Results 61 to 70 of about 33,614,495 (309)
Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig +10 morewiley +1 more sourceUtilization of Staphylococcal Immune Evasion Protein Sbi as a Novel Vaccine Adjuvant
Frontiers in Immunology, 2019 Co-ligation of the B cell antigen receptor with complement receptor 2 on B-cells via a C3d-opsonised antigen complex significantly lowers the threshold required for B cell activation.Yi Yang, Catherine R. Back, Melissa A. Gräwert, Ayla A. Wahid, Harriet Denton, Rebecca Kildani, Joshua Paulin, Kristin Wörner, Wolgang Kaiser, Dmitri I. Svergun, Asel Sartbaeva, Andrew G. Watts, Kevin J. Marchbank, Jean M. H. van den Elsen +13 moredoaj +1 more sourceTranslophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura +11 morewiley +1 more sourcePlasmodium falciparum antigens on the surface of the gametocyte-infected erythrocyte. [PDF]
, 2008 BACKGROUND: The asexual blood stages of the human malaria parasite Plasmodium falciparum produce highly immunogenic polymorphic antigens that are expressed on the surface of the host cell.Christopher J. Drakeley, Saeed Maha, Saeed, Maha, Alexander Neal, Saeed, M., Geoffrey A T Targett, Sutherland, Colin J, Drakeley Christopher J., Targett Geoffrey A. T., Roeffen Will, Geoffrey A. T. Targett, Colin J. Sutherland, Targett, Geoffrey AT, Alexander, N., Neal Alexander, Colin J Sutherland, Sutherland Colin J., Targett, G.A.T., Roeffen, W.F.G., Roeffen, Will, Maha Saeed, Alexander, Neal, Drakeley, Christopher J, Drakeley, C., Will Roeffen, Christopher J Drakeley, Sutherland, C.J. +26 morecore +2 more sourcesKDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan +16 morewiley +1 more sourceImmunogenetic and immunochemical studies of H-2 antigens of foreign haplotypes on tumour cells
, 1979 The polymorphism of histocompatibility antigens is usually explained by classical Mendelian laws, which allow the inheritance of one allele per locus.Festenstein, H, Matossian, rogers, A. Matossian Rogers, G. Atfield, Morelli, O, Atfield, G, C. Testorelli, W. Schmidt, Schmidt, W, O. Marelli, H. Festenstein, L. De Giorgi, Testorelli, C, Giorgi, L D +13 morecore +1 more sourceTranscriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel +14 morewiley +1 more sourceAnalysis of host responses to Mycobacterium tuberculosis antigens in a multi-site study of subjects with different TB and HIV infection states in sub-Saharan Africa. [PDF]
, 2013 BACKGROUND: Tuberculosis (TB) remains a global health threat with 9 million new cases and 1.4 million deaths per year. In order to develop a protective vaccine, we need to define the antigens expressed by Mycobacterium tuberculosis (Mtb), which are ...Kaufmann, S.H.E., Ambrose, Lyn R., Gomez, M., Martin Ota (198869), Lalor, M., Donkor Simon, Novel N Chegou, Kees Franken, Willem Hanekom (23103), Gerhard Walzl (149313), Mihret, A., Crampin, Amelia C, Simon Donkor (343534), Parida, S., Thiel Bonnie A., Hazel M Dockrell, Hanekom, Willem, GCGH Biomarkers for TB consortium, Amelia C Crampin, Parida, Shreemanta K., Kassa, Desta, Loxton, Andre G., Gomez, M.P., Martin Ota, Crampin, Amelia C., Loxton, Andre G, Rawleigh Howe (456745), Hanekom Willem, Parida Shreemanta K., W. Henry Boom (125099), Simon Donkor, Lalor, Maeve K., Ambrose, Lyn R, Andre G. Loxton (160294), Howe Rawleigh, Dockrell Hazel M., Kassa Desta, Gomez, Marie P., Boom, W. Henry, Sutherland, Jayne S, Franken Kees, Ota, Martin, Stefan H E Kaufmann, GCGH Biomarkers TB Consortium, Stefan H. E. Kaufmann (149315), Walzl, G., Crampin, A.C., Mayanja-Kizza Harriet, Sutherland, Jayne S., Michel R. Klein (160302), Lalor Maeve K., Black, Gillian F, Chegou Novel N., Black, G., Harriet Mayanja-Kizza (78637), Donkor, S., Maeve K Lalor, Gomez Marie P., Boom, W.H., Donkor, Simon, Kassa, D., Loxton, A.G., Kees Franken (456747), Amelia C. Crampin (239427), Ambrose, L.R., Desta Kassa (456743), Crampin, A., Black, Gillian F., Thiel, Bonnie A., Ambrose Lyn R., Dockrell, Hazel M., Lyn R Ambrose, Adane Mihret, Hazel M. Dockrell (255469), Klein Michel R., Parida, Shreemanta K, Franken, K., Dockrell, H.M., Walzl Gerhard, Kaufmann, Stefan H.E., Boom, W Henry, Shreemanta K. Parida (149299), Klein, Michel R., Chegou, Novel N, Klein, M.R., Bonnie A Thiel, Lyn R. Ambrose (456742), Ota Martin, Thiel, B.A., Andre G Loxton, Sutherland, J., Shreemanta K Parida, Harriet Mayanja-Kizza, Ottenhoff Tom H. M., Ota, M., Loxton, A., Howe, R., Mayanja-Kizza, H., Ottenhoff, Tom HM, Tom H M Ottenhoff, Cardona, Pere-Joan, Ottenhoff, T.H.M., Willem Hanekom, Crampin Amelia C., Gomez, Marie P, Novel N. Chegou (160288), Chegou, Novel N., Klein, M., Sutherland, J.S., Lalor, M.K., Thiel, Bonnie A, Bonnie A. Thiel (456748), Maeve K. Lalor (356874), Ottenhoff, T., Walzl, Gerhard, Gillian F. Black (149301), Boom W. Henry, Ambrose, L., Hanekom, W., Marie P Gomez, Lalor, Maeve K, Adane Mihret (456744), Chegou, N.N., Marie P. Gomez (456746), Jayne S Sutherland, Sutherland Jayne S., Klein, Michel R, Chegou, N., Jayne S. Sutherland (334202), Kaufmann, Stefan HE, Parida, S.K., Mihret Adane, Kaufmann Stefan H. E., Ottenhoff, Tom H.M., W Henry Boom, Rawleigh Howe, Thiel, B., Gerhard Walzl, Tom H. M. Ottenhoff (160303), Gillian F Black, Dockrell, H., Black Gillian F., Howe, Rawleigh, Boom, W., Black, G.F., Loxton Andre G., Desta Kassa, Ottenhoff, Tom H M, Kaufmann, S., Mihret, Adane, Franken, Kees, Mayanja-Kizza, Harriet, Michel R Klein, Kaufmann, Stefan H E, Dockrell, Hazel M +154 morecore +3 more sources
