Results 261 to 270 of about 244,292 (300)

HaploVar: An R package for defining local haplotype variants for trait association and trait prediction analyses. [PDF]

Bioinformatics
MacNish TR, Al-Mamun HA, Bergmann T, Bestry MS, Marsh JI, Edwards D.   +5 more
europepmc   +1 more source

Epigenetic mechanisms and therapeutic innovations in chronic pain‐associated neuropsychiatric co‐morbidities

British Journal of Pharmacology, EarlyView.
Abstract Chronic pain, marked by nociceptive sensitization and maladaptive neuroplasticity, affects 30% of the global population with escalating socioeconomic burdens. Epidemiological data show a 2‐3‐fold increase in neuropsychiatric co‐morbidities among individuals with chronic pain, where epigenetic dysregulation serves as a key mechanism linking ...
Kai Zhang, Sijia Zhu, Na Xing, Zhen Zhou, Jiayi Chen, Tianen Si, Mingrui Li, Lin Jia, Yousef Rastegar‐Kashkooli, Tom J. Wang, Wei Zhu, Jing Li, Chao Jiang, Junmin Wang, Moxin Wu, Xiaoping Yin, Weidong Zang, Jian Wang, Songxue Su   +18 more
wiley   +1 more source

TWAS atlas 2.0: an updated data resource for transcriptome-wide association studies. [PDF]

Nucleic Acids Res
Gao H, Bu C, Zheng S, Mai J, Wang J, Tang R, Fan Z, Zeng J, Li J, Xiao J.   +9 more
europepmc   +1 more source

Identification of potential therapeutic targets for stroke and its subtypes by integrating proteomes and genetics from human plasma. [PDF]

Brain Commun
Liu H, Zhang X, Ma H, Nguyen TN, Ling Y, Mo S, Huang Q, Liu J, Zhou Y, Yang P.   +9 more
europepmc   +1 more source

Cardiometabolic Risk in First Degree Relatives of Women With Polycystic Ovary Syndrome (PCOS)

Clinical Endocrinology, EarlyView.
ABSTRACT Objective Polycystic ovary syndrome (PCOS) is a common multisystem disorder with reproductive, cardiometabolic and psychological implications. Genetic factors play a role in the pathogenesis of PCOS. We sought to investigate the cardiometabolic health of first degree relatives (FDR) of women with PCOS.
Su Jen Chua, Xinyi Wu, Tahani Al Kindi, Bulent O. Yildiz, Aya Mousa, Loyal Pattuwage, Helena Teede, Anju E. Joham, Chau Thien Tay   +8 more
wiley   +1 more source

Disentangling the relationship between glucose, insulin and brain health: A UK Biobank study

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Background Glycaemic traits are associated with poorer brain health and dementia risk. Recent advances in genetic instruments for specific glycaemic markers enable an in‐depth investigation of the likely nature of associations and underlying mechanisms between diabetes‐related mechanisms and brain health and dementia.
Andrew C. Mason, Nasri Fatih, Reecha Sofat, Christopher T. Rentsch, Liam Smeeth, Krishnan Bhaskaran, Nish Chaturvedi, Victoria Garfield   +7 more
wiley   +1 more source

Cross-ancestry information transfer framework improves protein abundance prediction and protein-trait association identification. [PDF]

Brief Bioinform
Zhai W, Sun L, Fang W, Dong Y, Cheng C, Liu Y, Zhou Y, Ji J, Wu L, Pan A, Gamazon ER, Pan XF, Zhou D.   +12 more
europepmc   +1 more source

Individualism and working from home

Economic Inquiry, EarlyView.
Abstract We show that culturally transmitted individualism is an important determinant of working from home (WFH). Using individual‐level data from the U.S. Current Population Survey (CPS) and the European Social Survey (ESS), we compare immigrants and their descendants from different cultural backgrounds residing in the same location.
Jan Bietenbeck, Natalie Irmert, Therese Nilsson   +2 more
wiley   +1 more source

Multi-Genome-Wide association studies provide new insights into the genetic architecture of Varroa resistance in honeybees. [PDF]

BMC Genomics
Davoodi P, Razmkabir M.
europepmc   +1 more source

Clinical and genetic landscape of epilepsies with absence seizures and single‐gene etiology

Epilepsia, EarlyView.
Abstract Objective To characterize the clinical, electroencephalographic, and genetic features of epilepsies featuring absence seizures within monogenic etiology, highlighting the diagnostic, treatment and prognostic implications. Methods We conducted a retrospective, multicenter study including patients with monogenic epilepsies and ...
Simona Balestrini, Ilaria Galli, Maria Luisa Ricci, Elena Parrini, Davide Mei, Mario Mastrangelo, Francesco Pisani, Corinna Filippi, Lucio Giordano, Elisabetta Cesaroni, Carla Marini, Emanuele Cerulli Irelli, Carlo di Bonaventura, Marica Rubino, Antonietta Coppola, Jacopo Proietti, Tommaso Lo Barco, Francesca Darra, Laura Licchetta, Francesca Bisulli, Marco Perulli, Domenica Battaglia, Angela De Dominicis, Marina Trivisano, Nicola Specchio, Roberta Solazzi, Davide Caputo, Laura Canafoglia, LICE Collaborative group, Carmen Barba, Emanuele Bartolini, Pia Bernardo, Maria Paola Canevini, Gaetano Cantalupo, Susanna Casellato, Mara Cavallin, Ilaria Contaldo, Alessandro Ferretti, Maria Luigia Gambardella, Tiziana Granata, Giuliana Lentini, Anna Luchetti, Federico Melani, Pasquale Parisi, Simona Pellacani, Laura Pietrangelo, Tiziana Pisano, Ilaria Onida, Emilia Ricci, Aglaia Vignoli, Renzo Guerrini   +50 more
wiley   +1 more source