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Olfactory Tuft Cells Are Critical to Basal Inflammation, Innate Immune Response to Viral Infection, and Modulation of Quiescent Stem Cell Activation, Proliferation and Differentiation. [PDF]
Cell ProlifOlfactory tuft cells communicate with other mucosal cells in maintaining olfactory epithelial immunity and sensory function. Disruption of tuft cell signalling pathways causes a skewed immune response, leading to heightened inflammation and increased activation of the quiescent stem cells, which are further exacerbated by viral infection.Zhang SS, Wang H, Yang YS, Li YH, Yu D, Yao Y, Zhou R, Huang L. +7 moreeuropepmc +2 more sourcesAge-specific vaccine effectiveness of seasonal 2010/2011 and pandemic influenza A(H1N1) 2009 vaccines in preventing influenza in the United Kingdom [PDF]
, 2013 An analysis was undertaken to measure age-specific vaccine effectiveness (VE) of 2010/11 trivalent seasonal influenza vaccine (TIV) and monovalent 2009 pandemic influenza vaccine (PIV) administered in 2009/2010.Ellis, J., Fleming, D.M., Pebody, R.G., Andrews, Nick, Zambon, Maria, McMenamin, J., Moore, C., Hearns, C., Carman, W., Cottrell, S., Smyth, B., Durnall, H., Watson, J.M., Robertson, Chris, Sebastian-Pillai, P., Thomas, D.R., Andrews, N., Fleming, D. M., Robertson, C., Thomas, D. R., Kearns, C., Watson, J. M., Pebody, R. G., Zambon, M. +23 morecore +4 more sourcesInfluenza A (H1N1) 2009 : impact on Frankfurt in due consideration of health care and public health [PDF]
, 2010 Background: In April 2009 a novel influenza A H1N1/2009 virus was identified in Mexico and in the United States which quickly spread around the world.Harald Bias, David A Groneberg, René Gottschalk, Bias, Harald, Gottschalk, René, Rabenau, Holger, Groneberg, Jan David Alexander, Groneberg David A, Holger F Rabenau, Sabine Wicker, Gottschalk René, Rabenau Holger F, Wicker, Sabine, Bias Harald, Wicker Sabine +14 morecore +1 more sourceReplication, Pathogenesis and Transmission of Pandemic (H1N1) 2009 Virus in Non-Immune Pigs [PDF]
, 2010 The declaration of the human influenza A pandemic (H1N1) 2009 (H1N1/09) raised important questions, including origin and host range [1,2]. Two of the three pandemics in the last century resulted in the spread of virus to pigs (H1N1, 1918; H3N2, 1968 ...Essen, Stephen C., Bhudipa Choudhury, Jill Banks, Reeth, Kristien Van, Nunez, Alejandor, Garcon, Fanny, Nunez, A., Gardner, Rebecca, Van Reeth, Kristien, Bethany Nash, Brookes, Sharon M., Peter M H Heegaard, Alejandro Núñez, Foni, Emanuela, Irvine, Richard M., Foni, E., Jaime Maldonado Garcia, Stéphane Quéguiner, Emanuela Foni, Essen, Stephen C, Chiapponi, C., Larsen, Lars, Ian H Brown, Queguiner, S., Sharon M Brookes, Bublot, Michel, Slomka, M.J., Chiapponi, Chiara, Clifford, Derek, Garcia, Jaime M, Willie Loeffen, Choudhury, B., Nunez, Alejandro, Choudhury, Bhudipa, Kuntz-Simon, Gaélle, Essen, S.C., Matrosovich, M., Heegaard, P.M.H., Michel Bublot, Gardner, R., Matrosovich, Mikhail, Brookes, Sharon M, Brown, Ian H., Heegaard, Peter M. H., Fanny Garcon, Slomka, Marek J, Loeffen, Willie, Larsen, Lars Erik, Garcon, F., Loeffen, W.L.A., Heegaard, Peter MH, Irvine, R.M., Reeth, K., Banks, J., Chiara Chiapponi, Irvine, Richard M, Queguiner, Stéphane, Lars Larsen, Amanda