Results 11 to 20 of about 2,153 (117)

Validation of a method evaluating T cell metabolic potential in compliance with ICH Q2 (R1)

Journal of Translational Medicine, 2021
Background Metabolic cell features are able to give reliable information on cell functional state. Thus, metabolic potential assessment of T cells in malignancy setting represents a promising area, especially in adoptive cell therapy procedures.
Patricia Mercier-Letondal, Chrystel Marton, Yann Godet, Jeanne Galaine   +3 more
doaj   +1 more source

Effets résiduels d’un antiparasitiaire, le benzoate de benzyle testé sur Glossina p.palpalis Robineau Desvoidy (Diptera : Glossinidae)

Revue d’Elevage et de Médecine Vétérinaire des Pays Tropicaux, 1994
Les effets d'un antiparasitaire, le benzoate de benzyle (BP), ont été évalués en laboratoire sur la survie et les performances de reproduction de Glossina p.
A.B. Ahmed, J.A. Onyiah
doaj   +1 more source

Pro-Resolving Factor Administration Limits Cancer Progression by Enhancing Immune Response Against Cancer Cells

Frontiers in Immunology, 2022
Cancers are consequences of cellular dysfunction leading to an aberrant cellular multiplication and proliferation, subsequently yielding metastasis formation.
Audrey Wetzel, Audrey Wetzel, Francis Bonnefoy, Francis Bonnefoy, Cécile Chagué, Mathieu Vetter, Mélanie Couturier, Blandine Baffert, Olivier Adotévi, Olivier Adotévi, Philippe Saas, Sylvain Perruche, Sylvain Perruche   +12 more
doaj   +1 more source

CRISPR/Cas9 Genome Editing Reveals That the Intron Is Not Essential for var2csa Gene Activation or Silencing in Plasmodium falciparum

mBio, 2017
Plasmodium falciparum relies on monoallelic expression of 1 of 60 var virulence genes for antigenic variation and host immune evasion. Each var gene contains a conserved intron which has been implicated in previous studies in both activation and ...
Jessica M. Bryant, Clément Regnault, Christine Scheidig-Benatar, Sebastian Baumgarten, Julien Guizetti, Artur Scherf   +5 more
doaj   +1 more source

Description de Tunga bonneti n. sp. du Chili (Siphonaptera : Tungidae) et notes sur sa spécificité, sa chorologie, son dermecos et sa phénologie

Parasite, 2012
Tunga libis a été à tort signalée du Chili par Smit (1968). Il s’agit en fait d’une espèce nouvelle, relativement peu rare, que nous décrivons ici. Non seulement les individus libres sont connus dans les deux sexes, mais également les femelles enkystées ...
Beaucournu J.-C., Mergey T., Muñoz-Leal S., González-Acuña D.   +3 more
doaj   +1 more source

Humanized mice for investigating sustained Plasmodium vivax blood-stage infections and transmission

Nature Communications, 2022
Plasmodium vivax is the most widespread human malaria parasite but due to its tropism for immature red blood cells in vitro culturing and studies are difficult. Here, LuizaBatista et al.
Camilla Luiza-Batista, Sabine Thiberge, Malika Serra-Hassoun, Flore Nardella, Aurélie Claës, Vanessa C. Nicolete, Pierre-Henri Commère, Liliana Mancio-Silva, Marcelo U. Ferreira, Artur Scherf, Sylvie Garcia   +10 more
doaj   +1 more source

Investigation of the prognostic value of CD4 T cell subsets expanded from tumor-infiltrating lymphocytes of colorectal cancer liver metastases

Journal for ImmunoTherapy of Cancer, 2020
Background The positive role of CD8+ tumor-infiltrating lymphocytes (TIL) in patients with colorectal cancer (CRC) has been well described but the prognostic value of CD4 T cell subsets remained to be investigated.
Olivier Adotevi, Marie Kroemer, Celia Turco, Laurie Spehner, Julien Viot, Idir Idirène, Adeline Bouard, Elodie Renaude, Marina Deschamps, Yann Godet, Samuel Limat, Bruno Heyd, Marine Jary, Romain Loyon, Christophe Borg   +14 more
doaj   +1 more source

The ATG8 Family Proteins GABARAP and GABARAPL1 Target Antigen to Dendritic Cells to Prime CD4⁺ and CD8⁺ T Cells

Cells, 2022
Vaccine therapy is a promising method of research to promote T cell immune response and to develop novel antitumor immunotherapy protocols. Accumulating evidence has shown that autophagy is involved in antigen processing and presentation to T cells.
Leïla Fonderflick, Timothée Baudu, Olivier Adotévi, Michaël Guittaut, Pascale Adami, Régis Delage-Mourroux   +5 more
doaj   +1 more source

Resolution therapy: Harnessing efferocytic macrophages to trigger the resolution of inflammation

Frontiers in Immunology, 2022
Several chronic inflammatory diseases are associated with non-resolving inflammation. Conventional anti-inflammatory drugs fail to completely cure these diseases.
Philippe Saas, Mathieu Vetter, Melissa Maraux, Francis Bonnefoy, Francis Bonnefoy, Sylvain Perruche, Sylvain Perruche   +6 more
doaj   +1 more source

PD-L1 expression is regulated by both DNA methylation and NF-kB during EMT signaling in non-small cell lung carcinoma

OncoImmunology, 2018
Tumor cells, which undergo Epithelial-mesenchymal transition (EMT) acquire increased capacities of proliferation, invasion and have the ability to generate metastases by escaping the immune system during their systemic migration.
A. Asgarova, K. Asgarov, Y. Godet, P. Peixoto, A. Nadaradjane, M. Boyer-Guittaut, J. Galaine, D. Guenat, V. Mougey, J. Perrard, J. R. Pallandre, A. Bouard, J. Balland, C. Tirole, O. Adotevi, E. Hendrick, M. Herfs, P. F. Cartron, C. Borg, E. Hervouet   +19 more
doaj   +1 more source