Results 81 to 90 of about 12,744,689 (299)

The Effect of Lane Changing on Long-Span Highway Bridge Traffic Loading [PDF]

, 2012
Bridge Maintenance, Safety, Management, Resilience & Sustainability, Sixth International IABMAS Conference, Stresa, Lake Maggiore, Italy, 8-12 July 2012Maximum loading on long-span bridges typically occurs in congested traffic conditions.
Carey, Colm, B Enright, E OBrien, O\u27Brien, Eugene J., C Carey, O'Brien, Eugene J., Enright, Bernard, C Caprani, Caprani, Colin C.   +8 more
core   +2 more sources

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Bridge and Dementia Study

, 2017
The dataset contains a cross section of over 7000 individuals completing a survey exploring the link between the card game Bridge and quality of life.
McDonnell, Diarmuid, Small, Caroline, Punch, Samantha   +2 more
core   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Analysis of a Novel Four Level Flying Capacitor H – Bridge Converter

International Journal of Renewable Energy Development, 2018
In this paper, a novel four-level flying capacitor inverter and its comparison with the conventional flying capacitor topology in terms of THD analysis are proposed.
Feyzullah Gülpınar, Filiz Sarı, Yunus Uzun   +2 more
doaj   +1 more source

Durability of FRP strengthened reinforced concrete flexural members for bridge structures

, 2016
The use of externally bonded Fibre Reinforced Polymer (FRP) composites has become a popular means to strengthen and repair bridge and building infrastructure in recent years.
Gravina, R., Aydin, H., Hadigheh, S., Visintin, P.   +3 more
core  

Fault-tolerance e tecniche ottimizzate di controllo di convertitori multilivello per applicazioni industriali e di trazione [PDF]

, 2008
Messa a punto di tecniche di controllo e di soluzioni circuitali con robustezza ai guasti per convertitori multilivello in configurazione "cascaded H-bridge" e "diode ...
DANNIER. Adolfo, Dannier, Adolfo
core