Results 81 to 90 of about 13,532,360 (331)

Destruxin E Decreases Beta-Amyloid Generation by Reducing Colocalization of Beta-Amyloid-Cleaving Enzyme 1 and Beta-Amyloid Protein Precursor [PDF]

, 2009
Alzheimer-disease-associated beta-amyloid (A beta) is produced by sequential endoproteolysis of beta-amyloid protein precursor (beta APP): the extracellular portion is shed by cleavage in the juxtamembrane region by beta-amyloid-cleaving enzyme (BACE ...
Dohi, Keiji, Fukumori, Akio, Haass, Christian, Hasegawa, Hiroshi, Hosono, Motoko, Itoh, Naohiro, Jiang, Jingwei, Kato, Akira, Katoh, Takaaki, Kikuchi, Jyunko, Kudo, Takashi, Minagawa, Kazuyuki, Mori, Kohji, Morihara, Takashi, Nakano, Yuko, Nakayama, Taisuke, Nishigaki, Atsuko, Nishimura, Masaki, Nishitomi, Kouhei, Okochi, Masayasu, Sakaguchi, Gaku, Tagami, Shinji, Takeda, Masatoshi, Takemoto, Hiroshi, Takinami, Yoshihiko, Tanaka, Toshihisa, Willem, Michael, Yanagida, Kanta   +27 more
core   +1 more source

Changes in Body Composition in Children and Young People Undergoing Treatment for Acute Lymphoblastic Leukemia: A Systematic Review and Meta‐Analysis

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Ongoing evidence indicates increased risk of sarcopenic obesity among children and young people (CYP) with acute lymphoblastic leukemia (ALL), often beginning early in treatment, persisting into survivorship. This review evaluates current literature on body composition in CYP with ALL during and after treatment.
Lina A. Zahed, Raquel Revuelta Iniesta, Mary Fewtrell, Julie Lanigan, Breeana Gardiner, Graeme O'Connor   +5 more
wiley   +1 more source

Drug Repositioning of Proton Pump Inhibitors for Enhanced Efficacy and Safety of Cancer Chemotherapy

Frontiers in Pharmacology, 2017
Proton pump inhibitors (PPIs), H+/K+-ATPase inhibitors, are the most commonly prescribed drugs for the treatment of gastroesophageal reflux and peptic ulcer diseases; they are highly safe and tolerable.
Kenji Ikemura, Kenji Ikemura, Shunichi Hiramatsu, Masahiro Okuda, Masahiro Okuda   +4 more
doaj   +1 more source

Activation of GRP78 ATPase suppresses A549 lung cancer cell migration by promoting ITGB4 degradation

Cell Adhesion & Migration, 2022
Hypochlorous acid (HOCl) is an essential signal molecule in cancer cells. Activated GRP78 ATPase by a HOCl probe named ZBM-H inhibits lung cancer cell growth.
Junya Ning, Xiaoling Cui, Nan Li, Na Li, Baoxiang Zhao, Junying Miao, Zhaomin Lin   +6 more
doaj   +1 more source

Localization of H + -ATPases in soybean root nodules

Planta, 1999
The localization of H(+)-ATPases in soybean (Glycine max L. cv. Stevens) nodules was investigated using antibodies against both P-type and V-type enzymes. Immunoblots of peribacteroid membrane (PBM) proteins using antibodies against tobacco and Arabidopsis H(+)-ATPases detected a single immunoreactive band at approximately 100 kDa.
Fedorova, E, Thomson, Rowena, Whitehead, Lynne, Maudoux, O, Udvardi, Michael K, Day, David A   +5 more
openaire   +4 more sources

Role of CFTR and ClC-5 in Modulating Vacuolar H+-ATPase Activity in Kidney Proximal Tubule [PDF]

, 2010
Background/Aims: It has been widely accepted that chloride ions moving along chloride channels act to dissipate the electrical gradient established by the electrogenic transport of H+ ions performed by H+-ATPase into subcellular vesicles.
Bezerra, Camila N. A., Carraro-Lacroix, Luciene Regina, Girardi, Adriana C. C., Lessa, Lucilia M. A., Malnic, Gerhard, Morales, Marcelo M., Pessoa, Thaissa D., Souza-Menezes, Jackson   +7 more
core   +1 more source

Parent‐to‐Child Information Disclosure in Pediatric Oncology

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Despite professional consensus regarding the importance of open communication with pediatric cancer patients about their disease, actual practice patterns of disclosure are understudied. Extant literature suggests a significant proportion of children are not told about their diagnosis/prognosis, which is purported to negatively ...
Rachel A. Kentor, Flora Hoodin, Michelle Byrd, Kristin A. Kullgren, Leah LaLonde, Lauren Benkoske, Patrick Smith, Dawn Carson, Karen MacDonald, Susumu Inoue, Brenda Kitchen, Kate Gowans, Gregory A. Yanik   +12 more
wiley   +1 more source

Radiotherapy Delivery in Deep Inspiration for Pediatric Patients—Final Results of the Phase II Feasibility Study TEDDI

Pediatric Blood &Cancer, EarlyView.
Abstract Introduction The TEDDI trial tested the feasibility and reproducibility of deep‐inspiration breath‐hold (DIBH) in pediatric patients referred for radiotherapy. This report presents final results, including patient‐reported outcomes (PRO) and dosimetric comparison of DIBH and free‐breathing (FB).
Daniella Elisabet Østergaard, Anni Young Lundgaard, Laura Ann Rechner, Danijela Dejanovic, Hanne Krogh Rose, Jolanta Hansen, Leila Vaalavirta, Miia Mokka, Marianne Aznar, Peder Skov Wehner, Lisa Lyngsie Hjalgrim, Maja Vestmø Maraldo   +11 more
wiley   +1 more source

MAPPING AND CHARACTERIZATION OF THE VACUOLAR H+-ATPASE (V-H-ATPASE) SUBUNIT IN THE MOUSE. † 2202 [PDF]

Pediatric Research, 1996
MAPPING AND CHARACTERIZATION OF THE VACUOLAR H + -ATPASE (V-H-ATPASE) SUBUNIT IN THE MOUSE ...
Ari M Simckes, Steven A Giambrone, Lisa L Dowler, Robert A White   +3 more
openaire   +1 more source

A mouse model of autism implicates endosome pH in the regulation of presynaptic calcium entry. [PDF]

, 2018
Psychoactive compounds such as chloroquine and amphetamine act by dissipating the pH gradient across intracellular membranes, but the physiological mechanisms that normally regulate organelle pH remain poorly understood.
Bendor, Jacob, Edwards, Robert H, Levy, Jonathan, Nicoll, Roger A, Pham, Ellen, Seifikar, Helia, Silm, Katlin, Sohal, Vikaas S, Sullivan, Michael, Ullman, Julie C, Yang, Jing   +10 more
core   +3 more sources