Results 41 to 50 of about 468,648 (266)

Generation of Polyclonal Antibodies Against Sabin Poliovirus D- and H-Antigens and Their Application in ELISA

Vaccines
Background/Objectives: The World Health Organization (WHO) recommends the use of attenuated Sabin strains for the production of inactivated poliovirus vaccine (IPV), offering improved biosafety while retaining immunogenicity.
Anna Zyrina, Anna Shishova, Irina Tcelykh, Igor Levin, Olga Shmeleva, Nadezhda Borisenko, Maya Ermakova, Sergey Ivanov, Anastasia Kovpak, Vladislav Vasilenko, Yuliya Rogova, Alla Zhitkevich, Nikita Khabibullin, Yury Ivin, Anastasia Piniaeva, Alexandra Siniugina, Aydar Ishmukhametov   +16 more
doaj   +1 more source

MicroRNA-762 is upregulated in human corneal epithelial cells in response to tear fluid and Pseudomonas aeruginosa antigens and negatively regulates the expression of host defense genes encoding RNase7 and ST2. [PDF]

PLoS ONE, 2013
Mucosal surfaces regulate defenses against infection and excessive inflammation. We previously showed that human tears upregulated epithelial expression of genes encoding RNase7 and ST2, which inhibited Pseudomonas aeruginosa invasion of human corneal ...
James Mun, Connie Tam, Gary Chan, Jong Hun Kim, David Evans, Suzanne Fleiszig   +5 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Infection with Helicobacter pylori and the age at onset of coeliac disease in the “HUNT4” survey

BMC Research Notes
Objective This study aimed to determine whether H. pylori or its antigens affect the age at which coeliac disease (CeD) was diagnosed. Participants over 20 years old from the HUNT4 survey were screened for CeD by measuring serum immunoglobulin A and ...
Kjetil K. Melby, Rebecka Hjort, Knut E. A. Lundin, Eivind Ness-Jensen   +3 more
doaj   +1 more source

2,4-Dihydroxypentanoic Acids: New Non-sugar Components of Bacterial Polysaccharides

Natural Product Communications, 2008
New components of bacterial polysaccharides, (2 S ,4 R )- and (2 R ,4 R )-2,4-dihydroxypentanoic acids, were identified using two-dimensional 1 H and 13 C NMR spectroscopy in the O-antigens of Providencia alcalifaciens O8 and O31.
Alexander S. Shashkov, Nina A. Kocharova, Filip V. Toukach, Vadim V. Kachala, Yuriy A. Knirel   +4 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Utilization of Staphylococcal Immune Evasion Protein Sbi as a Novel Vaccine Adjuvant

Frontiers in Immunology, 2019
Co-ligation of the B cell antigen receptor with complement receptor 2 on B-cells via a C3d-opsonised antigen complex significantly lowers the threshold required for B cell activation.
Yi Yang, Catherine R. Back, Melissa A. Gräwert, Ayla A. Wahid, Harriet Denton, Rebecca Kildani, Joshua Paulin, Kristin Wörner, Wolgang Kaiser, Dmitri I. Svergun, Asel Sartbaeva, Andrew G. Watts, Kevin J. Marchbank, Jean M. H. van den Elsen   +13 more
doaj   +1 more source

Investigations of hemadsorption characteristics of glycoprotein HN and F antigen of parainfluenza 3 virus outer membrane in vitro [PDF]

Veterinarski Glasnik, 2006
The objective of our investigations was to examine the hemadsorption characteristics of glycoprotein HN and F antigens of the outer membrane of the parainfluenza 3 virus.
Nišavić Jakov, Milić Nenad
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source