Hanna, Kuntz-Simon, G., Brown, I.H., Banks, Jill, Richard M Irvine, Slomka, Marek J., Nash, Bethany, Garcia, Jaime Maldonado, Marek J Slomka, Nash, B., Mikhail Matrosovich, Hanna, Amanda, Stephen C Essen, Gaëlle Kuntz-Simon, Kristien Van Reeth, Derek Clifford, Rebecca Gardner, Hanna, A., Garcia, J.M., Brookes, S.M., Clifford, D., Brown, Ian H, Bublot, M., Heegaard, Peter M.H., Larsen, L., Van Reeth Kristien, Slomka Marek J., Kuntz-Simon Gaëlle, Hanna Amanda, Choudhury Bhudipa, Quéguiner Stéphane, Matrosovich Mikhail, Núñez Alejandro, Clifford Derek, Garcon Fanny, Essen Stephen C., Irvine Richard M., Bublot Michel, Gardner Rebecca, Heegaard Peter M. H., Larsen Lars, Garcia Jaime Maldonado, Brown Ian H., Nash Bethany, Chiapponi Chiara, Loeffen Willie, Brookes Sharon M., Banks Jill, Foni Emanuela +106 morecore +2 more sourcesEstimation of outbreak severity and transmissibility : influenza A(H1N1)pdm09 in households [PDF]
, 2012 When an outbreak of a novel pathogen occurs, some of the most pressing questions from a public-health point of view relate to its transmissibility, and the probabilities of different clinical outcomes following infection, to allow an informed response ...Inglis, N., Ross, Joshua V, Smith Gillian, Suleman, Shakeel, Smith, Gillian, Inglis Nadia, Edeghere Obaghe, Keeling, M., Wilson, F., Wilson Fay, Gillian Smith, Keeling, Matt J, Ross, J., Wilson, Fay, Inglis, Nadia, Fay Wilson, Olowokure, Babatunde, House Thomas, House, Thomas A., Obaghe Edeghere, Olowokure Babatunde, Smith, G., Ross Joshua V, Joshua V Ross, Ross, Joshua V., Babatunde Olowokure, Shakeel Suleman, Suleman Shakeel, Keeling Matt J, Edeghere, Obaghe, Keeling, Matthew James, Edeghere, O., House, Thomas; id_orcid, Suleman, S., House, T., Thomas House, Nadia Inglis, Olowokure, B., Matt J Keeling +38 morecore +2 more sourcesPost-pandemic seroprevalence of pandemic influenza A (H1N1) 2009 infection (swine flu) among children <18 years in Germany. [PDF]
, 2011 We determined antibodies to the pandemic influenza A (H1N1) 2009 virus in children to assess: the incidence of (H1N1) 2009 infections in the 2009/2010 season in Germany, the proportion of subclinical infections and to compare titers in vaccinated and ...Thomas Mertens, Andrea Streng, Niehues Tim, Stephan Wirth, Rüdiger von Kries, Hampl, Walter, Michel, Detlef, Shai, Sonu, Falkenhorst, Gerhard, Kaiser, Petra, Weiss Susanne, von Kries, Rüdiger, Walter Hampl, Schroten Horst, König, Carl-Heinz Wirsing von, Tenenbaum, Tobias, Niehues, Tim, Peters, Jochen, Carl Heinz Wirsing von König, Tobias Tenenbaum, Susanne Weiss, Petra Kaiser, Wirsing von Koenig, Carl Heinz, Hans-Iko Huppertz, Ellen Kuscher, Mertens Thomas, Hermann Girschick, Weiss, Susanne, Wirsing von König, Carl-Heinz, Tim Niehues, Huppertz, Hans-Iko, Simon Rückinger, Streng, Andrea, Kries, Rüdiger von, Kaiser Petra, Horst Schroten, Sonu Shai, Falkenhorst Gerhard, Wirsing von König Carl Heinz, Axel Sauerbrey, Liese, Johannes, Johannes Liese, Mertens, Thomas, Rückinger Simon, Hampl Walter, Schroten, Horst, Sauerbrey, Axel, Gerhard Falkenhorst, Shai Sonu, Huppertz Hans-Iko, von Kries Rüdiger, Rückinger, Simon, Tenenbaum Tobias, Jochen Peters, Wirth Stephan, Liese Johannes, Girschick, Hermann, Peters Jochen, Michel Detlef, Streng Andrea, Sauerbrey Axel, Wirth, Stephan, Kuscher Ellen, Detlef Michel, Girschick Hermann, Kuscher, Ellen +65 morecore +2 more sourcesThe comparative clinical course of pregnant and non-pregnant women hospitalised with influenza A(H1N1)pdm09 infection [PDF]
