Results 81 to 90 of about 362,159 (303)
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Analysis of the power balance In the cells of a multilevel cascaded H-Bridge converter [PDF]
, 2010 Multilevel cascaded H-Bridge converters (CHB) have been presented as a good solution for high power applications. In this way, several control and modulation techniques have been proposed for this power converter topology.
Carrasco Solís, Juan Manuel +7 more
core
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
DC-link voltage balancing in cascaded H-Bridge converters
Archives of Electrical Engineering, 2014 In this paper a DC-link voltage balancing strategy for multilevel Cascaded H-Bridge (CHB) converter is proposed. Presented solution bases on optimal choice of active vector durations in Space-Vector Pulse Width Modulation (SV-PWM).
Lewicki Arkadiusz
doaj +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
A Simple Analysis of the Second (Extra) Disulfide Bridge of VHHs
MoleculesCamelids produce a special type of antibody, known as VHHs, that has lost the VL domain, providing a more optimised VH domain. This particular highly stable antibody domain has interesting properties for biotechnological development.
Carla Martins +4 more
doaj +1 more source
Hybrid, multi-megawatt HVDC transformer topology comparison for future offshore wind farms [PDF]
, 2017 With the wind industry moving further offshore, High Voltage Direct Current (HVDC) transmission is becoming increasingly popular. HVDC transformer substations are not optimized for the offshore industry though, increasing costs and reducing redundancy. A
Abusara, Mohammad +5 more
core +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Compensation techniques for non-linearities in H-bridge inverters
Journal of Electrical Systems and Information Technology, 2016 This paper presents compensation techniques for component non-linearities in H-bridge inverters as those used in grid-connected photovoltaic (PV) inverters.
Daniel Zammit +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source