Results 71 to 80 of about 44,653 (211)

MTH1 deficiency selectively increases non-cytotoxic oxidative DNA damage in lung cancer cells: more bad news than good?

BMC Cancer, 2018
Background Targeted therapies are based on exploiting cancer-cell-specific genetic features or phenotypic traits to selectively kill cancer cells while leaving normal cells unaffected. Oxidative stress is a cancer hallmark phenotype.
Hussein H. K. Abbas, Kheloud M. H. Alhamoudi, Mark D. Evans, George D. D. Jones, Steven S. Foster   +4 more
doaj   +1 more source

Success by Design: Senior Leadership Perspectives on Optimising the Role of Clinical Nurse Specialists

Journal of Advanced Nursing, EarlyView.
ABSTRACT Aims To report on the unique perspectives of senior nursing leaders on the value proposition of the Clinical Nurse Specialist (CNS) role, their organisational experience and the barriers and facilitators to optimise and promote the long‐term sustainability.
Sandra B. Lauck, Leah K. Lambert, Natasha Prodan‐Bhalla, Farinaz Havaei, Denise Bryant‐Lukosius, Jagbir Kaur, Kevin Hare, Sherri Lynn Kensall, Becky Palmer, Sally Thorne   +9 more
wiley   +1 more source

Extracellular vesicles secreted by hypoxia pre-challenged mesenchymal stem cells promote non-small cell lung cancer cell growth and mobility as well as macrophage M2 polarization via miR-21-5p delivery

Journal of Experimental & Clinical Cancer Research, 2019
Objective To investigate the lung cancer-promoting mechanism of mesenchymal stem cell-secreted extracellular vesicles (MSC-EV). Methods EV were isolated from culture media of human bone marrow-derived MSCs that were pre-challenged with or without hypoxia
Weihua Ren, Jianfeng Hou, Chenguang Yang, Hanjun Wang, Shuangting Wu, Yabin Wu, Xingpeng Zhao, Chao Lu   +7 more
doaj   +1 more source

The Four Bars Problem

, 2016
A four-bar linkage is a mechanism consisting of four rigid bars which are joined by their endpoints in a polygonal chain and which can rotate freely at the joints (or vertices).
Jungers, Raphaël, Langerman, Stefan, Mauroy, Alexandre, Taslakian, Perouz   +3 more
core   +1 more source

Peripheral Inflammation and Sleep Loss Induce Coordinated Motivational Changes: An Experimental Two‐Hit Stress Model

Journal of Sleep Research, EarlyView.
ABSTRACT Sleep loss and low‐grade inflammation are common stressors that affect behaviour and recovery needs. To examine their separate and combined effects on motivation for everyday behaviours, we developed a two‐hit experimental model. Participants (N = 56, 31 women) completed three experimental visits: sleep saturation (two nights, 9 h in bed/night)
John Axelsson, Mats Lekander, Camilla I. Svensson, Nils Simon, Alexandra Kuliszkiewicz, Julie Lasselin, Leonie J. T. Balter   +6 more
wiley   +1 more source

Radiation-induced matrix metalloproteinases limit natural killer cell-mediated anticancer immunity in NCI-H23 lung cancer cells

Molecular Medicine Reports, 2014
Radiotherapy has been used to treat cancer for >100 years and is required by numerous patients with cancer. Ionizing radiation effectively inhibits the growth of cancer cells by inducing cell death and increasing anticancer immunity, through the induction of natural killer group 2 member D ligands (NKG2DLs); however, adverse effects have also been ...
Woong, Heo, Young Shin, Lee, Cheol Hun, Son, Kwangmo, Yang, You Soo, Park, Jaeho, Bae   +5 more
openaire   +3 more sources

Pediatric transfusion camp: Developing, piloting and evaluation of a Canadian national pediatric transfusion medicine curriculum

Transfusion, EarlyView.
Abstract Background Standardized post‐graduate education in pediatric transfusion medicine remains limited. The objective of this study was to adapt an adult transfusion education program, Transfusion Camp, to include pediatric content and assess knowledge improvement in pediatric subspecialty trainees.
Ines Zuna, Valérie Arsenault, Kimmo Murto, Suzanne Beno, MacGregor Steele, Jennifer Young, Sarah Leir, Angela Punnett, Cheryl Peters, Lucille Barcat, Yulia Lin, Casey Kapitany, Sophie Chargé, Teresa Skelton, Lani Lieberman   +14 more
wiley   +1 more source

Evolution of Crematogaster sordidula (Hymenoptera, Formicidae) Ants in the Mediterranean Region During Plio‐Pleistocene Climatic Changes

Zoologica Scripta, EarlyView.
ABSTRACT Understanding insect responses to global climate change involves identifying strategies used during past climate oscillations. Phylogeography offers a powerful framework to unravel how historical climatic and geological events have shaped the spatial genetic patterns of species, providing critical insights into evolutionary processes, whereas ...
Jody H. Voges, Sebastian Salata, Lech Borowiec, Jelena Bujan, Christos Georgiadis, Celal Karaman, Kadri Kiran, Albena Lapeva‐Gjonova, Claude Lebas, Mattia Menchetti, Enrico Schifani, Ahmed Taheri, Bonnie B. Blaimer   +12 more
wiley   +1 more source

Economic Impacts of Pink Hibiscus Mealybug in Florida and the United States [PDF]

Replaced with revised version of paper 12/15/05.Invasive Species, Political Economy, Tariffs, Bargaining, Interest Groups, International Relations/Trade, H23, Q17, Q58,
Ranjan, Ram
core   +1 more source

Equivalences of Zt×Z22-cocyclic Hadamard matrices [PDF]

, 2015
One of the most promising structural approaches to resolving the Hadamard Conjecture uses the family of cocyclic matrices over Zt × Z2 2. Two types of equivalence relations for classifying cocyclic matrices over Zt × Z2 2 have been found.
Gudiel Rodríguez, Félix, Güemes Alzaga, María Belén, Horadam, K.J., Rao, A., Álvarez Solano, Víctor   +4 more
core