Results 51 to 60 of about 33,614,495 (309)

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Novel Monoclonal Antibodies 1D2 and 4E4 Against Aspergillus Glycoprotein Antigens Detect Early Invasive Aspergillosis in Mice

Journal of Fungi
Due to the high morbidity and mortality rates of invasive aspergillosis (IA) and the importance of early IA detection for successful treatment and subsequent outcome, this study aimed to determine a time course of detectable antigen in a mouse model of ...
Xihua Lian, Amy Scott-Thomas, John G. Lewis, Madhav Bhatia, Stephen T. Chambers   +4 more
doaj   +1 more source

Desensitization of delayed-type hypersensitivity in mice: suppressive environment

Mediators of Inflammation, 1993
The systemic injection of high doses of antigen into a preimmunized animal results in transient unresponsiveness of cell-mediated immune responses. This phenomenon is known as desensitization.
Takashi Katsura, Kazuo Kobayashi, Michio Hosaka, Sachiko Sugihara, Tsuyoshi Kasama, Keita Kasahara, Stanley Cohen, Takeshi Yoshida   +7 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Vaccinia virus expressing ICP47 : a novel platform for cancer vaccines highlighting tumor epitopes and hiding viral antigens [PDF]

, 2010
Background Recombinant poxviruses expressing tumor associated antigens (TAAs) are evaluated since 20 years as immunogenic vaccine vector in clinical trials.
Raafat, Nermin Abdel Fattah
core   +1 more source

Generation of Polyclonal Antibodies Against Sabin Poliovirus D- and H-Antigens and Their Application in ELISA

Vaccines
Background/Objectives: The World Health Organization (WHO) recommends the use of attenuated Sabin strains for the production of inactivated poliovirus vaccine (IPV), offering improved biosafety while retaining immunogenicity.
Anna Zyrina, Anna Shishova, Irina Tcelykh, Igor Levin, Olga Shmeleva, Nadezhda Borisenko, Maya Ermakova, Sergey Ivanov, Anastasia Kovpak, Vladislav Vasilenko, Yuliya Rogova, Alla Zhitkevich, Nikita Khabibullin, Yury Ivin, Anastasia Piniaeva, Alexandra Siniugina, Aydar Ishmukhametov   +16 more
doaj   +1 more source

MicroRNA-762 is upregulated in human corneal epithelial cells in response to tear fluid and Pseudomonas aeruginosa antigens and negatively regulates the expression of host defense genes encoding RNase7 and ST2. [PDF]

PLoS ONE, 2013
Mucosal surfaces regulate defenses against infection and excessive inflammation. We previously showed that human tears upregulated epithelial expression of genes encoding RNase7 and ST2, which inhibited Pseudomonas aeruginosa invasion of human corneal ...
James Mun, Connie Tam, Gary Chan, Jong Hun Kim, David Evans, Suzanne Fleiszig   +5 more
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Infection with Helicobacter pylori and the age at onset of coeliac disease in the “HUNT4” survey

BMC Research Notes
Objective This study aimed to determine whether H. pylori or its antigens affect the age at which coeliac disease (CeD) was diagnosed. Participants over 20 years old from the HUNT4 survey were screened for CeD by measuring serum immunoglobulin A and ...
Kjetil K. Melby, Rebecka Hjort, Knut E. A. Lundin, Eivind Ness-Jensen   +3 more
doaj   +1 more source

2,4-Dihydroxypentanoic Acids: New Non-sugar Components of Bacterial Polysaccharides

Natural Product Communications, 2008
New components of bacterial polysaccharides, (2 S ,4 R )- and (2 R ,4 R )-2,4-dihydroxypentanoic acids, were identified using two-dimensional 1 H and 13 C NMR spectroscopy in the O-antigens of Providencia alcalifaciens O8 and O31.
Alexander S. Shashkov, Nina A. Kocharova, Filip V. Toukach, Vadim V. Kachala, Yuriy A. Knirel   +4 more
doaj   +1 more source