Trans-ethnic kidney function association study reveals putative causal genes and effects on kidney-specific disease aetiologies [PDF]
, 2019 Heath, Andrew C. +3 more
core +1 more source
Identification and GWAS analysis of significant genomic loci associated with mastitis resistance in Ayrshire cows [PDF]
Marina V. Pozovnikova +3 more
openalex +1 more source
Advances in the genetics of refractive errors: Contributions from the CREAM consortium
Acta Ophthalmologica, EarlyView.Abstract The Consortium for Refractive Error and Myopia (CREAM) was established in 2011, bringing together an international team of researchers studying more than 30 cohorts. Since its establishment, CREAM has played a pivotal role in research investigating the genetics of myopia and other refractive errors, serving as a key driver of progress in the ...
Sze Wai Rosa Li +11 more
wiley +1 more source
Beyond Single Variants: A Pathway-Based Approach to Explore the Genetic Basis of Memory. [PDF]
Mol Neurobiolvan Beek D +5 more
europepmc +1 more source
Asia Pacific Viewpoint, EarlyView.ABSTRACT This study examines how outsourcing household care in modern South Korea has shaped gendered migration from both rural areas and abroad. To clarify the interplay between macro‐level power and individual lives—an aspect often treated piecemeal in earlier research—it introduces the concept of circular carescapes. This notion captures the looping
Junyoung Park, HaeRan Shin
wiley +1 more source
Lifestyle behaviors, serum metabolites and high myopia: Mendelian randomization and mediation analysis. [PDF]
Int J OphthalmolLiu NE, Xu XT, Yu XB.
europepmc +1 more source
Psychedelics, entactogens and psychoplastogens for depression and related disorders
British Journal of Pharmacology, EarlyView.Currently, the most actively investigated rapidly acting antidepressants, anxiolytics and/or anti PTSD agents, include psychedelics e.g. psilocybin, LSD, N,N‐dimethyltryptamine, ayahuasca; non‐hallucinogenic entactogens, e.g. MDMA; psychoplastogens which rapidly promote neuroplasticity, e.g.
Daniel Hoyer
wiley +1 more source
Fine-mapping a genome-wide meta-analysis of 98,374 migraine cases identifies 181 sets of candidate causal variants. [PDF]
Nat CommunHautakangas H +5 more
europepmc +1 more source
British Journal of Pharmacology, EarlyView.Addressing complexity in the study of life sciences through Systems Biology and Systems Medicine has been transformative, making Systems Pharmacology the next logical step. In this review, we focus on physical stimuli, whose potential in pharmacology has been neglected, despite demonstrated therapeutic properties.
Veronica Paparozzi +10 more
wiley +1 more source
PDE4D and PDE3B orchestrate distinct cAMP microdomains in 3T3‐L1 adipocytes
British Journal of Pharmacology, EarlyView.Basal conditions: •Ins/PDE3B lowers cytoplasmic cAMP (cyt‐cAMP) without affecting plasma membrane cAMP (pm‐cAMP). •Insulin decreases lipid droplet cAMP (LD‐cAMP) independent of PDE3B. •FGF1/PDE4D modestly reduces both cyt‐ and pm‐cAMP, while PDE4D alone can modulate LD‐cAMP. ISO stimulation: •Ins/PDE3B has minimal impact on cyt‐cAMP.
Johannes Krier +9 more
wiley +1 more source