Results 61 to 70 of about 12,133,437 (297)
FEBS Letters, EarlyView.Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise +5 more
wiley +1 more source
Compensation techniques for non-linearities in H-bridge inverters
Journal of Electrical Systems and Information Technology, 2016 This paper presents compensation techniques for component non-linearities in H-bridge inverters as those used in grid-connected photovoltaic (PV) inverters.
Daniel Zammit +2 more
doaj +1 more source
Smaller is better: nanobodies meet NMR
FEBS Letters, EarlyView.Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley +1 more source
A Simple Analysis of the Second (Extra) Disulfide Bridge of VHHs
MoleculesCamelids produce a special type of antibody, known as VHHs, that has lost the VL domain, providing a more optimised VH domain. This particular highly stable antibody domain has interesting properties for biotechnological development.
Carla Martins +4 more
doaj +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Model Predictive Control of Multilevel Cascaded H-Bridge Inverters
IEEE Transactions on Industrial Electronics, 2010 This paper presents a model predictive current control algorithm that is suitable for multilevel converters and its application to a three-phase cascaded H-bridge inverter. This control method uses a discrete-time model of the system to predict the future value of the current for all voltage vectors, and selects the vector which minimizes a cost ...
Patricio Cortes +4 more
openaire +3 more sources
105 years with the interstate bridge
, 2022 The Interstate Bridge opened on February 14, 1917 amid much fanfare. It cost travelers -- both vehicles and horses! -- five cents to cross the bridge. There were two lanes of traffic, one in each direction, as well as a streetcar.
core
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
An optimal parameter design method for cascaded H‐bridge multi‐level converter in wind farm
IET Renewable Power GenerationThe cascaded H‐bridge multi‐level converter is the main topology of high‐voltage and high‐capacity converter in renewable energy power generation, energy storage system and reactive power compensation equipment.
Huagen Xiao, Yongxi Zhang
doaj +1 more source