Results 101 to 110 of about 19,217,453 (333)

Local and global Fokker-Planck neoclassical calculations showing flow and bootstrap current modification in a pedestal

, 2012
In transport barriers, particularly H-mode edge pedestals, radial scale lengths can become comparable to the ion orbit width, causing neoclassical physics to become radially nonlocal.
Belli E A, Belli E A, Belli E A, Catto P J, Cohen R H, Corre Y, Darin R Ernst, Diallo A, Groebner R J, Hazeltine R D, Helander P, Kagan G, Kagan G, Kagan G, Kernbichler W Kasilov S V Leitold G O Nemov V V Allmaier K, Maggi C F, Maingi R, Marr K D, Matt Landreman, Meyer H, Morgan T W Meyer H Temple D Tallents G J, Pütterich T, Sauter O Lin-Liu Y R Hinton F L Vaclavik J, Sauter P, Snyder P B, Sontag A C, Taguchi M, Wong S K, Xu X Q   +28 more
core   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Density and radiation operational limits to H-mode sustainment

Nuclear Fusion
High confinement, high power and high density operation is likely to face the H-mode density limit (HDL), making it a key issue for magnetically confined fusion.
P. Manz
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Experimental observation and edge characteristics of EDA H-mode on the HL-3 tokamak

Nuclear Fusion
The enhanced ${D_\alpha }$ (EDA) H-mode features high energy confinement together with the absence of edge localized modes (ELMs) and impurity accumulation, making it highly attractive for fusion reactors. The EDA H-mode has been observed recently in the
Anshu Liang, Xiaolan Zou, Wulyu Zhong, Yu Zhou, Guoliang Xiao, Rui Ke, Wenping Guo, Shaobo Gong, Liang Liu, Tengfei Sun, Na Wu, Min Jiang, Yiren Zhu, Shiqin Wang, Guanqun Xue, Xin Yu, Jie Wen, Deliang Yu, Zhongbing Shi, Bo Li, Wei Chen, Xiaoquan Ji   +21 more
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Limiter H-mode experiments on TFTR [PDF]

, 1991
Limiter H-modes with centrally peaked density profiles have been obtained in TFTR using a highly conditioned graphite limiter. The transition to these centrally peaked H-modes takes place from the supershot to the H-mode rather than the usual L- to H-mode transition observed on other tokamaks.
Bush, C. E. (Oak Ridge National Lab., TN (USA)), Bretz, N. L., Fredrickson, E. D., McGuire, K. M., Nazikian, R., Park, H. K., Schivell, J., Taylor, G., Bitter, M., Budny, R., Cohen, S. A., Kilpatrick, S. J., LeBlanc, B., Manos, D. M., Meade, D., Paul, S. F., Scott, S. D., Stratton, B. C., Synakowski, E. J., Towner, H. H., Wieland, R. M., Arunasalam, V., Bateman, G., Bell, M. G., Bell, R., Boivin, R., Cavallo, A., Cheng, C. Z., Chu, T. K., Co   +31 more
openaire   +2 more sources

Signature of heavy Majorana neutrinos at a linear collider: Enhanced charged Higgs pair production

, 2007
A charged Higgs pair can be produced at an ee collider through a t-channel exchange of a heavy neutrino (N) via e^+ e^- -> H^+ H^- and, if N is a Majorana particle, also via the lepton number violating (LNV) like-sign reaction e^\pm e^\pm \to H^\pm H^\pm.
A. Ali, Amarjit Soni, David Atwood, F. del Aguila, J. Gluza, Shaouly Bar-Shalom   +5 more
core   +1 more source

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source