Results 61 to 70 of about 33,674 (168)

Toward Predicting Pandemic Potential: A Comparative Analysis of Virus‐Host Interactions Between Diverse Influenza A Viruses and the Human Innate Immune System

PROTEOMICS, EarlyView.
ABSTRACT Zoonotic infections caused by influenza A viruses (IAVs) of animal origin are a major public health concern, as they may represent the initial step toward the emergence of a pandemic strain. The host range of IAVs is shaped by species‐specific virus‐host interactions, and several host barriers have been identified that restrict the adaptation ...
Antoine Gerodez, Melanie Dos Santos, Mikaël Attia, Killian De Geest, Ibrahim Hamid, Rodrigue Tesse, Ilham Fdillate, Marc Boschmans, Steven Van Borm, Mieke Steensels, Benedicte Lambrecht, Lionel Tafforeau, Caroline Demeret, Cyril Barbezange   +13 more
wiley   +1 more source

Clinico-Epidemiological Profile and Study of Influenza and Their Subtypes Among Suspected Influenza Patients in a Tertiary Care Teaching Hospital of Vadodara

GAIMS Journal of Medical Sciences
Background: Influenza viruses cause significant respiratory illness, with seasonal epidemics and occasional pandemics influenced by antigenic variation. Monitoring local prevalence and subtype distribution is vital for guiding public health responses.
Gulshan Chaudhary, Jigna Karia, Yash Khandelwal   +2 more
doaj   +1 more source

Identification of a highly conserved H1 subtype-specific epitope with diagnostic potential in the hemagglutinin protein of influenza A virus. [PDF]

PLoS ONE, 2011
Subtype specificity of influenza A virus (IAV) is determined by its two surface glycoproteins, hemagglutinin (HA) and neuraminidase (NA). For HA, 16 distinct subtypes (H1-H16) exist, while nine exist for NA.
Rongmao Zhao, Shujuan Cui, Li Guo, Chao Wu, Richard Gonzalez, Gláucia Paranhos-Baccalà, Guy Vernet, Jianwei Wang, Tao Hung   +8 more
doaj   +1 more source

Modeling the lung‒brain axis in critical illness: Multifactorial crosstalk through organoids and organ‐on‐a‐chip system

VIEW, EarlyView.
Patients in intensive care units often experience lung injuries, complicated by brain problems. Advanced laboratory tools, organoids, and organs‐on‐chips facilitated the study of multiorgan interactions, help us understand the communication between the lungs and brain.
Wanyi Zhang, Ting Wang, Mengying Yao, Longxiang Su, Lixin Xie, Pan Pan   +5 more
wiley   +1 more source

Phylogenetic Analysis of HA and NA Genes of Swine Influenza Viruses in Serbia in 2016-2018

Acta Veterinaria, 2020
Pigs are very important for the epidemiology of influenza A viruses, being commonly infected with the lineages of most adapted H1N1, H3N2, H1N2 swine subtypes.
Maksimović Zorić Jelena, Milićević Vesna, Stevančević Ognjen, Chiapponi Chiara, Potkonjak Aleksandar, Stojanac Nenad, Kureljušić Branislav, Veljović Ljubiša, Radosavljević Vladimir, Savić Božidar   +9 more
doaj   +1 more source

Immunogenicity of a Multi‐Epitope Influenza Composite Peptide Vaccine Targeting Human, Swine, and Avian Viruses: Advancing Pandemic Preparedness

Influenza and Other Respiratory Viruses, Volume 20, Issue 7, July 2026.
ABSTRACT Background The emergence of novel reassortant influenza A virus strains and zoonotic transmission to the human population is a critical factor in the development of a global pandemic, as exemplified by the 2009 swine flu pandemic and the ongoing threat of an H5N1 avian flu pandemic.
Nimisha Rikhi, Clara J. Sei, Kellie A. Fraser, Kevin Muema, Aba Assiaw‐Dufu, Richard F. Schuman, Gerald W. Fischer   +6 more
wiley   +1 more source

Hypertransaminasemia Is a Marker of Severity in Children Hospitalized for Influenza

Influenza and Other Respiratory Viruses, Volume 20, Issue 7, July 2026.
ABSTRACT Purpose Elevated transaminases have been associated with increased severity in adult influenza cases, but data in the pediatric population are limited. This study aims to evaluate the prevalence, clinical characteristics and prognostic value of elevated transaminases in children hospitalized for influenza.
Marco Poeta, Cristina Moracas, Elisabetta Venturini, Sofia Sgubbi, Maria Sole Valentino, Laura Folgori, Laura Petrarca, Claudio Cafagno, Marco Maglione, Anna Cascone, Claudia Colomba, Alice Romero, Fabio Midulla, Giuseppe Indolfi, Vania Giacomet, Amelia Licari, Luisa Galli, Alfredo Guarino   +17 more
wiley   +1 more source

C4b Binding Protein Acts as an Innate Immune Effector Against Influenza A Virus

Frontiers in Immunology, 2021
C4b Binding Protein (C4BP) is a major fluid phase inhibitor of the classical and lectin pathways of the complement system. Complement inhibition is achieved by binding to and restricting the role of activated complement component C4b. C4BP functions as a
Praveen M. Varghese, Praveen M. Varghese, Valarmathy Murugaiah, Nazar Beirag, Nigel Temperton, Haseeb A. Khan, Salman H. Alrokayan, Mohammed N. Al-Ahdal, Beatrice Nal, Futwan A. Al-Mohanna, Robert B. Sim, Uday Kishore   +11 more
doaj   +1 more source

A Sequence‐Based Update on Amino Acid Substitutions in Influenza Polymerase Acidic Protein in Europe That Alter Baloxavir Susceptibility From 2009 to 2025

Influenza and Other Respiratory Viruses, Volume 20, Issue 7, July 2026.
ABSTRACT Background Influenza causes 650,000 deaths, 3–5 million hospitalizations, and 1 billion cases worldwide each year. There is a limited repertoire of antivirals available to tackle this burden, highlighting the risk of developing resistance to current drugs.
Alejandro Martín‐Toribio, Inés Inchausti‐Moya, Marina Toquero‐Asensio, Sonia García‐Díaz, Javier Sanchez‐Martinez, Carla Rodriguez‐Crespo, Silvia Galindo‐Carretero, Raquel Iglesia‐Aparicio, Celia Lopez‐Gonzalo, Ana Antón‐Contreras, Silvia Rojo‐Rello, Marta Dominguez‐Gil, Marta Hernández, Jose M. Eiros, Estanislao Nistal‐Villan, Iván Sanz‐Muñoz   +15 more
wiley   +1 more source

A single base-pair change in 2009 H1N1 hemagglutinin increases human receptor affinity and leads to efficient airborne viral transmission in ferrets.

PLoS ONE, 2011
The 2009 H1N1 influenza A virus continues to circulate among the human population as the predominant H1N1 subtype. Epidemiological studies and airborne transmission studies using the ferret model have shown that the transmission efficiency of 2009 H1N1 ...
Akila Jayaraman, Claudia Pappas, Rahul Raman, Jessica A Belser, Karthik Viswanathan, Zachary Shriver, Terrence M Tumpey, Ram Sasisekharan   +7 more
doaj   +1 more source