autoimmune disease characterized by depigmented macules resulting from melanocyte loss. It is a complex multifactorial disorder in which genetic predisposition is combined with environmental factors; however, its detailed etiology remains unclear.
Shintaro Inoue
wiley   +1 more source

Improving accuracy in genome-wide association studies: a two-step approach for handling below limit of detection biomarker measurements. [PDF]

NAR Genom Bioinform
Deng YA, Karlsson T, Johansson Å.
europepmc   +1 more source