Results 41 to 50 of about 9,474,558 (312)

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Design and Hardware Implementation Considerations of Modified Multilevel Cascaded H-Bridge Inverter for Photovoltaic System

IEEE Access, 2019
Inverters are an essential part in many applications including photovoltaic generation. With the increasing penetration of renewable energy sources, the drive for efficient inverters is gaining more and more momentum. In this paper, output power quality,
Shuvangkar Shuvo, Eklas Hossain, Tanveerul Islam, Abir Akib, Sanjeevikumar Padmanaban, Md. Ziaur Rahman Khan   +5 more
doaj   +1 more source

Power Routing for Cascaded H-Bridge Converters [PDF]

IEEE Transactions on Power Electronics, 2017
Modular power converters are expected to play a major role in medium- and high-voltage/power applications. Normally, each module processes the same amount of power; however, this does not take into consideration that different modules can have a different remaining useful lifetime. This paper proposes the concept of power routing for cascaded H-bridge (
Youngjong Ko, Markus Andresen, Giampaolo Buticchi, Marco Liserre   +3 more
openaire   +2 more sources

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Overvoltage Crowbar Protection Based on Passive Power Supplied Control Unit

Power Electronics and Drives
The increase in the involvement of renewable energy sources results in a high rate of semiconductor power converter applications. The power converters provide interconnections of DC microgrids with AC distribution lines.
Strossa Jan, Damec Vladislav, Sobek Martin, Cyprich Pavel, Cyprich Petr, Kubatko Marek   +5 more
doaj   +1 more source

Active power decoupling and controlling for single-phase FACTS device

The Journal of Engineering, 2019
Single-phase FACTS device has a bulky and short-life electrolytic capacitor to absorb the ripple pulsating at twice of the line frequency in DC side, resulting in lower power density. This paper introduced a structure of three-phase bridge which added an
Junmin Zhang, Kaipei Liu, Yan Liu, Shunfan He, Wei Tian   +4 more
doaj   +1 more source

A modified H-bridge multilevel inverter for photovoltaic system

IEICE Electronics Express, 2010
This paper presents a modified H-bridge seven-level single-phase grid-connected inverter for photovoltaic system with a novel pulse-width-modulated (PWM) control scheme. The inverter is capable of producing seven output-voltage levels (V-dc, 2V(dc)/3, V-dc/3, 0, -V-dc, -2V(dc)/3, -V-dc/3) from the dc supply voltage.
Nasrudin Abd. Rahim, Krismadinata Chaniago, Jeyraj Selvaraj   +2 more
openaire   +2 more sources

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Performance of a deep excavation and the influence on adjacent piles: A case history in karst region covered by clay and sand

Underground Space, 2023
This paper presents a case study of deep excavation adjacent to an existing bridge in karst region of Guangzhou city, China. The movements of retaining structures, settlements of surrounding ground and pipelines, and the responses of bridge piles were ...
Yubing Yang, Caiyuan Chen, Chao Liu, Longtian Huang, Wei Chen, Nengyou Lin, Jie Cui, Wandong Xie   +7 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source