, 2012 Introduction: The Influenza Clinical Information Network (FLU-CIN) was established to gather detailed clinical and epidemiological information about patients with laboratory confirmed A(H1N1)pdm09 infection in UK hospitals.Read, R. C., Openshaw, Peter J.M., Semple, Malcolm G., Lim Wei Shen, Semple, MG, Bannister Barbara, Taylor, B. L., Taylor Bruce L., Puja R. Myles (145227), Read Robert C., Semple, M. G., Wei Shen Lim (145243), Net, I. C. I., Semple Malcolm G., Karl G. Nicholson (145257), Myles Puja R., Bannister, Barbara, Brett, S. J., Nguyen-Van-Tam, Jonathan S., Stephen J Brett, Jonathan S. Nguyen-Van-Tam (145263), Peter J M Openshaw, Myles, PR, Barbara Bannister, Jonathan S Nguyen-Van-Tam, James McMenamin (145252), Brett, SJ, Puja R Myles, James McMenamin, Lim, W. S., Brett Stephen J., Nguyen-Van-Tam, JS, Enstone Joanne E., Karl G Nicholson, Wei Shen Lim, Enstone, Joanne E., Nicholson, Karl G., Openshaw Peter J. M., Dolan, G. P., Enstone, J. E., Robert C Read, Stephen J. Brett (145230), Brett, Stephen J., Lim, Wei Shen, McMenamin, J., Bruce L Taylor, Read, Robert C., Read, RC, Peter J. M. Openshaw (145235), McMenamin, J, Myles, Puja R., Joanne E Enstone, Dolan, Gayle P., Enstone, JE, Myles, P. R., Nicholson, KG, Gayle P. Dolan (145225), Robert C. Read (145234), Malcolm G Semple, Malcolm G. Semple (80199), Lim, WS, Taylor, BL, Nicholson, K. G., Nguyen-Van-Tam Jonathan S., McMenamin, James, Bruce L. Taylor (145248), Dolan Gayle P., Barbara Bannister (145260), Nguyen-Van-Tam, J. S., Influenza Clinical Information Network (FLU-CIN), Taylor, Bruce L., Dolan, GP, Bannister, B., Nicholson Karl G., Openshaw, P. J. M., Gayle P Dolan, McMenamin James, Openshaw, PJM, Joanne E. Enstone (145232), Bannister, B +79 morecore +1 more sourceEstimating reassortment rates in co-circulating Eurasian swine influenza viruses [PDF]
, 2012 Swine have often been considered as a mixing vessel for different influenza strains. In order to assess their role in more detail, we undertook a retrospective sequencing study to detect and characterize the reassortants present in European swine and to ...Pybus, OG, McCauley, J. W., Brown, I. H., Kellam, P., Lycett, S., Baillie, G., Baillie, G, Coulter, E, Brown, IH, Lycett, S. J., Lycett, SJ, Coulter, E., McCauley, JW, Leigh Brown, A., Wood, J. L. N., Pybus, Oliver G., Bhatt, S., Kellam, P, N Wood, J., ?, ?, Wood, JLN, Bhatt, S, Brown, AJ Leigh, Brown, A. J. Leigh, Pybus, O. G., Brown, I., McCauley, J. +26 morecore +1 more sourceA randomised, partially observer-blind, multicentre, head-to-head comparison of a two-dose regimen of Baxter and GlaxoSmithKline H1N1 pandemic vaccines, administered 21 days apart
Health Technology Assessment, 2010 Objectives: To evaluate the immunogenicity of a two-dose schedule of Baxter cell-cultured, non-adjuvanted, whole-virion H1N1 vaccine, and GlaxoSmithKline AS03A-adjuvanted split-virion H1N1 vaccine with respect to the EU Committee for Medicinal Products ...KG Nicholson, KR Abrams, S Batham, TW Clark, K Hoschler, WS Lim, M Medina, JS Nguyen-Van-Tam, RC Read, FC Warren, M Zambon +10 moredoaj +1 more source